Cell Proliferation, Volume 58, Issue 6, June 2025.The regeneration of LC‐NE from pluripotent stem cells (PSCs) could significantly mitigate the progression of Neurodegenerative diseases and alleviate associated psychiatric disease symptoms, providing a new approach to the treatment of neurological diseases.
Yana Yang, Yunlong Tao
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Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease. [PDF]
Eur J NeurolWen J +22 more
europepmc +1 more source
Modulation of cardiac activity by tachykinins in the rat substantia nigra [PDF]
, 2001 Andrée Lessard, Réjean Couture
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Preferential superficial cortical layer activation during seizure propagation
Epilepsia, Volume 66, Issue 3, Page 929-941, March 2025.Abstract Objective Focal cortical seizures travel long distances from the onset zone, but the long‐distance propagation pathways are uncertain. In vitro and in vivo imaging techniques have investigated the local spread of seizures but did not elucidate long‐distance spread. Furthermore, classical studies in slices suggested seizure spread locally along
Anastasia Brodovskaya +4 more
wiley +1 more source
Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake
The FEBS Journal, EarlyView.Estrogen is regulated by the rate‐limiting enzyme aromatase. This study examines how neuroestrogens, estrogen produced in the brain, regulate appetite through the hypothalamus. Using ovariectomized, aromatase knockout, and brain‐specific aromatase‐restored mice, the study found that neuroestrogens suppress appetite by influencing genes like Mc4r.
Takanori Hayashi +8 more
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Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra. [PDF]
Alzheimers DementEhrenberg AJ +17 more
europepmc +1 more source
Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy
The FEBS Journal, EarlyView.Neurodegeneration is thought to arise due to the disruption of the protein homeostasis. In synucleinopathies, alterations in the levels of functional and aggregated aSyn lead to proteinopenia and proteinopathy, respectively. aSyn and β‐glucocerebrosidase are closely linked to lipid metabolism, impacting organelle function and lipidostasis.
Manuel Flores‐León, Tiago F. Outeiro
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Characterization of clock proteins in the substantia nigra and subthalamic nucleus of the Sapajus apella primate. [PDF]
Front NeuroanatGuissoni Campos LM +12 more
europepmc +1 more source