Results 61 to 70 of about 9,721 (212)

Integrated scRNA‐Seq and Spatial Transcriptomics Reveal CHPF and GPC1 as Markers of Cancer‐Associated Fibroblast–Dominant Domains in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Spatial heterogeneity in the colorectal cancer (CRC) tumor microenvironment (TME) is closely related to stromal organization and may influence treatment‐related features. In this study, we integrated single‐cell RNA sequencing and spatial transcriptomic data from CRC tissues to examine cancer‐associated fibroblast (CAF)‐dominant spatial ...
Yuan‐jie Liu, Qian‐wen Ye, Hui Zhang, Ning Yang, Yang Li, Jie‐pin Li   +5 more
wiley   +1 more source

Diversity of Shiga toxin transducing phages in Escherichia coli O145:H28 and the different Shiga toxin 2 production levels associated with short- or long-tailed phages

Frontiers in Microbiology
Shiga toxin (Stx)-producing Escherichia coli (STEC) causes serious gastrointestinal illness, including hemorrhagic colitis and hemolytic uremic syndrome. Two types of Stxs (Stx1 and Stx2) are known and both are encoded by bacteriophages (Stx phages), but
Keiji Nakamura, Itsuki Taniguchi, Yasuhiro Gotoh, Junko Isobe, Keiko Kimata, Yukiko Igawa, Tomoko Kitahashi, Yohei Takahashi, Ryohei Nomoto, Kaori Iwabuchi, Yo Morimoto, Sunao Iyoda, Tetsuya Hayashi   +12 more
doaj   +1 more source

The frequency of shiga-like toxin (stx1 and stx2) and EHEC-hlyA in food by multiplex PCR

Romanian Journal of Laboratory Medicine, 2017
Aim: The aim of the present study was to determine the frequency of shiga-like toxin (stx1 and stx2) and drug resistance profiles food-borne Escherichia coli O157:H7 in Hatay province, Turkey.
Onlen Cansu, Duran Nizami, Bayraktar Suphi, Ay Emrah, Ozer Burçin   +4 more
doaj   +1 more source

N-chlorotaurine, a long-lived oxidant produced by human leukocytes, inactivates Shiga toxin of enterohemorrhagic Escherichia coli. [PDF]

PLoS ONE, 2012
N-chlorotaurine (NCT), the main representative of long-lived oxidants produced by granulocytes and monocytes, is known to exert broad-spectrum microbicidal activity.
Christian Eitzinger, Silvia Ehrlenbach, Herbert Lindner, Leopold Kremser, Waldemar Gottardi, Dmitri Debabov, Mark Anderson, Markus Nagl, Dorothea Orth   +8 more
doaj   +1 more source

Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins

Toxins, 2021
Shiga toxin 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol of cells where they target ribosomes. As retrograde trafficking is essential for disease, inhibiting STx1/STx2 trafficking is therapeutically promising.
Andrey S. Selyunin, Karinel Nieves-Merced, Danyang Li, Stanton F. McHardy, Somshuvra Mukhopadhyay   +4 more
doaj   +1 more source

Postharvest Survival of Foodborne Pathogens on Strawberry Surfaces at Different Maturity Levels

Food Safety and Health, Volume 4, Issue 4, Page 949-957, October 2026.
This study highlights the survival of E. coli and L. monocytogenes on strawberries at different maturity stages and storage temperatures. Predictive microbial modeling revealed temperature‐ and ripeness‐dependent survival trends, emphasizing the importance of temperature control and ripeness in developing effective strategies to enhance strawberry ...
Prachi Pahariya, Derek J. Fisher, Abhinav Mishra, Ruplal Choudhary   +3 more
wiley   +1 more source

The neighbor-net visualization of the Stx2 “pan-genome” among E. coli Stx2-bacteriophage and a bacteriophage from Shigella dysenteriae (Table 1).

, 2012
The “pan-genome” consists of 500 bp sequence fragments present in at least 3 bacteriophage sequences at an 85% sequence identity threshold. Labels represent the host-source of the bacteriophage as serotype followed by strain name. Red shading: Stx2-phage
Matthew W. Gilmour (162470), James E. Thomas (162477), Victor P. J. Gannon (162481), Chad R. Laing (162463), Vanessa Allen (162474), Yongxiang Zhang (31421), Roger Johnson (31425)   +6 more
core   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Stx2 Subtypisierung v1

Nach §34 IfSG müssen in Deutschland Personen, die Enterohämorrhagische Escherichia coli (EHEC) ausscheiden, bis zum Ausschluss einer relevanten Infektionsgefahr von Gemeinschaftseinrichtungen ferngehalten werden. Die Wiederzulassung orientiert sich an Empfehlungen des Robert Koch-Instituts (EHEC: Überarbeitung der RKI-Empfehlungen für die ...
Emanuel Heitlinger, Bettina Welter, Nadja Walter, olivia.hollaender not provided, Philipp Zanger   +4 more
openaire   +1 more source

Binding of adenine to Stx2, the protein toxin fromEscherichia coliO157:H7 [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2006
Stx2 is a protein toxin whose catalytic subunit acts as an N-glycosidase to depurinate a specific adenine base from 28S rRNA. In the holotoxin, the catalytic portion, A1, is linked to the rest of the A subunit, A2, and A2 interacts with the pentameric ring formed by the five B subunits.
Marie E, Fraser, Maia M, Cherney, Paola, Marcato, George L, Mulvey, Glen D, Armstrong, Michael N G, James   +5 more
openaire   +2 more sources