Results 71 to 80 of about 1,878,278 (369)

Words Matter: Reducing Stigma in Online Conversations about Substance Use with Large Language Models [PDF]

In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing (EMNLP); pages 9139 - 9156
Stigma is a barrier to treatment for individuals struggling with substance use disorders (SUD), which leads to significantly lower treatment engagement rates. With only 7% of those affected receiving any form of help, societal stigma not only discourages individuals with SUD from seeking help but isolates them, hindering their recovery journey and ...
arxiv   +1 more source

Attitudes Towards Substance Use: A Potential Mechanism in the Relationship Between Conduct Disorder and Substance Use in Detained Youth [PDF]

, 2016
poster abstractBackground: There is a well-established relationship between conduct disorder and substance use, particularly in detained youth. Attitudes toward substance use predict alcohol and marijuana use; however, little research has investigated
Aalsma, Matthew, Cyders, Melissa A., Hershberger, Alexandra, Kolp, Haley   +3 more
core  

Associations between polygenic risk for psychiatric disorders and substance involvement [PDF]

, 2016
Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied.
Agrawal, Arpana, Bierut, Laura J, Bogdan, Ryan, Bucholz, Kathleen K, Carey, Caitlin E, Hartz, Sarah M, Lynskey, MIchael T, Nelson, Elliot C   +7 more
core   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Patient evaluation of a smartphone application for telehealth care of opioid use disorder

Addiction Science & Clinical Practice, 2022
Background People with opioid use disorder (OUD) face barriers to entering and remaining in life-saving treatment (e.g., stigma, detrimental interactions with health care, and privacy concerns).
Jordon D. Bosse, Kim Hoffman, Katharina Wiest, P. Todd Korthuis, Ritwika Petluri, Kellie Pertl, Stephen A. Martin   +6 more
doaj   +1 more source

Lifting the Burden of Addiction: Philanthropic Opportunities to Address Substance Use Disorders in the United States [PDF]

, 2015
Substance use disorders (SUDs), also known as substance abuse or addiction, affect an estimated 20 million or more adolescents and adults in the U.S. This guidance provides philanthropic funders with the tools & information to reduce immediate harm from ...
Cecily Wallman-Stokes, Götz Bechtolsheimer, Jacob Appel, Jennifer Gable, Jessica Chiu, Katherina Rosqueta, Rebecca Hobble   +6 more
core  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Identifying Early Warning Signs: Addressing Youth Substance Use [PDF]

, 2015
Of high school students 35 percent indicate they are current drinkers, 20 percent are binge drinkers, and 24 percent use marijuana. By the time they are seniors more than 20 percent will have used a prescription drug for a nonmedical purpose.

core  

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Classifying concepts via visual properties [PDF]

arXiv, 2021
We assume that substances in the world are represented by two types of concepts, namely substance concepts and classification concepts, the former instrumental to (visual) perception, the latter to (language based) classification. Based on this distinction, we introduce a general methodology for building lexico-semantic hierarchies of substance ...
arxiv