Results 231 to 240 of about 132,532 (337)

Increased iron deposition in putamen and substantia nigra correlates with cognitive function in cerebral small vessel disease: A quantitative susceptibility mapping study. [PDF]

J Cereb Blood Flow Metab
Feng M, Wang Y, Liu X, Zhang S, Lu W, Wang T, Song H, Lu J.   +7 more
europepmc   +1 more source

AAV‐PHP.eB Peripheral Delivery and Central Expression in Cre Mice

Journal of Comparative Neurology, Volume 534, Issue 1, January 2026.
Retro‐orbital injection of AAV‐PHP.eB‐FLEX‐tdTomato into four different strains of Cre mice produced various and distinct patterns of transduction efficiency and tropism across brain regions and cell types. We found many target neurons expressing tdTomato in most but not all strains, along with a low level of nonspecific (Cre‐independent) expression ...
Haidong Zhu, Joel C. Geerling
wiley   +1 more source

Unraveling the complexity of neurodegeneration: heterogeneous damage patterns of locus coeruleus and substantia nigra in Alzheimer's disease. [PDF]

Alzheimers Dement
Tang C, Yang J, Lei X, Zhang M, Chen Y, Peng X, He D.   +6 more
europepmc   +1 more source

Engineering Liposomes for Neurodegenerative Diseases: Targeted Delivery and Regenerative Potential

ChemNanoMat, Volume 12, Issue 1, January 2026.
Liposomal nanocarriers offer therapeutic promise for neurodegenerative diseases by encapsulating diverse agents such as neurotrophic factors and mRNA while targeting the blood‐brain barrier. Designed to stimulate neuronal repair and restore function, these lipid vesicles advance strategies for optimized design and central nervous system delivery ...
Oybek Ashirov, Shakhnoz Azimova, Borislav Angelov, Angelina Angelova   +3 more
wiley   +1 more source

METABOLIC CHANGES INDUCED BY BUSHENHUOXUE GRANULES ON STRIATUM AND SUBSTANTIA NIGRA IN A RAT MODEL OF PARKINSON’S DISEASE

, 2017
Yunxia Guo, Junxiu Zhang, Shaodan Li, Yin Zhang⋆, Yi Liu, Minghui Yang   +5 more
openalex   +2 more sources

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Yan Zhao, Yixin Fu, Tianhao Liu, Zanhao Yang, Zhengzhong Yang, Bingqing Chen, Lipeng Zhou, Juntao Yang, Duo Chen, Xiaojiao Han, Ying Tang, Jiang‐Hong Ye, Chao‐Yu Miao, Rao Fu   +13 more
wiley   +1 more source

Preventing Neurons and Glial Cells Destruction in Substantia Nigra Pars Compacta and Striatum Using St. John's Wort and Stem Cells on Parkinson's Model. [PDF]

Brain Behav
Farzadmanesh H, Sameni H, Ghanbari A, Vafaei AA, Khaleghian A, Mirmohammadkhani M, Ghahari L, Shokri A, Safari M.   +8 more
europepmc   +1 more source

Anti‐Neuroinflammation Activity of Essential Oils and Fatty Acids

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Neuroinflammation plays a pivotal role in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Current pharmacological interventions, such as NSAIDs and corticosteroids, are limited by systemic toxicity and insufficient efficacy in targeting chronic neuroinflammatory processes.
Zelong Jin, Yige Song, Ahmed Attia Ahmed Abdelmoaty, Feng Lin, Jiujun Li, Xianyang Chen   +5 more
wiley   +1 more source

Substantia Nigra Iron Deposition in Lewy Body Disease: A Magnetic Resonance Imaging and Neuropathology Study. [PDF]

Mov Disord
Diaz-Galvan P, Przybelski SA, Lesnick TG, Murray ME, Nguyen A, Reichard RR, Dickson DW, Ono D, Senjem ML, Schwarz CG, Gunter J, Lowe V, Forsberg LK, Fields JA, Savica R, Graff-Radford J, Ramanan VK, Jones D, Botha H, St Louis EK, Knopman D, Day GS, Graff-Radford N, Kremers W, Petersen RC, Jack CR, Ferman TJ, Boeve BF, Kantarci K.   +28 more
europepmc   +1 more source