Results 11 to 20 of about 9,721 (212)

Promoter Sequence of Shiga Toxin 2 (Stx2) Is Recognized In Vivo , Leading to Production of Biologically Active Stx2 [PDF]

mBio, 2013
ABSTRACT Shiga toxins (Stx) are the main agent responsible for the development of hemolytic-uremic syndrome (HUS), the most severe and life-threatening systemic complication of infection with enterohemorrhagic Escherichia coli (EHEC) strains.
Leticia V. Bentancor, Maria P. Mejías, Alípio Pinto, Marcos F. Bilen, Roberto Meiss, Maria C. Rodriguez-Galán, Natalia Baez, Luciano P. Pedrotti, Jorge Goldstein, Pablo D. Ghiringhelli, Marina S. Palermo   +10 more
openaire   +5 more sources

Characterization of Stx2 Tubular Response in a Rat Experimental Model of Hemolytic Uremic Syndrome [PDF]

American Journal of Nephrology, 2010
<i>Background/Aims:</i> In Argentina, hemolytic uremic syndrome (HUS) constitutes the most frequent cause of acute renal failure in children. The aim of our study was to analyze the early tubular response under the effect of Shiga toxin type 2 (Stx2) in a rat experimental model of HUS.
Ochoa, Federico Claudio, Lago, N. R., Gerhardt, Elizabeth, Ibarra, Cristina Adriana, Zotta, E.   +4 more
openaire   +4 more sources

Biodistribution and elimination kinetics of systemic Stx2 by the Stx2A and Stx2B subunit-specific human monoclonal antibodies in mice

BMC Immunology, 2012
Background Hemolytic uremic syndrome (HUS) leading to acute kidney failure, is a condition linked to the production of primarily Shiga toxin 2 (Stx2) by some E. coli serotypes.
Sheoran Abhineet, Jeong Kwang-il, Mukherjee Jean, Wiffin Anthony, Singh Pradeep, Tzipori Saul   +5 more
doaj   +2 more sources

Mouse Model of Hemolytic-Uremic Syndrome Caused by Endotoxin-Free Shiga Toxin 2 (Stx2) and Protection from Lethal Outcome by Anti-Stx2 Antibody [PDF]

Infection and Immunity, 2008
ABSTRACTHemolytic-uremic syndrome (HUS) results from infection by Shiga toxin (Stx)-producingEscherichia coliand is the most common cause of acute renal failure in children. We have developed a mouse model of HUS by administering endotoxin-free Stx2 in multiple doses over 7 to 8 days.
Sauter, Kristin A D, Melton-Celsa, Angela R, Larkin, Kay, Troxell, Megan L, O'Brien, Alison D, Magun, Bruce E   +5 more
openaire   +5 more sources

Regulatory elements of stx2 gene and the expression level of Shiga-like toxin 2 in Escherichia coli O157:H7

Journal of Microbiology, Immunology and Infection, 2018
Background/Purpose: Shiga-like toxin (Stx) is an important factor in the pathogenesis of Escherichia coli O157:H7 infection and is responsible for some severe complications. Stx2 is usually associated with hemolytic uremic syndrome in humans.
I Wayan Suardana, Komang Januartha Putra Pinatih, Dyah Ayu Widiasih, Wayan Tunas Artama, Widya Asmara, Budi Setiadi Daryono   +5 more
doaj   +3 more sources

Antimicrobials resistance patterns and the presence of stx1, stx2 and eae in Escherichia coli [PDF]

Revista Brasileira de Saúde e Produção Animal, 2015
The objectives of this study were to investigate whether antimicrobial resistance (AMR) or the presence of resistance genes was associated with the occurrence of the virulence genes, stx1, stx2 andeae. Three virulence genes and 11 AMR phenotypes were examined using polymerase chain reaction (PCR) and antimicrobial susceptibility tests. From 800 samples
AssumpÇÃo, Gustavo Lacerda Homem, Cardozo, Marita Vendovelli, Beraldo, Lívia Gerbase, Maluta, Renato Pariz, Silva, Joviany Talita, Avila, Fernando Antonio De, Mcintosh, Douglas, Rigobelo, Everlon Cid   +7 more
openaire   +7 more sources

Role of Shiga Toxins in Cytotoxicity and Immunomodulatory Effects of Escherichia coli O157:H7 during Host-Bacterial Interactions in vitro

Toxins, 2020
Enterohemorrhagic Escherichia coli (EHEC) strains are food-borne pathogens that can cause different clinical conditions. Shiga toxin 2a and/or 2c (Stx2)-producing E. coli O157:H7 is the serotype most frequently associated with severe human disease.
Andrea Cecilia Bruballa, Carolina Maiumi Shiromizu, Alan Mauro Bernal, Gonzalo Ezequiel Pineda, Florencia Sabbione, Analia Silvina Trevani, Leticia Verónica Bentancor, María Victoria Ramos, Romina Jimena Fernández-Brando, Manuel Javier Muñoz, Marina Sandra Palermo   +10 more
doaj   +1 more source

Microbial interaction-driven community differences as revealed by network analysis

Computational and Structural Biotechnology Journal, 2021
Diversity and compositional analysis are the most common approaches in deciphering microbial community differences. However, these approaches neglect microbial structural differences driven by microbial interactions.
Zhe Pan, Yanhong Chen, Mi Zhou, Tim A. McAllister, Le Luo Guan   +4 more
doaj   +1 more source

Serotypes and Stx2 subtyping of Shiga toxin producing Escherichia coli isolates from cattle carcasses and feces

Revista Mexicana de Ciencias Pecuarias, 2020
Shiga toxin E. coli (STEC) is an important pathogen responsible for foodborne illness, this have been related with epidemic outbreaks in the past, mainly because of consumption of bovine meat.
Nydia Edith Reyes-Rodriguez, Jeannette Barba-León, Armando Navarro-Ocaña, Vicente Vega-Sanchez, Fabian Ricardo Gómez De Anda, Juan Martin Talavera-Gonzalez, Martin Talavera-Rojas   +6 more
doaj   +1 more source

STX2 Promotes Trophoblast Growth, Migration, and Invasion Through Activation of the PI3K-AKT Pathway in Preeclampsia

Frontiers in Cell and Developmental Biology, 2021
ObjectivesAbnormal trophoblast behaviors during pregnancy contribute to the development of preeclampsia (PE). Syntaxin2 (STX2) has been shown to be a crucial epithelial mediator in numerous diseases.
Yan Li, Xian-li Sun, Chun-ling Ma, Chao Li, Ying Zhan, Wen-ting Li, Can Li, Yi-hao Wang   +7 more
doaj   +1 more source