Results 231 to 240 of about 71,981 (295)

A case of depression with psychotic features associated with hemoglobin Manukau mutation

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 3, September 2025.
Abstract Background It is pertinent to investigate organic possibilities in acute presentation of mental illness. Iron‐deficiency anemia has long been established to cause symptoms of major depressive disorder. The association between depression and hemolytic anemia and hemochromatosis is less understood.
Zhonghao Zhang, Alana Greenberg, Linda Rose, Thilini Jayasooriya, Naveen Thomas, Soumitra Das   +5 more
wiley   +1 more source

Corticobasal degeneration preceded by cognitive impairment and apathy: An autopsy case report

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 3, September 2025.
Abstract Background Corticobasal degeneration (CBD) presents with a range of clinical phenotypes, making diagnosis challenging. We report the clinical course of a patient with autopsy‐confirmed CBD who initially presented with cognitive impairment and apathy, without motor symptoms.
Shoma Hirose, Ryota Kobayashi, Shigeki Hatakeyama, Shinobu Kawakatsu, Akihito Suzuki, Chiaki Kawanishi, Kumiko Utsumi   +6 more
wiley   +1 more source

A deep cellular atlas of the human ventral substantia nigra in Parkinson’s identifies a genetic and molecular overlap with Type 2 Diabetes

Volpato V, Menassa DA, Sheshadri P, Giussani S, Rokicki M, Cardo LF, Bafaloukou M, Schalkamp A, Zaremba A, Monzón-Sandoval J, Vinh N, Morgan J, Hu MT, Miners S, Wade-Martins R, Sandor C, Parkkinen L, Webber C.   +17 more
europepmc   +1 more source

Advancements in understanding substantia nigra hyperechogenicity via transcranial sonography in Parkinson's disease and its clinical implications. [PDF]

Front Neurol
Zhang YY, Jiang XH, Zhu PP, Zhuo WY, Liu LB.   +4 more
europepmc   +1 more source

Stereological analysis of cholinergic neurons within bilateral pedunculopontine nuclei in health and when affected by Parkinson's disease

Brain Pathology, Volume 35, Issue 5, September 2025.
(A) PPN‐cholinergic neurons degenerate during PD. We stereologically counted their rostro‐caudal distribution in post‐mortem PPNs in health versus PD. (Bi) Serial PPN‐containing samples were cholinergic antibody‐DAB stained. (Bii) Only DAB‐stained neurons on green lines and inside the box were counted.
Puneet Kumar Sharma, Steve Gentleman, David Trevor Dexter, Ilse Sanet Pienaar   +3 more
wiley   +1 more source

Late‐onset multiple system atrophy: Neuropathological features associated with slow disease progression

Brain Pathology, Volume 35, Issue 5, September 2025.
Late‐onset multiple system atrophy (LO‐MSA; onset ≥75 years) shows milder degeneration of the striatonigral and olivopontocerebellar systems and serotonergic neurons in the ventrolateral medulla than usual‐age‐onset MSA with a similar disease duration. LO‐MSA may therefore exhibit slower pathological progression.
Misato Ozawa, Rie Saito, Takuya Konno, Yasuko Kuroha, Tetsuhiko Ikeda, Akio Yokoseki, Takashi Tani, Tomoe Sato, Jiro Idezuka, Reiji Koide, Shigeru Fujimoto, Osamu Onodera, Mari Tada, Akiyoshi Kakita   +13 more
wiley   +1 more source

Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta. [PDF]

Addict Neurosci
Conrad WS, Oriol L, Kollman GJ, Faget L, Hnasko TS.   +4 more
europepmc   +1 more source

Pharmacokinetics and pharmacodynamics of intranasal insulin in a rat brain

British Journal of Pharmacology, Volume 182, Issue 17, Page 4020-4040, September 2025.
Abstract Background and Purpose Understanding of the insulin‐mediated effects on signalling and metabolism is important not only for fundamental knowledge of insulin's action in the brain but also for elucidating the mechanism of therapeutic potential in neurodegenerative disorders with underlying brain metabolic dysfunction.
Jelena Osmanovic Barilar, Leonarda Vlahov, Ana Babic Perhoc, Jan Homolak, Davor Virag, Eugenio Barone, Melita Salkovic‐Petrisic, Ana Knezović   +7 more
wiley   +1 more source

The cerebellum directly modulates the substantia nigra dopaminergic activity. [PDF]

Nat Neurosci
Washburn S, Oñate M, Yoshida J, Vera J, Bhuvanasundaram R, Khatami L, Nadim F, Khodakhah K.   +7 more
europepmc   +1 more source

Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D4R) Antagonist in vitro Tool compounds

ChemMedChem, Volume 20, Issue 15, August 2, 2025.
The work presents details of the efforts to design and characterize novel D4 inhibitors. A new 4,4‐difluoropiperidine ether series that confers improved potency and selectivity for D4 versus the other dopamine receptor subtypes is identified. Extensive structure‐activity relationship around this privileged group identifies the key structural changes to
Saeedeh Saeedi, Sumaiya Nahid, Anish K. Vadukoot, Corey R. Hopkins   +3 more
wiley   +1 more source