Results 191 to 200 of about 123,595 (337)

Late‐onset multiple system atrophy: Neuropathological features associated with slow disease progression

open access: yesBrain Pathology, EarlyView.
Late‐onset multiple system atrophy (LO‐MSA; onset ≥75 years) shows milder degeneration of the striatonigral and olivopontocerebellar systems and serotonergic neurons in the ventrolateral medulla than usual‐age‐onset MSA with a similar disease duration. LO‐MSA may therefore exhibit slower pathological progression.
Misato Ozawa   +13 more
wiley   +1 more source

Interaction of Human Substantia Nigra Neuromelanin with Lipids and Peptides [PDF]

open access: bronze, 2000
Luigi Zecca   +5 more
openalex   +1 more source

Contribution of α‐synuclein cytopathologies to distinct seeding of misfolded α‐synuclein

open access: yesBrain Pathology, EarlyView.
This study investigated whether brain regions with distinct predominance of α‐synuclein (αSyn) cytopathologies show different αSyn seeding patterns in multiple system atrophy (MSA) and Lewy body disease (LBD), using an interdisciplinary approach. High seeding activity is observed in regions with oligodendrocytic‐predominant αSyn pathology in MSA.
Ain Kim   +4 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of intranasal insulin in a rat brain

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Understanding of the insulin‐mediated effects on signalling and metabolism is important not only for fundamental knowledge of insulin's action in the brain but also for elucidating the mechanism of therapeutic potential in neurodegenerative disorders with underlying brain metabolic dysfunction.
Jelena Osmanovic Barilar   +7 more
wiley   +1 more source

Substantia nigra degeneration in spinocerebellar ataxia 2 and 7 using neuromelanin-sensitive imaging. [PDF]

open access: yesEur J Neurol
Chougar L   +10 more
europepmc   +1 more source

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