Results 111 to 120 of about 95,299 (308)

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells

Cells
The transmembrane proteoglycan syndecan-4 is known to be involved in the hypertrophic response to pressure overload. Although multiple downstream signaling pathways have been found to be involved in this response in a syndecan-4-dependent manner, there ...
Thea Parsberg Støle, Marianne Lunde, Katja Gehmlich, Geir Christensen, William E. Louch, Cathrine Rein Carlson   +5 more
doaj   +1 more source

Proteomic analysis of subcellular fractions during RNA virus replication.

, 2015
(A) Venn diagram of total numbers of proteins identified in mock or virus samples in all biochemical fractions from Huh7 cells (mock or replicating HCV RNA) and from PH5CH8 cells (mock or after 8h of SenV infection).
Samantha Badil (697284), Courtney Wilkins (106039), Stacy M. Horner (178713), Michael Gale Jr. (106064), Jason Iskarpatyoti (697285)   +4 more
core   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Subcellular Fractionation v1

To isolate total cell lysate into cytosolic and mitochondrial, soluble vs insoluble fractions.
Szu-Chi Liao, Mohamed Taha Moutaoufik, Ken Nakamura   +2 more
openaire   +1 more source

Binding of Dexamethasone by The Subcellular Fractions of Mouse Epidermis and Dermis

, 1977
The binding of the potent anticarcinogenic agent, dexamethasone, to mouse epidermal and dermal subcellular fractions was investigated. When applied to mouse skin, 3H-labeled dexamethasone remained associated, after extensive dialysis, with epidermal and ...
James A Schwarz, Thomas J Slaga, Sara. Thompson, Thompson, Sara., Schwarz, James A, Slaga, Thomas J   +5 more
core   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Benoxacor is enantioselectively metabolized by rat liver subcellular fractions. [PDF]

Chem Biol Interact, 2020
Simonsen D, Cwiertny DM, Lehmler HJ.
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Analysis of the Subcellular Phosphoproteome Using a Novel Phosphoproteomic Reactor

, 2010
Protein phosphorylation is an important post-translational modification involved in the regulation of many cellular processes. Mass spectrometry has been successfully used to identify protein phosphorylation in specific pathways and for global ...
Elisma, Fred, Zhou, Hu, Figeys, Daniel, Wright, Theodore G., Zou, Hanfa, Zhou, Houjiang, 邹汉法, Hou, Weimin, Tian, Ruijun, Daniel Figeys, Denis, Nicholas J.   +10 more
core   +1 more source