The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy [PDF]
, 2015 Özlem Akman +7 more
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Annals of the New York Academy of Sciences, EarlyView.Iron is crucial for brain functioning, but excessive levels can harm brain health. While previous studies support this, meta‐analytic evidence in Alzheimer's disease (AD) is limited. We performed a meta‐analysis of 23 MRI studies with 715 AD patients and 1130 healthy controls.
Marthe Mieling +2 more
wiley +1 more source
The spatial landscape of glial pathology and T cell response in Parkinson's disease substantia nigra. [PDF]
Nat CommunMa M +18 more
europepmc +1 more source
Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry
The Journal of Physiology, EarlyView.Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley +1 more source
Transcranial Sonographic Characteristics of Substantia Nigra in End-Stage Renal Disease Patients with Restless Legs Syndrome: A Diagnostic Marker Study. [PDF]
Diagnostics (Basel)Wang C, Zhan Z, Ding C, Zhang Y, Luo W.
europepmc +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima +9 more
wiley +1 more source
Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model. [PDF]
NPJ Parkinsons DisMurphy EK, Perl DP, Day RM, Iacono D.
europepmc +1 more source
Association of emotional and behavioral problems with the development of the substantia nigra, subthalamic nucleus, and red nucleus volumes and asymmetries from childhood to adolescence: A longitudinal cohort study [PDF]
Yanpei Wang +10 more
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High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra [PDF]
, 2019 Yu-Chia Kao +3 more
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Glia, Volume 74, Issue 2, February 2026.CD38 deficiency influences brain NAD/NAM metabolism. Global CD38 deficiency drives changes in astrocyte mitochondrial, metabolic, senescence, and neurodegenerative‐related genes. CD38 deficiency alters glial reactivity and astrocyte bioenergetics. ABSTRACT CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis.
S. Basak +15 more
wiley +1 more source