Results 21 to 30 of about 9,721 (212)

Antibody Screening and Binding Prediction Analysis Targeting Stx2. [PDF]

Antibodies (Basel)
Background: Shiga toxin (Stx), produced by enterohemorrhagic Escherichia coli (EHEC), is a highly potent exotoxin responsible for severe complications such as hemolytic uremic syndrome (HUS). Among its isoforms, Stx2 exhibits stronger cytotoxicity and poses greater clinical risk, yet no effective therapy currently exists.
Wu J, Liu C, Peng F, Yu Z, Qiao C, Yang G, Luo H, Sun K, Ning Z, Wang J, Wen Y, Yu J.   +11 more
europepmc   +3 more sources

The effect of two ribonucleases on the production of Shiga toxin and stx-bearing bacteriophages in Enterohaemorrhagic Escherichia coli

Scientific Reports, 2021
Enterohaemorrhagic Escherichia coli (EHEC) comprise a group of intestinal pathogens responsible for a range of illnesses, including kidney failure and neurological compromise.
Patricia B. Lodato
doaj   +1 more source

Neutralizing antibodies to Shiga toxin type 2 (Stx2) reduce colonization of mice by Stx2-expressing Escherichia coli O157:H7 [PDF]

Vaccine, 2010
Previously, we showed that the Shiga toxin type 2 (Stx2)-expressing Escherichia coli O157:H7 strain 86-24 colonized mice better than did its isogenic stx(2) negative mutant. Here, we confirmed that finding by demonstrating that Stx2 given orally to mice increased the levels of the 86-24 stx(2) mutant shed in feces.
Krystle L, Mohawk, Angela R, Melton-Celsa, Cory M, Robinson, Alison D, O'Brien   +3 more
openaire   +2 more sources

Stx2-Specific Human Monoclonal Antibodies Protect Mice against Lethal Infection with Escherichia coli Expressing Stx2 Variants [PDF]

Infection and Immunity, 2003
ABSTRACT Shiga toxin-producing Escherichia coli (STEC) strains are responsible for causing hemolytic-uremic syndrome (HUS), and systemic administration of Shiga toxin (Stx)-specific human monoclonal antibodies (HuMAbs) is considered a promising approach for prevention or treatment of the disease in ...
Abhineet S, Sheoran, Susan, Chapman, Pradeep, Singh, Arthur, Donohue-Rolfe, Saul, Tzipori   +4 more
openaire   +2 more sources

A comparison of Shiga-toxin 2 bacteriophage from classical enterohemorrhagic Escherichia coli serotypes and the German E. coli O104:H4 outbreak strain. [PDF]

PLoS ONE, 2012
Escherichia coli O104:H4 was associated with a severe foodborne disease outbreak originating in Germany in May 2011. More than 4000 illnesses and 50 deaths were reported. The outbreak strain was a typical enteroaggregative E. coli (EAEC) that acquired an
Chad R Laing, Yongxiang Zhang, Matthew W Gilmour, Vanessa Allen, Roger Johnson, James E Thomas, Victor P J Gannon   +6 more
doaj   +1 more source

Detection of stx2 from Shiga toxin-producing Escherichia coli (STEC) by a Surface Enhanced Raman Spectroscopy (SERS) sensor using recycled silicon chips [PDF]

, 2022
In this research, a selective, cost-efficient, highly sensitive Ag nanostructure Surface Enhanced Raman Spectroscopy (SERS) sensor was developed as a methodological approach to rapidly detect a targeted-ss-DNA (stx2) in STEC (Shiga toxin-producing ...
Catherine , M. Burgess, Pierre, Lovera, Alan , O’Riordan, Luiza Adela , Wasiewska, Geraldine , Duffy, Yuqing, Yang, Pierre Lovera, Luiza Adela Wasiewska, Yuqing Yang, Geraldine Duffy, Catherine M. Burgess, Alan O’Riordan   +11 more
core   +1 more source

Protection of Mice against Shiga Toxin 2 (Stx2)-Associated Damage by Maternal Immunization with a Brucella Lumazine Synthase-Stx2 B Subunit Chimera [PDF]

Infection and Immunity, 2014
ABSTRACTHemolytic-uremic syndrome (HUS) is defined as the triad of anemia, thrombocytopenia, and acute kidney injury. Enterohemorrhagic Shiga toxin (Stx)-producingEscherichia coli(EHEC), which causes a prodromal hemorrhagic enteritis, remains the most common etiology of the typical or epidemic form of HUS.
Mejias, Maria Pilar, Cabrera, Gabriel, Fernández Brando, Romina Jimena, Baschkier, Ariela, Ghersi, Giselle, Abrey Recalde, Maria Jimena, Miliwebsky, Elyzabeth, Meiss, Roberto, Goldbaum, Fernando Alberto, Zylberman, Vanesa, Rivas, Marta, Palermo, Marina Sandra   +11 more
openaire   +3 more sources

Characterization of verotoxigenic E.coli and enteropathogenic E.coli isolated from infants with diarrhea in combination with antimicrobial resistance pattern in Minia, Egypt [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences, 2020
Diarrheal disease is considered a significant health problem, principally in developing countries as it is one of the leading causes of morbidity and mortality especially in infants. Studies found that STES and EPEC strains are among the most predominant
Shimaa Abd El Gany, Gamal Mahmoud Gad, Suzan Mousa, Reham Ibrahem   +3 more
doaj   +1 more source

Stx2 Subtyping of Shiga Toxin-Producing Escherichia coli Isolated from Cattle in France: Detection of a New Stx2 Subtype and Correlation with Additional Virulence Factors [PDF]

Journal of Clinical Microbiology, 2001
ABSTRACT At least 11 Stx2 variants produced by Shiga toxin-producing Escherichia coli (STEC) isolated from patients and animals have been described. The Stx2 subtyping of STEC isolated from healthy cows positive for stx 2
Bertin, Yolande, Boukhors, K., Pradel, N., Livrelli, N., Martin, C.   +4 more
openaire   +6 more sources

Scalable Reporter Assays to Analyze the Regulation of stx2 Expression in Shiga Toxin-Producing Enteropathogens [PDF]

Toxins, 2021
Stx2 is the major virulence factor of EHEC and is associated with an increased risk for HUS in infected patients. The conditions influencing its expression in the intestinal tract are largely unknown. For optimal management and treatment of infected patients, the identification of environmental conditions modulating Stx2 levels in the human gut is of ...
Martin B. Koeppel, Jana Glaser, Tobias Baumgartner, Stefanie Spriewald, Roman G. Gerlach, Benedikt von Armansperg, John M. Leong, Bärbel Stecher   +7 more
openaire   +3 more sources