Results 51 to 60 of about 3,864,827 (278)

Toxicity of Semaglutide upon sub chronic administration in Rabbits

Toxicological Research
Semaglutide is an anti-obesity and anti-diabetic drug used in long-term weight management and for the treatment of type 2 diabetes. A toxicology study was conducted on a generic synthetic version of Semaglutide Injection (2 mg/3 mL) produced by Biocon Pharma, using New Zealand White Rabbits.
Chandrashekara Vishwanath, Kumar Krishnachari, Gowrav Perdur Adiga, Manohar Madhavdeshmukh, Akanksh Das, Zabiullah Alandur Jamal, Prabhakar Bhoite, Kalaiselvan Ponnusamy, Mohan Krishnappa, Varun Ahuja, Manoj Kumar Pananchukunnath, Anil Kunhihitlu, Vikas Jain   +12 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

CHRONIC AFFECTS OF DETERGENT SURFACTANT (LINEAR ALKYLBENZENE SULFONATE / LAS) ON THE GROWTH AND SURVIVAL RATE OF SEA BASS (Lates calcalifer Bloch) LARVAE [PDF]

, 2008
Sea bass (Lates calcalifer Bloch) is one of the economically important marine fishes, which is getting more important for marine-culture. This fish is categorized as a euryhaline species, i.e. has a wide salinity tolerance range. This species can live in
Rejeki, Sri, Desrina, D, Mulyana, Andi Rahmat   +2 more
core   +1 more source

Physiological and Behavioral Effects of SiO₂ Nanoparticle Ingestion on Daphnia magna

Micromachines, 2021
The increasingly widespread use of engineered nanoparticles in medical, industrial, and food applications has raised concerns regarding their potential toxicity to humans and the environment.
Youngsam Kim, Afshin Samadi, Eun Heui Gwag, Jayoung Park, Minjeong Kwak, Jihoon Park, Tae Geol Lee, Young Jun Kim   +7 more
doaj   +1 more source

Fumonisin toxicity in ducks and turkeys [PDF]

, 2013
Les fumonisines (FBs) sont les principales mycotoxines produites par Fusarium verticillioides et Fusarium proliferatum, qui se retrouvent partout dans le monde dans le maïs et ses produits dérivés.
Benlashehr, Imad
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Acute and sub-chronic toxicity assessment and evaluation of the gastro-protective activity of polyherbal formulation “Mystomate4®” against gastric ulcer in experimental laboratory animal

Clinical Phytoscience, 2022
Background Ulcer remains a health challenge worldwide with antibiotics and proton pump inhibitors as major management therapy. The study investigated the acute, sub-chronic toxicity and gastrointestinal protective activity of a polyherbal formulation ...
Funmileyi Olubajo Awobajo, Margaret Oluwatoyin Sofidiya, Olayinka Taiwo Asekun, Babafemi Oluwole Familoni   +3 more
doaj   +1 more source

Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub‐acute toxic effects and no sub‐chronic toxicity [PDF]

Plant Biotechnology Journal, 2012
SummaryMultivitamin corn is a novel genetically engineered variety that simultaneously produces high levels of β‐carotene, ascorbate and folate, and therefore has the potential to address simultaneously multiple micronutrient deficiencies caused by the lack of vitamins A, B9 and C in developing country populations.
Arjó Pont, Gemma, Capell Capell, Teresa, Matias-Guiu, Xavier, Zhu, Changfu, Christou, Paul, Piñol Felis, Carme   +5 more
openaire   +3 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Evaluation of Toxic Properties of New Glycopeptide Flavancin on Rats

Pharmaceuticals, 2022
Glycopeptide antibiotics have side effects that limit their clinical use. In view of this, the development of glycopeptides with improved chemotherapeutic properties remains the main direction in the search for new antibacterial drugs.
Michael I. Treshchalin, Vasilisa A. Polozkova, Elena I. Moiseenko, Helen M. Treshalina, Andrey E. Shchekotikhin, Eleonora R. Pereverzeva   +5 more
doaj   +1 more source