Results 111 to 120 of about 123,595 (337)

Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies

Scientific Reports
Nigrostriatal dopaminergic degeneration in alpha-synucleinopathies is indirectly reflected by low dopamine transporter (DaT) uptake through [123I]FP-CIT-SPECT. Bulk magnetic susceptibility ( $$\chi$$ ) in the substantia nigra, from MRI-based quantitative
Oliver C. Kiersnowski, Pietro Mattioli, Lucia Argenti, Laura Avanzino, Francesco Calizzano, Andrea Diociasi, Laura Falcitano, Chunlei Liu, Mattia Losa, Federico Massa, Silvia Morbelli, Beatrice Orso, Elisa Pelosin, Stefano Raffa, Matteo Pardini, Dario Arnaldi, Luca Roccatagliata, Mauro Costagli   +17 more
doaj   +1 more source

Unilateral substantia nigra lesions and schedule-induced polydipsia [PDF]

, 1986
Guy Mittleman, Elliot S. Valenstein
openalex   +1 more source

Magnetic Susceptibility and Area in the Subthalamic Nucleus Measured by QSM for Diagnosis of Progressive Supranuclear Palsy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Iron deposition and atrophy of the subthalamic nucleus (STN) have been reported in progressive supranuclear palsy (PSP). Quantitative susceptibility mapping (QSM), an advanced MRI technique, enables noninvasive assessment of the magnetic susceptibility of biological tissue and has been reported to have good ability to delineate STN.
Shotaro Haji, Wataru Sako, Kenta Hanada, Tomoyasu Matsubara, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada, Yuishin Izumi   +7 more
wiley   +1 more source

REVERSIBLE EFFECTS OF TETANUS TOXIN ON STRIATAL‐EVOKED RESPONSES AND [³H]‐γ‐AMINOBUTYRIC ACID RELEASE IN THE RAT SUBSTANTIA NIGRA [PDF]

, 1982
Graham L. Collingridge, John T. Davies
openalex   +1 more source

Parkinsonism and Dystonia Are Prevalent and Concomitant Movement Disorders in a Cohort of Patients with Rett Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Rett syndrome (RTT) is a rare neurodevelopmental disorder linked with MECP2 variants, frequently presenting with movement disorders (MDs). Objectives This study examined the frequency, types, and associations of MDs with RTT characteristics and severity.
Silvia Boeri, Giulia Prato, Maria Grazia Calevo, Silvia Casabona, Lino Nobili, Elisa De Grandis   +5 more
wiley   +1 more source

Differential Effects of Levodopa and Stimulation on Post‐Surgery Freezing of Gait in Subthalamic Nucleus Deep Brain Stimulation Parkinson's Disease Patients: A Clinical and Kinematic Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The long‐term efficacy of high‐frequency subthalamic nucleus deep brain stimulation (STN‐DBS) on freezing of gait (FOG) remains unclear. We aimed to study the mechanism and optimal therapeutic approach to long‐term post‐surgery FOG.
Raquel Barbosa, Paulo Bastos, Patrícia Pita Lobo, Catarina Correia Rodrigues, Anabela Valadas, Leonor Correia Guedes, Beatriz Mano, Sara Alberto, Vitor Paixão, Mário Miguel Rosa, Ricardo Matias, Daniel Martins, Marcelo Mendonça, Miguel Coelho   +13 more
wiley   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2019
Introduction: Prenatal stress causes brain alteration and prolongs effects on structure and function. Parkinson's is a progressive neurodegenerative disease And one of the factors motive Parkinson's is the Prenatal stress.
Toraj Mohammad zamani, Ahmadreza Movahedi, Elahe Arab ameri   +2 more
doaj  

A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin [PDF]

, 1992
G. D. Crawford, WD Le, RG Smith, WJ Xie, Enrico Stefani, S. H. Appel   +5 more
openalex   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

Movement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles, Dilan Athauda, Thomas R. Barber, Roger A. Barker, David T. Dexter, Susan Duty, Romy Ellis‐Doyle, Sonia Gandhi, Joel Handley, Edwin Jabbari, Keith Martin, Kevin McFarthing, Georgia Mills, Heather Mortiboys, Stephen Mullin, Rebecca Petty, Esther Sammler, Paula Scurfield, Simon R.W. Stott, George K. Tofaris, Li Wei, Caroline H. Williams‐Gray, Alan Wong, Marie‐Louise Zeissler, Richard K. Wyse, Camille B. Carroll, Thomas Foltynie, Oliver Bandmann, Anthony H.V. Schapira, on behalf of the EJS ACT‐PD Consortium   +29 more
wiley   +1 more source