Results 71 to 80 of about 423 (139)

Glycolanguage of the oral microbiota

Molecular Oral Microbiology, Volume 39, Issue 5, Page 291-320, October 2024.
Oral bacteria speak a sophisticated glycolanguage transmitted through versatile glycoinfrastructure, carbohydrate‐active enzymes, and lectins, which contributes decisively to their success in the oral habitat. Deciphering this glycolanguage opens new avenues for novel antibacterials to treat oral diseases. Abstract The oral cavity harbors a diverse and
Fiona F. Hager‐Mair, Susanne Bloch, Christina Schäffer   +2 more
wiley   +1 more source

SIRT5‐Mediated Desuccinylation of RAB7A Protects Against Cadmium‐Induced Alzheimer's Disease‐Like Pathology by Restoring Autophagic Flux

Advanced Science, Volume 11, Issue 30, August 14, 2024.
The underlying mechanism of autophagy on environmental cadmium‐induced Alzheimer's disease progression is vague. The findings indicated that SIRT5 desuccinylated and activated RAB7A at the K31 residue to rescue the cadmium‐provoked Alzheimer's disease progression by restoring the autophagic flux, and identified potential targets for the treatment of ...
Ping Deng, Tengfei Fan, Peng Gao, Yongchun Peng, Min Li, Jingdian Li, Mingke Qin, Rongrong Hao, Liting Wang, Min Li, Lei Zhang, Chunhai Chen, Mindi He, Yonghui Lu, Qinlong Ma, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Shangcheng Xu, Zhou Zhou, Zhengping Yu, Huifeng Pi   +22 more
wiley   +1 more source

SIRT5 Potentiates Hepatocarcinogenesis by Modulating Protein Acylation in Mice

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveHepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. The main risk factors associated with HCC include viral hepatitis (B and/or C), alcohol abuse, and metabolic dysfunction-associated steatotic liver disease (MASLD ...
ZHANG Yu, REN Feng-Rui, LI Jia-Yun, CHEN Xiang-Yu, WANG Zi-Yi, SUN Qi, ZHAO Jun-Cheng, ZHANG Ye, HUANG Zhen, HU Hao, WEI Tao-Tao, XIAO Min   +11 more
doaj   +1 more source

Lysine succinylation precisely controls normal erythropoiesis

Haematologica
Lysine succinylation (Ksu) has recently emerged as a protein modification that regulates diverse functions in various biological processes. However, the systemically and precise role of lysine succinylation in erythropoiesis remains to be fully ...
Bin Hu, Han Gong, Ling Nie, Ji Zhang, Yanan Li, Dandan Liu, Huifang Zhang, Haihang Zhang, Lu Han, Chaoying Yang, Maohua Li, Wenwen Xu, Yukio Nakamura, Lihong Shi, Mao Ye, Christopher D. Hillyer, Narla Mohandas, Long Liang, Yue Sheng, Jing Liu   +19 more
doaj   +1 more source

ScCobB2-mediated Lysine Desuccinylation Regulates Protein Biosynthesis and Carbon Metabolism in Streptomyces coelicolor

, 2019
As a recently discovered protein posttranslational modification in eukaryotes, lysine succinylation has attracted increasing interest due to its ability to regulate several critical cellular processes, including catabolism, β-oxidation, and ketogenesis ...
Hong Zhang (17684142)
core   +1 more source

Characterization of lysine succinylome in tomato.

, 2016
Enrichment analysis of succinylated proteins according to the classification of GO annotation, which is based on biological processes (gray bars) (p < 0.05) and molecular function (black bars) (A) and KEGG pathway enrichment analysis (p < 0.05) (B).
Fangli Wu (516340), Weibo Jin (14025)
core   +1 more source

Systematic analysis of lysine acetylome and succinylome reveals the correlation between modification of H2A.X complexes and DNA damage response in breast cancer

Oncology Reports, 2020
Abnormal protein acetylation and succinylation in lysine residues can cause the initiation and development of numerous different types of tumors. However, to the best of our knowledge, there is currently a lack of systematic investigation in breast cancer.
Xiuli Gao, Hongguang Bao, Likun Liu, Wenbin Zhu, Liping Zhang, Liling Yue   +5 more
openaire   +3 more sources

The acetylome and succinylome of B. subtilis profiled in this study.

, 2015
(A) Functional classification of the identified acetylated proteins (629) and succinylated proteins (204) based on the KEGG pathway database. Red and blue bars represent the number of acetylated and succinylated proteins, respectively.
Makoto Nishiyama (758947), Masaru Tamura (758945), Yumi Kawamura (566671), Saori Kosono (758944), Minoru Yoshida (151970), Ayako Yoshida (296840), Shota Suzuki (758946)   +6 more
core   +1 more source

Phytoplasma-induced Changes in the Acetylome and Succinylome of Paulownia tomentosa Provide Evidence for Involvement of Acetylated Proteins in Witches' Broom Disease

Molecular & Cellular Proteomics, 2019
Lysine acetylation and succinylation are post-translational modifications of proteins that have been shown to play roles in plants response to pathogen infection. Phytoplasma infection can directly alter multiple metabolic processes in the deciduous plant Paulownia and lead to Paulownia witches' broom (PaWB) disease, the major cause of Paulownia ...
Yabing Cao, Guoqiang Fan, Zhe Wang, Zhibin Gu   +3 more
openaire   +2 more sources

Integrated Succinylome and Metabolome Profiling Reveals Crucial Role of S-Ribosylhomocysteine Lyase in Quorum Sensing and Metabolism of Aeromonas hydrophila*

Molecular & Cellular Proteomics, 2019
Protein modification by lysine succinylation is a newly identified post-translational modification (PTM) of lysine residues and plays an important role in diverse physiological functions, although their associated biological characteristics are still largely unknown.
Zujie Yao, Zhuang Guo, Yuqian Wang, Wanxin Li, Yuying Fu, Yuexu Lin, Wenxiong Lin, Xiangmin Lin   +7 more
openaire   +2 more sources