Results 61 to 70 of about 423 (139)
Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis
Advanced Science, Volume 13, Issue 43, 3 August 2026.Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing +9 more
wiley +1 more source
Arthritis &Rheumatology, Volume 77, Issue 9, Page 1216-1227, September 2025.Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu +11 more
wiley +1 more source
BMC Genomics, 2017 Background Lysine succinylation is a ubiquitous and important protein post-translational modification in various eukaryotic and prokaryotic cells. However, its functions in Dendrobium officinale, an important traditional Chinese orchid herb with high ...
Shangguo Feng +6 more
doaj +1 more source
Posttranslational regulation of plant membrane transporters
The Plant Journal, Volume 121, Issue 3, February 2025.SUMMARY The movement of substances across biological membranes is often constrained by physical or energetic barriers, requiring the action of transporter proteins embedded within the lipidic bilayer. These transporters also provide finely tuned regulation of substrate fluxes, essential for maintaining cellular function under both normal and stress ...
María Niño‐González, Paula Duque
wiley +1 more source
The FEBS Journal, Volume 292, Issue 1, Page 28-46, January 2025.Mass spectrometry (MS)‐based proteomics has proven to be a powerful method capable of mapping, localizing and quantifying post‐translational modifications (PTMs). PTMs play regulatory roles in protein functions/activities and the recognition of PTMs specific to cardiovascular pathologies is crucial for usage in clinics.
Miroslava Stastna
wiley +1 more source
BMC Plant Biology, 2019 Background Chinese hickory (Carya cathayensis) is a popular nut plant having high economic value. Grafting is applied to accelerate the transition from vegetative phase to reproductive phase.
Huwei Yuan +8 more
doaj +1 more source
Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies
MedComm, Volume 5, Issue 10, October 2024.Posttranslational modifications of proteins are involved in the development of metabolism‐related diseases such as diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease. PTMs mediates the development of diabetes mellitus by affecting insulin homeostasis, glucose metabolism, diabetic complications, gluconeogenesis, and β‐cell ...
Yunuo Yang +4 more
wiley +1 more source
Lysine succinylome analysis of MRSA reveals critical roles in energy metabolism and virulence
Letters in Applied MicrobiologyAbstract Methicillin-resistant Staphylococcus aureus’s (MRSA) resistance poses a global health challenge. This study investigates lysine succinylation in MRSA using proteomics and bioinformatics approaches to uncover metabolic and virulence mechanisms, with the goal of identifying novel therapeutic targets.
Xiangqin, Zhu +3 more
openaire +2 more sources
Systematic Analysis of the Lysine Succinylome in Candida albicans
, 2016 Candida albicans is the most common human fungal pathogen for both immunocompetent and immunocompromised individuals. Lysine succinylation is a frequently occurring post-translational modification that is found in many organisms; however, the role of ...
Xiaowei Zhou +9 more
core +2 more sources