Results 61 to 70 of about 3,864,827 (278)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Acute, subacute, and sub‐chronic toxicity evaluation of Bletilla formosana tubers in rats

Food Safety and Health
Bletilla formosana (Hayata) Schltr. is an important economic medicinal and edible plant in China. Its tubers (BFTs) are traditionally consumed as a beverage and canned foods for promoting human health.
Yongchao Wang, Jian Zhang, Tianrui Zhao, Jianxin Cao, Afsar Khan, Zhengxuan Wang, Yaping Liu, Guiguang Cheng   +7 more
doaj   +1 more source

Research needs for an improved primary care response to chronic non-communicable diseases in Africa. [PDF]

, 2010
With non-communicable diseases (NCDs) projected to become leading causes of morbidity and mortality in developing countries, research is needed to improve the primary care response, especially in sub-Saharan Africa.
Harries, AD, Grosskurth, H, J. Sekajugo, A. D. Harries, H. Grosskurth, Maher, D, Sekajugo, J, D. Maher   +7 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Chemical profile and in vivo toxicity evaluation of unripe Citrus aurantifolia essential oil

Toxicology Reports, 2019
Citrus aurantifolia (Christm.) Swingle (syn. C. MEDICA var. ACIDA Brandis) (family: Rutaceae) essential oil is one of the cheapest oils found in local markets.
Christian K. Adokoh, Du-Bois Asante, Desmond O. Acheampong, Yohei Kotsuchibashi, Francis A. Armah, Ignatius H. Sirikyi, Keisuke Kimura, Edward Gmakame, Sey Abdul-Rauf   +8 more
doaj   +1 more source

Evaluation acute and sub-chronic toxicity assessments of Oleo-gum Resin of Ferula assa-foetida L. in Wistar rats [PDF]

Journal of Medicinal Plants, 2023
Background: Ferula assa-foetida is an herbaceous plant from Apiaceae family. Several pharmacological effects of oleo-gum resin of this plant were introduced in modern and traditional medicines such as digestive, antimicrobial, anti-diabetic, appetizing ...
Zahra Tofighi, Razieh Mohammad Jafari, Masoud Besati, Mostafa Pirali Hamedani, Abbas Hadjiakhoondi, Zahra Baharipour, Ahmad Jariani, Zahra Moiin, Saeed Tavakoli, Saied Goodarzi   +9 more
doaj  

Multiple Targets of Toxicity in Environmental Exposure to Low-Dose Cadmium

Toxics, 2022
Dietary assessment reports and population surveillance programs show that chronic exposure to low levels of environmental cadmium (Cd) is inevitable for most people, and adversely impacts the health of children and adults.
Soisungwan Satarug, Glenda C. Gobe, David A. Vesey   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Toxicological Effects of Leachates Extracted from Photocatalytic Concrete Blocks with Nano-TiO₂ on Daphnia magna

Nanomaterials
The incorporation of titanium dioxide nanoparticles into concrete blocks for paving adds photocatalytic functionality to the cementitious matrix, providing self-cleaning and pollutant-degrading properties.
Fernanda Facin, João Victor Staub de Melo, Rodrigo Costa Puerari, William Gerson Matias   +3 more
doaj   +1 more source