Results 1 to 10 of about 81,530 (252)

Efficacy Evaluation of an E2 Subunit Vaccine Against Highly Virulent Classical Swine Fever Virus Strain [PDF]

Vaccines
Background/Objectives: Classical swine fever (CSF) is listed by the World Organisation for Animal Health as a highly devastating and contagious pig disease, causing severe economic losses to the swine industry.
Yu-Chieh Chen, Chi-Chih Chen, Wen-Bin Chung, Yen-Li Huang, Guan-Ming Ke, Hso-Chi Chaung   +5 more
doaj   +2 more sources

Fusion membrane proteins derived subunit vaccine candidates effectively protect against Mycoplasma bovis challenge in mice [PDF]

BMC Veterinary Research
Mycoplasma bovis (M. bovis) is the causative agent of bovine mycoplasmosis, a disease that can lead to respiratory issues, otitis media, mastitis, and arthritis in cattle and causes huge economic losses to the cattle breeding industry.
Yong Xuan Wang, Hong Song Cheng, Jun Yue, Qian Hu, Shuai Bo Han, Ying Fen Li, Yu Jie Chen, Er Peng Zhu, Zhen Tao Cheng   +8 more
doaj   +2 more sources

A QS21+ CpG-Adjuvanted Rabies Virus G Subunit Vaccine Elicits Superior Humoral and Moderate Cellular Immunity [PDF]

Vaccines
Background: Rabies remains a fatal zoonotic disease caused by rabies virus (RABV), posing substantial global health challenges. Current vaccine production faces challenges in manufacturing efficiency and cost-effectiveness. The RABV glycoprotein (RABV-G)
Han Cao, Hui Li, Wenzhi Liu, Ning Luan, Jingping Hu, Meijun Kong, Jie Song, Cunbao Liu   +7 more
doaj   +2 more sources

LDH as an adjuvant makes Brucella outer-membrane vesicles and outer-membrane vesicle-associated proteins highly protective in mice [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Existing Brucella vaccines are attenuated and can cause vaccine-associated brucellosis; and these safety concerns have affected their application.
Xiaoyu Deng, Jinke He, Jinfeng Xu, Yueli Wang, Jihai Yi, Huan Zhang, Yong Wang, Zhen Wang, Chuangfu Chen   +8 more
doaj   +1 more source

Comparison of the Immune Effects of an mRNA Vaccine and a Subunit Vaccine against Herpes Zoster Administered by Different Injection Methods

Vaccines, 2023
Previous studies have shown that the herpes zoster subunit vaccine Shingrix™ performs well in clinical trials. However, the key ingredient in its adjuvant, QS21, is extracted from rare plants in South America, so vaccine production is limited.
Kangyang Lin, Han Cao, Ning Luan, Yunfei Wang, Jingping Hu, Cunbao Liu   +5 more
doaj   +1 more source

Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies

Acta Pharmaceutica Sinica B, 2023
Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs.
Yingying Hou, Min Chen, Yuan Bian, Xi Zheng, Rongsheng Tong, Xun Sun   +5 more
doaj   +1 more source

Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human

Frontiers in Immunology, 2022
Under the background of the severe human health and world economic burden caused by COVID-19, the attenuation of vaccine protection efficacy, and the prevalence and immune escape of emerging variants of concern (VOCs), the third dose of booster ...
Yuwei Zhang, Mingxiao Yao, Xingyu Guo, Shanshan Han, Shu Zhang, Jinzhong Zhang, Xiangkun Jiang, Jianxing Wang, Ming Fang, Shuang Wang, Bo Pang, Xiaolin Liu, Zengqiang Kou, Xiaolin Jiang, Xiaolin Jiang   +14 more
doaj   +1 more source

Immunogenicity and protective efficacy of OmpA subunit vaccine against Aeromonas hydrophila infection in Megalobrama amblycephala: An effective alternative to the inactivated vaccine

Frontiers in Immunology, 2023
Aeromonas hydrophila is a kind of zoonotic pathogen, which can cause bacterial septicemia in fish and bring huge economic losses to global aquaculture. Outer membrane proteins (Omps) are conserved antigens of Aeromonas hydrophila, which can be developed ...
Minying Zhang, Ting Zhang, Yang He, Hujun Cui, Hujun Cui, Hong Li, Zehua Xu, Xu Wang, Yunlong Liu, Hongping Li, Xiaoheng Zhao, Xiaoheng Zhao, Hanliang Cheng, Hanliang Cheng, Jianhe Xu, Jianhe Xu, Xiangning Chen, Xiangning Chen, Zhujin Ding, Zhujin Ding   +19 more
doaj   +1 more source

Acute retinal necrosis following recombinant subunit varicella-zoster virus vaccine

American Journal of Ophthalmology Case Reports, 2020
Purpose: Previously, secondary prevention of herpes zoster required live-attenuated vaccination, which is contraindicated in immunocompromised populations.
Rebecca I. Chen, Jordan D. Deaner, Sunil K. Srivastava, Careen Y. Lowder   +3 more
doaj   +1 more source

Evaluation of immunogenicity of gene-deleted and subunit vaccines constructed against the emerging pseudorabies virus variants

Virology Journal, 2023
Background Pseudorabies (PR) (also called Aujeszky’s disease, AD) is a serious infectious disease affecting pigs and other animals worldwide. The emergence of variant strains of pseudorabies virus (PRV) since 2011 has led to PR outbreaks in China and a ...
Hong-liang Zhang, Rui-hua Zhang, Gang Liu, Gui-mei Li, Feng-xue Wang, Yong-jun Wen, Hu Shan   +6 more
doaj   +1 more source