Results 221 to 230 of about 71,981 (295)

Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson's disease. [PDF]

Brain Commun
Pasquini J, Firbank MJ, Best L, Foster V, Stewart C, Silani V, Durcan R, Roberts G, Petrides G, Ceravolo R, Brooks DJ, Anderson KN, Pavese N.   +12 more
europepmc   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, Volume 45, Issue 5, Page 1423-1451, September 2025.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

A Single-Cell Atlas of the Substantia Nigra Reveals Therapeutic Effects of Icaritin in a Rat Model of Parkinson's Disease. [PDF]

Antioxidants (Basel)
Wu H, Zhang ZH, Zhou P, Sui X, Liu X, Sun Y, Zhao X, Pu XP.   +7 more
europepmc   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, Volume 45, Issue 5, Page 1407-1422, September 2025.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson's disease model mice. [PDF]

Cell Death Dis
Song W, Zhou ZM, Zhang LL, Shu HF, Xia JR, Qin X, Hua R, Zhang YM.   +7 more
europepmc   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
wiley   +1 more source

Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies. [PDF]

Alzheimers Res Ther
Planas-Ballvé A, Rios J, Gea M, Rabaneda-Lombarte N, Ispierto L, Grau L, Jiménez M, Cáceres C, Martínez S, Beyer K, Álvarez R, Pastor P, Vilas D.   +12 more
europepmc   +1 more source

Zebrafish as a Versatile Model Organism: From Tanks to Treatment

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
The zebrafish, with its optical transparency and genetic tractability, serves as a versatile in vivo platform for biomedical research. This review underscores its significance in modeling a wide spectrum of human diseases—from cancer to metabolic disorders—and in leveraging cutting‐edge technologies like CRISPR and TALENs.
Rupali Srivastava, Kalyani Eswar, Sasvat Sayee Ram Ramesh, Akshit Prajapati, Tanvi Sonpipare, Apoorva Basa, Mounika Gubige, Sribala Ponnapalli, Shashidhar Thatikonda, Aravind Kumar Rengan   +9 more
wiley   +1 more source

Quantitative susceptibility mapping in magnetically inhomogeneous tissues

Magnetic Resonance in Medicine, Volume 94, Issue 3, Page 1044-1059, September 2025.
Abstract Purpose Conventional quantitative susceptibility mapping (QSM) methods rely on simplified physical models that assume isotropic and homogeneous tissue properties, leading to artifacts and inaccuracies in biological tissues. This study aims to develop and evaluate DEEPOLE, a deep learning–based method that incorporates macroscopically ...
Thomas Jochmann, Fahad Salman, Michael G. Dwyer, Niels Bergsland, Robert Zivadinov, Jens Haueisen, Ferdinand Schweser   +6 more
wiley   +1 more source

Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson's substantia nigra. [PDF]

Commun Biol
Brooks J, Everett J, Hill E, Billimoria K, Morris CM, Sadler PJ, Telling N, Collingwood JF.   +7 more
europepmc   +1 more source