Results 71 to 80 of about 3,864,827 (278)

Toxicological evaluation of subchronic use of pioglitazone in mice [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Pioglitazone (Actos) is one of the most controversial recent oral antidiabetic drugs. It was originally authorized in the European Union in 2000, and approved as an oral monotherapy for overweight second type of diabetic patients in 2002 ...
Said Said Elshama, Ayman El-Meghawry El-Kenawy, Hosam-Eldin Hussein Osman   +2 more
doaj  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Assessment of Sub Chronic Toxicity of Sonchus cornutus in Rats

Advances in Research, 2019
Aim: To assess the toxicity of the aqueous extract of Sonchus cornutus in Wistar albino rats. Methodology: The aqueous extract of Sonchus cornutus aerial part was administered orally to rats in group 2, 3 and 4 at a dose of 50, 500 and 2000 mg/ kg, respectively for four weeks whereas, group 1 was kept as a control. The animals were observed daily
Halima Mohamed Osman, Hassan Elsubki Khalid, Abdel Rahim Mohamed El Hussein, Hayat Mahgoub Farah   +3 more
openaire   +2 more sources

Acute and sub-chronic toxicity studies of aqueous extract of Icacina trichantha Oliv. leaves in rodents

, 2018
This study evaluated the acute and sub-chronic oral toxicity of aqueous extract of the leaves of Icacina trichantha Oliv. The powdered leaves (2 kg) were extracted by decoction in 2 L of distilled water to obtain the aqueous extract.
Idu, M, Igbe, I, Timothy, O, Eze, G.I., Edosuyi, O   +4 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Effects of the discharge plan on the caregiving load of people with chronic disease: Quasi-experimental study

, 2023
Hospitalization due to non-transmissible chronic disease (NTCD) affects people and health institutions negatively. Healthcare systems need integral strategies to minimize this impact.
Sánchez Herrera B., Guevara Lozano, Maryory, Pulido Barragán S.P., Carvajal Carrascal G., Fuentes Ramírez A.   +4 more
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Acute and sub-chronic toxicological evaluation of ethanol extract of Solanum trilobatum Linn. [PDF]

Research Journal of Pharmacognosy, 2018
Background and objectives: Solanum trilobatum plant parts such as berries and flowers are normally used for the treatment of respiratory illnesses. The toxicity profile of the plant and its parts are not clear.
S. Parasuraman*, L. Yu Ren, B. Lau Chik Chuon, S. Wong Kah Yee   +3 more
doaj