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Inhibition of Succinate Dehydrogenase by Pesticides (SDHIs) and Energy Metabolism. [PDF]
Int J Mol Sci, 2023 Succinate dehydrogenase (SDH) is one of the enzymes of the tricarboxylic acid cycle (Krebs cycle) and complex II of the mitochondrial respiratory chain. A class of fungicides (SDHIs) targets the complex II reaction in the SDH.
Bouillaud F.
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Redox Biology, 2021 Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically compromising lung function and death. However, very little is known about
Ziwen Wang +21 more
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Succinate dehydrogenase‐deficient malignant paraganglioma complicated by succinate dehydrogenase‐deficient renal cell carcinoma [PDF]
IJU Case Reports, 2022 Introduction SDH Gene mutation is known to be a common cause of pheochromocytoma/paraganglioma and renal cell carcinoma. Here, we report a case of succinate dehydrogenase B‐deficient paraganglioma, which has a high risk of metastasis and recurrence ...
Yoshitomo Yamaguchi +9 more
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Studies on Succinate Dehydrogenase. 8alpha-Histidyl-FAD as the Active Center of Succinate Dehydrogenase [PDF]
European Journal of Biochemistry, 1972 1. Succinate dehydrogenase flavocoenzyme (“SD-flavin”), previously shown to be an SOLsubstituted riboflavin derivative containing a tertiary nitrogen homoconjugated to the flavin nucleus, was subjected to further hydrolysis and to reduction under acid conditions. Both conditions resulted in the liberation of 1 mole of histidine per mole of flavin. This
Wolfram H. Walker +3 more
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Biomedicines, 2022 Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism.
Paule Bénit +6 more
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Reversible activation of succinate dehydrogenase [PDF]
Biochemical Journal, 1969 1. Treatment of particulate respiratory chain preparations in ways expected to raise or lower the concentration of endogenous soluble low-molecular-weight compounds respectively increased and diminished the capacity of succinate dehydrogenase to become activated reversibly and ‘spontaneously’ when preparations were diluted in tris acetate buffer and ...
R.G. McDonald-Gibson, M. B. Thorn
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Imaging findings of succinate dehydrogenase‐deficient renal cell carcinoma [PDF]
Clinical Case Reports, 2023 Key Clinical Message A 50‐year‐old man with a mass located in the left kidney was described by multimodal images, including ultrasonography, computed tomography, and magnetic resonance imaging.
Wenqin Liu +4 more
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Innate Immunity, 2019 In addition to its energy-supplying function, increasing evidence suggests that mitochondria also play crucial roles in the regulation of inflammation.
Yongqiang Yang +7 more
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Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation [PDF]
Nature CommunicationsDrug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on ...
Yifan Chen +13 more
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Succinate and succinate dehydrogenase as a «foothold» in the Krebs cycle in critical conditions
Антибиотики и Химиотерапия, 2023 Purpose. Search and presentation of data from experimental and clinical studies reflecting the central role of succinate and succinate dehydrogenase in the regulation of adaptation mechanisms in critical conditions. Material and methods.
Yu. P. Orlov +9 more
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