Results 21 to 30 of about 1,122,864 (370)

Design of a multi-epitope protein as a subunit vaccine against lumpy skin disease using an immunoinformatics approach

Scientific Reports, 2022
Lumpy skin disease (LSD) is a transboundary viral disease of cattle that causes substantial economic loss globally. There is no specific treatment and subunit vaccine for this disease to date.
P. P. Kar, Prasanna Babu Araveti, Akshay Kuriakose, A. Srivastava   +3 more
semanticscholar   +1 more source

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Nature Communications, 2021
SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies against the viral spike (S).
Hyon-Xhi Tan, J. Juno, W. Lee, Isaac M. Barber-Axthelm, Hannah G. Kelly, K. Wragg, R. Esterbauer, T. Amarasena, F. Mordant, K. Subbarao, S. Kent, A. Wheatley   +11 more
semanticscholar   +1 more source

Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies

Acta Pharmaceutica Sinica B, 2023
Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs.
Yingying Hou, Min Chen, Yuan Bian, Xi Zheng, Rongsheng Tong, Xun Sun   +5 more
doaj   +1 more source

A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine

Science Translational Medicine, 2022
There is currently no licensed vaccine for respiratory syncytial virus (RSV). Here, we assess the effect of RSV fusion protein (F) conformation on B cell responses in a post hoc comparison of samples from the DS-Cav1 [prefusion (pre-F)] and MEDI7510 ...
Lauren A. Chang, Emily Phung, M. Crank, Kaitlyn M. Morabito, T. Villafana, F. Dubovsky, J. Falloon, M. Esser, Bob C. Lin, Grace L. Chen, B. Graham, T. Ruckwardt   +11 more
semanticscholar   +1 more source

Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human

Frontiers in Immunology, 2022
Under the background of the severe human health and world economic burden caused by COVID-19, the attenuation of vaccine protection efficacy, and the prevalence and immune escape of emerging variants of concern (VOCs), the third dose of booster ...
Yuwei Zhang, Mingxiao Yao, Xingyu Guo, Shanshan Han, Shu Zhang, Jinzhong Zhang, Xiangkun Jiang, Jianxing Wang, Ming Fang, Shuang Wang, Bo Pang, Xiaolin Liu, Zengqiang Kou, Xiaolin Jiang, Xiaolin Jiang   +14 more
doaj   +1 more source

Trivalent Subunit Vaccine Candidates for COVID-19 and Their Delivery Devices

Journal of the American Chemical Society, 2021
The COVID-19 pandemic highlights the need for platform technologies enabling rapid development of vaccines for emerging viral diseases. The current vaccines target the SARS-CoV-2 spike (S) protein and thus far have shown tremendous efficacy. However, the
Oscar A. Ortega-Rivera, Matthew D. Shin, Angela Chen, V. Beiss, Miguel A Moreno-Gonzalez, M. A. Lopez‐Ramirez, M. Reynoso, Hong Wang, B. Hurst, Joseph Wang, J. Pokorski, N. Steinmetz   +11 more
semanticscholar   +1 more source

Production of a subunit vaccine candidate against porcine post-weaning diarrhea in high-biomass transplastomic tobacco [PDF]

, 2012
Post-weaning diarrhea (PWD) in piglets is a major problem in piggeries worldwide and results in severe economic losses. Infection with Enterotoxigenic Escherichia coli (ETEC) is the key culprit for the PWD disease.
Cox, Eric, Devriendt, Bert, Joensuu, Jussi, Kaldis, Angelo, Kolotilin, Igor, Menassa, Rima   +5 more
core   +10 more sources

Immunogenicity and protective efficacy of OmpA subunit vaccine against Aeromonas hydrophila infection in Megalobrama amblycephala: An effective alternative to the inactivated vaccine

Frontiers in Immunology, 2023
Aeromonas hydrophila is a kind of zoonotic pathogen, which can cause bacterial septicemia in fish and bring huge economic losses to global aquaculture. Outer membrane proteins (Omps) are conserved antigens of Aeromonas hydrophila, which can be developed ...
Minying Zhang, Ting Zhang, Yang He, Hujun Cui, Hujun Cui, Hong Li, Zehua Xu, Xu Wang, Yunlong Liu, Hongping Li, Xiaoheng Zhao, Xiaoheng Zhao, Hanliang Cheng, Hanliang Cheng, Jianhe Xu, Jianhe Xu, Xiangning Chen, Xiangning Chen, Zhujin Ding, Zhujin Ding   +19 more
doaj   +1 more source

Subunit vaccines for Acinetobacter baumannii

Frontiers in Immunology, 2023
Acinetobacter baumannii is a gram-negative bacterium and a crucial opportunistic pathogen in hospitals. A. baumannii infection has become a challenging problem in clinical practice due to the increasing number of multidrug-resistant strains and their prevalence worldwide. Vaccines are effective tools to prevent and control A. baumannii infection.
Ning Yang, Xiao Jin, Chenghua Zhu, Fenglin Gao, Zheqi Weng, Xingran Du, Ganzhu Feng   +6 more
openaire   +3 more sources

Acute retinal necrosis following recombinant subunit varicella-zoster virus vaccine

American Journal of Ophthalmology Case Reports, 2020
Purpose: Previously, secondary prevention of herpes zoster required live-attenuated vaccination, which is contraindicated in immunocompromised populations.
Rebecca I. Chen, Jordan D. Deaner, Sunil K. Srivastava, Careen Y. Lowder   +3 more
doaj   +1 more source