Results 61 to 70 of about 433,622 (361)
Succinate Dehydrogenase-Deficient Renal Cell Carcinoma
Definitions, 2020 A very rare renal cell carcinoma that usually affects young adults. It is characterized by the presence of vacuolated, eosinophilic to clear neoplastic cells and loss of immunohistochemical expression of succinate dehydrogenase (SDH) B.
A. Caliò, D. Segala, G. Martignoni
semanticscholar +1 more source
PLoS ONE, 2019 Mitochondrial disorders arise from defects in nuclear genes encoding enzymes of oxidative metabolism. Mutations of metabolic enzymes in somatic tissues can cause cancers due to oncometabolite accumulation. Paraganglioma and pheochromocytoma are examples,
Megan M Braun +5 more
doaj +1 more source
Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors
World Journal of Gastroenterology, 2020 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. At the molecular level, GISTs can be categorized into two groups based on the causative oncogenic mutations.
Yue Zhao +4 more
semanticscholar +1 more source
Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]
, 2019 York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core +1 more source
Reversible activation of succinate dehydrogenase [PDF]
Biochemical Journal, 1969 1. Treatment of particulate respiratory chain preparations in ways expected to raise or lower the concentration of endogenous soluble low-molecular-weight compounds respectively increased and diminished the capacity of succinate dehydrogenase to become activated reversibly and ‘spontaneously’ when preparations were diluted in tris acetate buffer and ...
R G, McDonald-Gibson, M B, Thorn
openaire +2 more sources
Phytomedicine Plus, 2022 Background: Betulinic acid, a naturally occurring pentacyclic triterpenoid is found in a variety of plants. A range of biological properties including anticancer activity has been reported for betulinic acid.
Anamika Bhaumik +2 more
doaj +1 more source
Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics
International Journal of Endocrinology, 2015 It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in
Yeng F. Her, L. James Maher
doaj +1 more source
Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH. [PDF]
, 2020 The microbial adaptations to the respiratory burst remain poorly understood, and establishing how the NADPH oxidase (NOX2) kills microbes has proven elusive. Here we demonstrate that NOX2 collapses the ΔpH of intracellular Salmonella Typhimurium.
Chakraborty, Sangeeta +7 more
core
Growth of Rhodococcus sp. strain BCP1 on gaseous n-alkanes: New metabolic insights and transcriptional analysis of two soluble di-iron monooxygenase genes [PDF]
, 2015 Rhodococcus sp. strain BCP1 was initially isolated for its ability to grow on gaseous n-alkanes, which act as inducers for the co-metabolic degradation of low-chlorinated compounds.
Cappelletti M. +6 more
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source