Succinate metabolism: a new therapeutic target for myocardial reperfusion injury. [PDF]
, 2016 Myocardial ischaemia/reperfusion (IR) injury is a major cause of death worldwide and remains a disease for which current clinical therapies are strikingly deficient. While the production of mitochondrial reactive oxygen species (ROS) is a critical driver
Chouchani, Edward T +4 more
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Sirtuins in Kidney Injury and Disease [PDF]
, 2020 Acute kidney injury (AKI) is an extremely common medical affliction resulting from hypoxic, nephrotoxic and septic insults affecting approximately 20% of all hospital patients and up to 50% of patients in the intensive care unit.
Peasley, Kevin
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Posttranslational Modifications in Mitochondria: Protein Signaling in the Powerhouse [PDF]
, 2016 There is an intimate interplay between cellular metabolism and the pathophysiology of disease. Mitochondria are essential to maintaining and regulating metabolic function of cells and organs.
Payne, R. Mark, Stram, Amanda R.
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Succinilação e malonilação de proteínas na esquizofrenia [PDF]
, 2020 Orientador: Daniel Martins de SouzaDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de BiologiaResumo: A esquizofrenia é uma doença mental multifatorial que afeta até 1% da população mundial.
Smith, Bradley Joseph, 1994-
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SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease [PDF]
, 2020 Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a mitochondrial encephalomyopathy of unknown pathomechanism.
Alkhater, Reem A. +25 more
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Oncology Reports, 2020 Abnormal protein acetylation and succinylation in lysine residues can cause the initiation and development of numerous different types of tumors. However, to the best of our knowledge, there is currently a lack of systematic investigation in breast cancer.
Xiuli Gao +5 more
openaire +3 more sources
Blubber Transciptome Response to Acute Stress Axis Activation Involves Transient Charges in Adipogenesis and Lipolysis in Fast-Adapted Marine Mammal [PDF]
, 2017 Stress can compromise an animal\u27s ability to conserve metabolic stores and participate in energy-demanding activities that are critical for fitness.
Champagne, C. D. +3 more
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Journal of the Endocrine Society, 2019 Hypothyroidism is a common disease, and its molecular mechanism still needs further investigation. Succinylation, as a newly identified protein posttranslational modification, is found to be involved in various metabolisms and cellular processes. In the present study, we performed quantitative analysis of the lysine succinylome in the thyroid of rats ...
Hu, Baoxiang +9 more
openaire +1 more source
Cardiovascular proteomics in the era of big data: experimental and computational advances. [PDF]
, 2016 Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past decade, proteomics applications can now go beyond merely inventorying protein species, and ...
Lam, Maggie +4 more
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The impact of Type 1 Diabetes on skeletal muscle fuel substrate storage and ultrastructure in rodents and adult humans [PDF]
, 2021 Type 1 diabetes (T1D) is the result of the autoimmune-mediated destruction of the pancreatic beta-cells leading to the inability to produce insulin sufficiently and, in turn, regulate blood glucose levels.
Nguyen, Maria
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