Results 71 to 80 of about 22,248,138 (428)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Modulation by Substance P in the Lamprey Spinal Cord [PDF]
, 2013 Neuromodulation is a key element for animal adaptation to environmental circumstances. Neuromodulators can alter the output of a physiological system by acting on the motor circuit by transforming intrinsic firing properties and altering synaptic ...
Thörn Pérez, Carolina
core +1 more source
Studies on the syntheses of β-carboline alkaloids brevicarine and brevicolline
Beilstein Journal of Organic ChemistryA new total synthesis of the β-carboline alkaloid brevicarine is disclosed. The synthesis was carried out starting from an aromatic triflate key intermediate, allowing the introduction of various substituents into position 4 of β-carboline by cross ...
Benedek Batizi +6 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 1997 We investigated the long-lasting effect of peripheral injection of the neuropeptide substance P (SP) and of some N- or C-terminal SP fragments (SPN and SPC, respectively) on retention test performance of avoidance learning. Male Wistar rats (220 to 280 g)
C. Tomaz, A.C.F. Silva, P.J.C. Nogueira
doaj +1 more source
Substance P Regulation in Epilepsy [PDF]
Current Neuropharmacology, 2017 Epilepsy is a common neurological disease characterized by abnormal temporary discharge of neurons in the central nervous system. In recent years, studies have revealed the localization and changes in the density of neuropeptides, such as substance P (SP) in the pathogenesis of epilepsy. This review is a concise overview of SP and their physiologic and
Guangfan Chi +4 more
openaire +3 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Model of graphene nanobubble: combining classical density functional and elasticity theories [PDF]
, 2019 A graphene nanobubble consists of a graphene sheet, an atomically flat substrate and a substance enclosed between them. Unlike conventional confinement with rigid walls and a fixed volume, the graphene nanobubble has one stretchable wall, which is the graphene sheet, and its volume can be adjusted by changing the shape.
arxiv +1 more source
Mechanism of action of substance P [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 1974 Synthetic substance P (SP) raises glycine levels both in the brain and in the spinal cord. The synthetic polypeptide, as well as the single amino acid, abolishes motor hyperactivity induced by β,β′-iminodipropionitrile in mice. The amino acid is effective event at very low intrinsic glycine levels, a condition where the polypeptide fails to act.
M. Stern, Sabira Ćatović, P. Stern
openaire +3 more sources
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Outcomes For Street Children and Youth Under Multidisciplinary Care in a Drop-In Centre in Tegucigalpa, Honduras [PDF]
, 2010 BACKGROUND: There is little evidence to describe the feasibility and outcomes of services for the care of street children and youth in low-income countries.
Briceño-Leon R. +7 more
core +2 more sources