Results 181 to 190 of about 129,849 (338)

Biotransformation of l‐DOPA to Dopamine in the Substantia Nigra of Freely Moving Rats: Effect of Dopamine Receptor Agonists and Antagonists [PDF]

, 1998
Sophie Sarre, Diederik Vandeneede, Guy Ebinger, Yvette Michotte   +3 more
openalex   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model. [PDF]

NPJ Parkinsons Dis
Murphy EK, Perl DP, Day RM, Iacono D.
europepmc   +1 more source

Differential Actions of Serotonin, Mediated by 5-HT_1Band 5-HT_2CReceptors, on GABA-Mediated Synaptic Input to Rat Substantia Nigra Pars Reticulata NeuronsIn Vitro [PDF]

, 1996
Ian M. Stanford, M.G. Lacey
openalex   +1 more source

Comparison of automated and manual approaches for microglial quantification and classification: A focus on the HALO digital pathology platform

Brain Pathology, EarlyView.
The Halo microglial activation module has not been formally validated in the literature. Comparison of this module with established methods revealed varied performance dependent on tissue thickness, highlighting the need for care to be taken when optimising image analysis parameters. Abstract Phenotypic changes in microglia have been linked to multiple
Laura M. Carr, Bianca Guglietti, Ing Chee Wee, Ian F. Musgrave, Sanam Mustafa, Frances Corrigan, Lyndsey E. Collins‐Praino   +6 more
wiley   +1 more source

GDNF receptor GFRα1 is necessary for the maintenance of dopaminergic neurons in the adult substantia nigra. [PDF]

PLoS One
Carrier-Ruiz A, Andersson A, Fernández-Suárez D, Ibáñez CF.   +3 more
europepmc   +1 more source

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade, Pierre‐Louis Bazin, Evgeniya Kirilina, Kerrin Pine, Andreas Herrler, Ronald L. A. W. Bleijs, J. Max Kros, Lysanne Groenewegen, Sanne M. M. Vermorgen, Laura E. Jonkman, Dick F. Swaab, Rawien Balesar, Nikolaus Weiskopf, Birte U. Forstmann   +13 more
wiley   +1 more source

Neuromelanin Contrast Optimization and Improved Visualization of the Substantia Nigra in a 3D Gradient-Echo Sequence With Magnetization Transfer. [PDF]

NMR Biomed
Andikoetxea BG, Martín-Bastida A, Vidorreta M, Rodríguez-Oroz MC, Soustelle L, Troalen T, Fernández-Seara MA.   +6 more
europepmc   +1 more source

Selective vulnerability of late-generated dopaminergic neurons of the substantia nigra in weaver mutant mice. [PDF]

, 1995
Shirley A. Bayer, Katherine V. Wills, L C Triarhou, Tatyana Verina, James D. Thomas, Bernardino Ghetti   +5 more
openalex   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source