Results 111 to 120 of about 3,361 (281)

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

open access: yesAdvanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu   +16 more
wiley   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen   +12 more
wiley   +1 more source

Gut Microbe‐Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

open access: yesAdvanced Science, EarlyView.
Acinetobacter regulates dinotefuran tolerance in Propylea japonica by mediating the expression of the horizontally transferred gene PjDUF1. Abstract Insect–microbial symbiont relationships are widespread in nature and often involve lateral gene transfer.
Ningbo HuangFu   +10 more
wiley   +1 more source

Combining Electrochemical Reduction with Biosynthesis for Directed Conversion of CO2 into a Library of C3 Chemicals

open access: yesAdvanced Science, EarlyView.
In the H‐type electrolytic cell, carbon dioxide is reduced to acetic acid via electro‐microbial catalysis. The simply processed acetic acid is further converted through biological fermentation into high‐value‐added products, including acrylic acid, L‐lactic acid, and β‐alanine.
Kaixing Xiao   +8 more
wiley   +1 more source

Conformation‐Modulated Lignin for Durable and High‐Output Cellulosic Triboelectric Materials Toward Self‐Powered Sensing

open access: yesAdvanced Science, EarlyView.
Conformation‐engineered alkali lignin with flexible aliphatic side chains is integrated into cellulose to suppress tribo‐induced fiber fibrillation and interfacial wear. Dynamic chain adaptability enhances frictional energy dissipation and dielectric polarization, enabling durable, high‐output triboelectric sensing with excellent recyclability and ...
Lujie Wang   +11 more
wiley   +1 more source

Enhanced Energy Harvesting Performance of Biodegradable Polylactic Acid/3D Anodic Aluminum Oxide Composite Triboelectric Nanogenerators

open access: yesAdvanced Electronic Materials, EarlyView.
Polylactic acid (PLA) embedded in 3D anodic aluminum oxide (3D‐AAO) yields triboelectric nanogenerators (TENGs) with ɛeff = 5.1, delivering 20V and 108µW both per cm2. These agglomeration‐resistant, compostable/biocompatible devices retain 95% output after 104 cycles, enabling robust self‐powered Internet of Things (IoT) sensing.
Carlos G. Cobos   +5 more
wiley   +1 more source

Mobocertinib Succinate

open access: yesAmerican Journal of Health-System Pharmacy, 2021
openaire   +2 more sources

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen   +12 more
wiley   +1 more source

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy