Results 1 to 10 of about 433,622 (361)

Succinate dehydrogenase‐deficient malignant paraganglioma complicated by succinate dehydrogenase‐deficient renal cell carcinoma [PDF]

IJU Case Reports, 2022
Introduction SDH Gene mutation is known to be a common cause of pheochromocytoma/paraganglioma and renal cell carcinoma. Here, we report a case of succinate dehydrogenase B‐deficient paraganglioma, which has a high risk of metastasis and recurrence ...
Yoshitomo Yamaguchi, Minato Yokoyama, Akira Takemoto, Yuki Nakamura, Shohei Fukuda, Sho Uehara, Hajime Tanaka, Soichiro Yoshida, Yoh Matsuoka, Yasuhisa Fujii   +9 more
doaj   +4 more sources

Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis

Redox Biology, 2021
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically compromising lung function and death. However, very little is known about
Ziwen Wang, Long Chen, Yu Huang, Min Luo, Huilan Wang, Zhongyong Jiang, Jiancheng Zheng, Zeyu Yang, Zelin Chen, Chi Zhang, Lei Long, Yawei Wang, Xueru Li, Fengying Liao, Yibo Gan, Peng Luo, Yunsheng Liu, Yu Wang, XuTan, Ziyuan Zhou, Aihua Zhang, Chunmeng Shi   +21 more
doaj   +2 more sources

Inhibition of Succinate Dehydrogenase by Pesticides (SDHIs) and Energy Metabolism [PDF]

Int J Mol Sci, 2023
Succinate dehydrogenase (SDH) is one of the enzymes of the tricarboxylic acid cycle (Krebs cycle) and complex II of the mitochondrial respiratory chain. A class of fungicides (SDHIs) targets the complex II reaction in the SDH.
F. Bouillaud
semanticscholar   +2 more sources

Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

Biomedicines, 2022
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism.
Paule Bénit, Judith Goncalves, Riyad El Khoury, Malgorzata Rak, Judith Favier, Anne-Paule Gimenez-Roqueplo, Pierre Rustin   +6 more
doaj   +2 more sources

Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/-galactosamine-induced acute hepatic damage in mice

Innate Immunity, 2019
In addition to its energy-supplying function, increasing evidence suggests that mitochondria also play crucial roles in the regulation of inflammation.
Yongqiang Yang, Ruyue Shao, Li Tang, Longjiang Li, Min Zhu, Jiayi Huang, Yi Shen, Li Zhang   +7 more
doaj   +2 more sources

Imaging findings of succinate dehydrogenase‐deficient renal cell carcinoma [PDF]

Clinical Case Reports, 2023
Key Clinical Message A 50‐year‐old man with a mass located in the left kidney was described by multimodal images, including ultrasonography, computed tomography, and magnetic resonance imaging.
Wenqin Liu, Guiwu Chen, Jiaxin Meng, Xiaomin Liao, Yuhuan Xie   +4 more
doaj   +2 more sources

Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid cell factory. [PDF]

PLoS ONE, 2013
Saccharomyces cerevisiae is the most well characterized eukaryote, the preferred microbial cell factory for the largest industrial biotechnology product (bioethanol), and a robust commerically compatible scaffold to be exploitted for diverse chemical ...
José Manuel Otero, Donatella Cimini, Kiran R Patil, Simon G Poulsen, Lisbeth Olsson, Jens Nielsen   +5 more
doaj   +6 more sources

Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation [PDF]

Nature Communications
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on ...
Yifan Chen, Miao Xian, Wenwen Ying, Jiayi Liu, Shaowei Bing, Xiaomin Wang, Jiayi Yu, Xiaojun Xu, Senfeng Xiang, Xuejing Shao, Ji Cao, Qiaojun He, Bo Yang, Meidan Ying   +13 more
doaj   +2 more sources

Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase [PDF]

Nat Metab
Shane M O'Carroll, Christian G. Peace, J. Toller-Kawahisa, Yukun Min, Alexander Hooftman, Sara Charki, Louise Kehoe, Maureen J O'Sullivan, Aline Zoller, A. F. Mcgettrick, Alessia Zotta, E. Day, Maria Simarro, Neali Armstrong, Justin P. Annes, L. O'Neill   +15 more
semanticscholar   +2 more sources

Succinate and succinate dehydrogenase as a «foothold» in the Krebs cycle in critical conditions

Антибиотики и Химиотерапия, 2023
Purpose. Search and presentation of data from experimental and clinical studies reflecting the central role of succinate and succinate dehydrogenase in the regulation of adaptation mechanisms in critical conditions. Material and methods.
Yu. P. Orlov, A. V. Butrov, S. V. Sviridov, V. V. Afanasiev, A. N. Kondratiev, L. M. Tsentsiper, N. V. Govorova, A. I. Kondratiev, G. A. Baytugaeva, E. N. Kakulya   +9 more
doaj   +1 more source