Nurr1 Orchestrates Claustrum Development and Functionality
Advanced Science, Volume 13, Issue 13, 3 March 2026.Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan +12 more
wiley +1 more source
The Discovery of Phages in the Substantia Nigra and Its Implication for Parkinson's Disease. [PDF]
Research (Wash D C)Zhao Y +8 more
europepmc +1 more source
Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du +5 more
wiley +1 more source
Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories. [PDF]
Nat CommunSansalone L +5 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 13, 3 March 2026.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Correction: Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy. [PDF]
Acta Neuropathol CommunShin JH +7 more
europepmc +1 more source
Wearable Metamaterials with Embodied Intelligence for Programmable Control of Human Limbs Tremor
Advanced Intelligent Systems, Volume 8, Issue 3, March 2026.Resulting from alternating muscle contractions, tremors can severely limit human ability to perform everyday tasks like walking or talking, due to their disruptive nature. Medication and surgery may not always effectively address tremor control. A wearable device embodying programmable smart metamaterials with adaptable intelligence to meet the demand ...
Braion Barbosa de Moura +2 more
wiley +1 more source
Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy. [PDF]
Acta Neuropathol CommunShin JH +7 more
europepmc +1 more source
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION The locus coeruleus (LC), the first region to contain tau pathology in Alzheimer's disease (AD), releases norepinephrine, which has a neuroprotective role. We examined whether LC integrity relates to whole‐brain integrity and how AD biomarkers may moderate this relationship.
Emilie Foyard +9 more
wiley +1 more source