Results 11 to 20 of about 1,122,864 (370)

LDH as an adjuvant makes Brucella outer-membrane vesicles and outer-membrane vesicle-associated proteins highly protective in mice [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Existing Brucella vaccines are attenuated and can cause vaccine-associated brucellosis; and these safety concerns have affected their application.
Xiaoyu Deng, Jinke He, Jinfeng Xu, Yueli Wang, Jihai Yi, Huan Zhang, Yong Wang, Zhen Wang, Chuangfu Chen   +8 more
doaj   +1 more source

PRRSV GP4 subunit vaccine combined with adenovirus heterologous prime-boost immunization strategy induced a significant immune response in mice [PDF]

BMC Veterinary Research
Background The porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause widespread infections in the pig industry worldwide. Currently, multiple PRRSV vaccine candidates are in preclinical or clinical trials, and each has different ...
Honghuan Li, Wenxiang Zhang, Wenxing Wang, Yanjie Qiao, Mingguo Xu, Ziwei Liu, Xiaoxiao Gu, Aodi Wu, Zhongchen Ma, Chuangfu Chen, Wei Zhang   +10 more
doaj   +2 more sources

Precision-engineering of subunit vaccine particles for prevention of infectious diseases

Frontiers in Immunology, 2023
Vaccines remain the best approach for the prevention of infectious diseases. Protein subunit vaccines are safe compared to live-attenuated whole cell vaccines but often show reduced immunogenicity.
Shuxiong Chen, Saranya Pounraj, N. Sivakumaran, Anjali Kakkanat, Gayathri Sam, M. Kabir, B. Rehm   +6 more
semanticscholar   +1 more source

Immunoinformatics Approach to Design Novel Subunit Vaccine against the Epstein-Barr Virus

Microbiology spectrum, 2022
Epstein-Barr virus (EBV) vaccines have been developing for over 30 years, but polyphyletic and therapeutic vaccines have failed to get licensed. Our vaccine surpasses the limitations of many such vaccines and remains very promising, which is crucial ...
Abu Tayab Moin, R. Patil, Tahani Tabassum, Yusha Araf, M. Ullah, Hafsa Jarin Snigdha, Tawfiq G. Alam, Safwan Araf Alvey, Bashudev Rudra, S. Mina, Y. Akter, Jingbo Zhai, C. Zheng   +12 more
semanticscholar   +1 more source

A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Science Translational Medicine, 2021
A SARS-CoV-2 spike protein subunit vaccine induced humoral and cellular immune responses that protected hamsters against infection and prevented transmission.
Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hua-long Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingwen Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, M. Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yu Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Q. Zheng, Shaowei Li, Yixin Chen, T. Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Q. Yuan, Y. Guan, N. Xia   +35 more
semanticscholar   +1 more source

CD40 Ligand Potentiates Immunogenecity of Mycoplasma pneumoniae Subunit Vaccine Candidate in a Murine Model [PDF]

Curr Issues Mol Biol
Jinqi Shu, Gaojian Li, Jianhong Shu, Huapeng Feng, Yulong He   +4 more
openalex   +2 more sources

Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine

Science Translational Medicine, 2022
Despite the remarkable efficacy of COVID-19 vaccines, waning immunity and the emergence of SARS-CoV-2 variants such as Omicron represents a global health challenge.
P. Arunachalam, Yupeng Feng, U. Ashraf, Mengyun Hu, A. Walls, V. Edara, V. Zarnitsyna, P. Aye, Nadia A Golden, Marcos C. Miranda, Kristyn W. M. Green, Breanna M. Threeton, N. Maness, B. Beddingfield, R. Bohm, S. Scheuermann, K. Goff, J. Dufour, K. Russell-Lodrigue, Elizabeth Kepl, B. Fiala, Samuel P Wrenn, Rashmi Ravichandran, Daniel Ellis, L. Carter, Kenneth A. Rogers, Lisa M. Shirreff, Douglas E. Ferrell, Nihar R. Deb Adhikary, J. Fontenot, Holly Hammond, M. Frieman, A. Grifoni, A. Sette, D. O’hagan, R. G. van der Most, R. Rappuoli, F. Villinger, H. Kleanthous, J. Rappaport, M. Suthar, D. Veesler, Taia T. Wang, N. King, B. Pulendran   +44 more
semanticscholar   +1 more source

A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin

Nature Communications, 2021
Given the encouraging clinical results of both candidate subunit vaccines and revaccination with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for combining BCG and subunit vaccination for increased efficacy.
J. Woodworth, Helena Strand Clemmensen, Hannah Battey, K. Dijkman, T. Lindenstrøm, R. S. Laureano, R. Taplitz, J. Morgan, C. Aagaard, I. Rosenkrands, C. L. Lindestam Arlehamn, P. Andersen, R. Mortensen   +12 more
semanticscholar   +1 more source

Hydrogel‐Based Slow Release of a Receptor‐Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS‐CoV‐2

Advances in Materials, 2021
The development of effective vaccines that can be rapidly manufactured and distributed worldwide is necessary to mitigate the devastating health and economic impacts of pandemics like COVID‐19.
Emily C. Gale, Abigail E. Powell, Gillie A. Roth, Emily L. Meany, Jerry Yan, Ben S. Ou, Abigail K. Grosskopf, Julia Z. Adamska, Vittoria C. T. M. Picece, Andrea I. d’Aquino, B. Pulendran, Peter S. Kim, Eric A. Appel   +12 more
semanticscholar   +1 more source

Comparison of the Immune Effects of an mRNA Vaccine and a Subunit Vaccine against Herpes Zoster Administered by Different Injection Methods

Vaccines, 2023
Previous studies have shown that the herpes zoster subunit vaccine Shingrix™ performs well in clinical trials. However, the key ingredient in its adjuvant, QS21, is extracted from rare plants in South America, so vaccine production is limited.
Kangyang Lin, Han Cao, Ning Luan, Yunfei Wang, Jingping Hu, Cunbao Liu   +5 more
doaj   +1 more source