Results 101 to 110 of about 3,361 (281)

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

open access: yesAdvanced Science, EarlyView.
MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao   +7 more
wiley   +1 more source

Research of nitrogen-excretory function of kidneys in immature rats against the background of administration of new urolithic agent based on succinate under the conditions of experimental simulation of renal failure

open access: yesZaporožskij Medicinskij Žurnal, 2013
Presented results of the study of complex (Sc+PE) influence on the nitrogen-excretory kidney function at the conditions of experimental kidney insufficiency in young rats showed, that application of mentioned complex in 2,0 ml/kg dose produces more ...
T. I. Ermolenko   +2 more
doaj   +1 more source

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

open access: yesAdvanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou   +5 more
wiley   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

open access: yesAdvanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu   +10 more
wiley   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

open access: yesAdvanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu   +4 more
wiley   +1 more source

Polymer Distribution and Mechanism Conversion in Multiple Media of Phase-Separated Controlled-Release Film-Coating

open access: yesPharmaceutics, 2019
Phase-separated films of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC) can be utilized to tailor drug release from coated pellets. In the present study, the effects of HPC levels and the pH, type, ionic strength and
Lu Chen   +9 more
doaj   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

open access: yesAdvanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang   +15 more
wiley   +1 more source

The Audio Frequency Conductance Study of Some Metal Succinate Salts in Aqueous Medium at Different Temperatures (Part Ii: Zinc, Nickel and Cobalt Succinates)

open access: yesScience Journal of University of Zakho, 2013
The electrical conductances of aqueous solutions of zinc, nickel and cobalt succinates have been measured at four temperatures in the temperature range from 298.15K to 313.15K.
Kosrat N. Kaka   +2 more
doaj  

Hypromellose Acetate Succinates as a Single Mebeverine Hydrochloride Release-Modifying Excipient for Fused Deposition Modeling

open access: yesApplied Sciences
Background: Three-dimensional (3D) printing has been established in pharmaceutical sciences for preparing customized dosage forms with intricate release profiles. However, realizing this potential requires complex design strategies and the careful use of
Mateusz Kurek   +5 more
doaj   +1 more source

Influence of cadmium salts on the development of the skeletal system and in the correction with succinates of metals (literature review) [PDF]

open access: yes, 2021
Environmental contamination is becoming an increasingly serious problem for humanity every year. One of the most dangerous, long-acting and stable pollutants are heavy metals, the most common man-made associations of which are represented by salts of ...
Kosse, Valentin   +2 more
core  

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