Results 101 to 110 of about 7,622 (205)

Large-Scale Assessment of Bioinformatics Tools for Lysine Succinylation Sites

open access: yesCells, 2019
Lysine succinylation is a form of posttranslational modification of the proteins that play an essential functional role in every aspect of cell metabolism in both prokaryotes and eukaryotes.
Md. Mehedi Hasan   +2 more
doaj   +1 more source

Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells [PDF]

open access: yes, 2012
Cisplatin is one of the most widely used anticancer drugs. Its side effects, however, have motivated researchers to search for equally effective analogs that are better tolerated. Selectively targeting cancer tissue is one promising strategy.
Graf, Nora   +3 more
core   +1 more source

Structure–activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists [PDF]

open access: yes, 2015
Neurokinin B (NKB) regulates the secretion of gonadotropin-releasing hormone (GnRH) in the hypothalamus via activation of the cognate neurokinin-3 receptor (NK3R).
Fujii, Nobutaka   +10 more
core   +1 more source

Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism

open access: yesiScience, 2018
Summary: Succinylation is a post-translational protein acylation modification that converts the cationic lysine side chain to an anion with large potential impacts on protein structure and function. Here we characterize the epigenome-wide distribution of
John Smestad   +3 more
doaj   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

open access: yes, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA   +4 more
core   +1 more source

HAMAP in 2015: updates to the protein family classification and annotation system. [PDF]

open access: yes, 2015
HAMAP (High-quality Automated and Manual Annotation of Proteins-available at http://hamap.expasy.org/) is a system for the automatic classification and annotation of protein sequences. HAMAP provides annotation of the same quality and detail as UniProtKB/
Auchincloss, A.H.   +12 more
core   +1 more source

Modifikasi Protein Dedak Jagung dengan Gum Xanthan untuk Pengembangan Sifat Fungsional Menggunakan Ion Kalsium [PDF]

open access: yes, 2010
Interaksi protein dedak jagung dan gum xanthan bertujuan untuk memperbaiki sifat fungsional sehingga dapat diaplikasikan dalam berbagai produk pangan.Metode penelitian meliputi tahapan pencucian lemak, pemisahan isolat dengan teknik pelarutan pada pH 8,5
Sudiyono, S. (Sudiyono)   +1 more
core  

Succinyl Choline

open access: yesنشریه پرستاری ایران, 1998
This is an associational research which was conducted to evaluate the correlation between plasma level of pseudocholinesterase and duration of succinylcholine induced apnea in patients undergoing general anesthesia in one of the hospitals of Iran medical Sciences University in 1993.
openaire   +1 more source

Succinylation Links Metabolism to Protein Functions

open access: yesNeurochemical Research, 2019
Post-translational modifications (PTMs) are important regulators of protein function, and integrate metabolism with physiological and pathological processes. Phosphorylation and acetylation are particularly well studied PTMs. A relatively recently discovered novel PTM is succinylation in which metabolically derived succinyl CoA modifies protein lysine ...
Yun Yang, Gary E. Gibson
openaire   +3 more sources

SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1

open access: yesGynecological Endocrinology
Polycystic ovarian syndrome (PCOS) is a major cause of infertility. Succinylation is involved in disease processes; however, its role in PCOS remains unknown.
Yiwen Zhang   +6 more
doaj   +1 more source

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