Results 181 to 190 of about 123,595 (337)

Identifying Age‐Modulating Compounds Using a Novel Computational Framework for Evaluating Transcriptional Age

Aging Cell, EarlyView.
RNAge is a transcriptional based computational approach to measure changes in cellular age upon experimental manipulation. In silico screening of a database of transcriptional changes from drug perturbations identified a novel aging agent that was applied to an hPSC model of neurodegenerative disease to trigger a late‐onset phenotype.
Chao Zhang, Nathalie Saurat, Daniela Cornacchia, Sun Young Chung, Trisha Sikder, Adrianne Nemchik, Andrew Minotti, Lorenz Studer, Doron Betel   +8 more
wiley   +1 more source

Systemic Primary Carnitine Deficiency Presenting With Substantia Nigra and Basal Ganglia Injury: A Case Report. [PDF]

JIMD Rep
Saito T, Soma K, Kashisaka M, Iketani K, Matsumoto M, Ueda T, Nishiyama M, Maruyama A, Nakai R, Sakihama H, Kurosawa H, Morisada N, Kobayashi H, Ozaki K.   +13 more
europepmc   +1 more source

Neonatal hypoxic-ischemic or excitotoxic striatal injury results in a decreased adult number of substantia nigra neurons

, 1992
Robert E. Burke, Alfons Macaya, D. C. DeVivo, Nicholas J. Kenyon, Eileen Janec   +4 more
openalex   +1 more source

dVGLUT Is a Mediator of Sex Differences in Dopamine Neuron Mitochondrial Function Across Aging and in a Parkinson's Disease Model

Aging Cell, EarlyView.
We examined sex and regional differences in mitochondrial reactive oxygen species (ROS) generation and their implications for dopamine (DA) neuron resilience using the Drosophila model. We found: (1) higher basal ROS in males versus females; (2) age‐related ROS increases in both sexes; and (3) DA neuron‐specific dVGLUT RNAi knockdown raised ROS in ...
Silas A. Buck, Samuel J. Mabry, Tenzin Kunkhyen, Zilu Yang, Sophie A. Rubin, Jinting Yang, Claire E. J. Cheetham, Zachary Freyberg   +7 more
wiley   +1 more source

Efferent projections of the retrorubral nucleus to the substantia nigra and ventral tegmental area in cats as shown by anterograde tracing [PDF]

, 1996
M.P.M. Arts, H.J. Groenewegen, Jan G. Veening, A.R. Cools   +3 more
openalex   +1 more source

Characterisation of localised pigment accumulation in brains of eastern grey kangaroos (Macropus giganteus) after clinical disease due to chronic Phalaris species toxicosis

Australian Veterinary Journal, EarlyView.
A progressive tremorgenic syndrome characterised by ataxia and head nodding is well documented in sheep and cattle affected by chronic Phalaris toxicosis (CPT), and is increasingly documented in the eastern grey kangaroo {(EGK), Macropus giganteus} in southeastern Australia.
C El‐Hage, T Chen, L Tatarczuch, J Hufschmid, LF Skerratt, P Whiteley, N Davis, R Ploeg   +7 more
wiley   +1 more source

Interactions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra. [PDF]

J Neurochem
Fitzgerald JC, Sun Y, Reinecke F, Bauer E, Garaschuk O, Kahle PJ, Pfeiffer F.   +6 more
europepmc   +1 more source

Nerve growth factor (NGF) potentiates the changes in striatal proenkephalin mrnas subsequent to 6-hydroxydopamine-induced lesions of the substantia nigra

, 1990
Jean Lud Cadet, Jesús A. Angulo, Bruce S. McEwen   +2 more
openalex   +1 more source

Stereological analysis of cholinergic neurons within bilateral pedunculopontine nuclei in health and when affected by Parkinson's disease

Brain Pathology, EarlyView.
(A) PPN‐cholinergic neurons degenerate during PD. We stereologically counted their rostro‐caudal distribution in post‐mortem PPNs in health versus PD. (Bi) Serial PPN‐containing samples were cholinergic antibody‐DAB stained. (Bii) Only DAB‐stained neurons on green lines and inside the box were counted.
Puneet Kumar Sharma, Steve Gentleman, David Trevor Dexter, Ilse Sanet Pienaar   +3 more
wiley   +1 more source

Synaptic inhibition in the rat hippocampus in vivo following stimulation of the substantia nigra and ventral tegmentum.

, 1990
P M Spencer, H.V. Wheal
openalex   +2 more sources