Results 81 to 90 of about 7,622 (205)

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. [PDF]

, 2018
Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
A Cleasby, A Dhar, A Kobayashi, A Moraru, A Shevchenko, A Uruno, AC Ruifrok, Arnab K. Chatterjee, BR Sabari, BT Weinert, CL Saw, Claudio Zambaldo, D Martinez Molina, DD Zhang, Emily N. Chin, FW Chaplen, Gihoon Lee, GP Sykiotis, GR Wagner, H Lin, Hwayoung Yun, Insha Ahmad, Jae Won Chang, John S. Coukos, JW Chang, Luke L. Lairson, M Ravichandran, MC Jaramillo, Michael J. Bollong, N Rabbani, N Rabbani, N Wakabayashi, Peter G. Schultz, Raymond E. Moellering, RE Moellering, RH Scannevin, S Nishimoto, S Tao, SC Lo, T Bücher, T Ogura, TB El-Abaseri, TO Khor, TW Lo, W Hur, W Hur, Y Mitsuishi, Z Zhang   +47 more
core   +2 more sources

Understanding protein–flavor interactions: Factors, characterization techniques, and the effect of processing

Food Biomacromolecules, Volume 3, Issue 1, Page 47-70, March 2026.
Abstract The perception of flavor in a food system depends on its release from the protein matrix. Apart from hydrogen bonding, hydrophobic interactions and van der Waal's forces, the formation of covalent adducts between the flavor and protein highly impacts the release of flavor from the protein matrix.
Arshita Verma, Somnath Basak, Rekha S. Singhal   +2 more
wiley   +1 more source

Tartryl-CoA inhibits succinyl-CoA synthetase

Acta Crystallographica Section F Structural Biology Communications, 2020
Succinyl-CoA synthetase (SCS) catalyzes the only substrate-level phosphorylation step in the tricarboxylic acid cycle. Human GTP-specific SCS (GTPSCS), an αβ-heterodimer, was produced inEscherichia coli. The purified protein crystallized from a solution containing tartrate, CoA and magnesium chloride, and a crystal diffracted to 1.52 Å resolution ...
Ji Huang, Marie E. Fraser
openaire   +3 more sources

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Conformational destabilization of Bacillus licheniformis α-amylase induced by lysine modification and calcium depletion [PDF]

, 2011
Bacillus licheniformis α-amylase (BLA) was chemically modified using 100-fold molar excess of succinic anhydride over protein or 0.66 M potassium cyanate to obtain 42 % succinylated and 81 % carbamylated BLAs.
Abdul Kadir, Habsah, Raja Abdul Rahman, Raja Noor Zaliha, Tan, Cheau Yuaan, Tayyab, Saad   +3 more
core  

Sintesis dan sifat termal natrium kanji sulfat Dioscorea pentaphylla [PDF]

, 2017
Kanji Dioscorea pentaphylla telah diubah suai dengan pensulfatan dan peneutralan bagi menghasilkan natrium kanji sulfat. Tindak balas pensulfatan dilakukan dengan asid sulfurik dalam etanol dan air pada suhu 0oC.
Azwan Mat Lazim,, M.S. Elmi Sharlina,, Wan Yaacob Wan Ahmad,   +2 more
core   +1 more source

Recent Developments and Applications of Capillary and Microchip Electrophoresis in Proteomics and Peptidomics (2023–2025)

Journal of Separation Science, Volume 49, Issue 3, March 2026.
ABSTRACT This review article presents a broad overview of developments and applications of capillary electrophoresis (CE) and microchip electrophoresis (MCE) in peptidomics and proteomics in the period 2023–2025. It deals with various methodological aspects, such as sample preparation including preseparation and preconcentration, multidimensional ...
Sille Štěpánová, Václav Kašička
wiley   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Detecting Succinylation sites from protein sequences using ensemble support vector machine

BMC Bioinformatics, 2018
Background Lysine succinylation is a new kind of post-translational modification which plays a key role in protein conformation regulation and cellular function control. To understand the mechanism of succinylation profoundly, it is necessary to identify
Qiao Ning, Xiaosa Zhao, Lingling Bao, Zhiqiang Ma, Xiaowei Zhao   +4 more
doaj   +1 more source

Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer

Journal of Experimental & Clinical Cancer Research, 2020
Background Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored.
Xiang Li, Chen Zhang, Ting Zhao, Zhongping Su, Mengjing Li, Jiancheng Hu, Jianfei Wen, Jiajia Shen, Chao Wang, Jinshun Pan, Xianmin Mu, Tao Ling, Yingchang Li, Hao Wen, Xiaoren Zhang, Qiang You   +15 more
doaj   +1 more source