Results 41 to 50 of about 423 (139)

Proteome, Lysine Acetylome, and Succinylome Identify Posttranslational Modification of STAT1 as a Novel Drug Target in Silicosis. [PDF]

Mol Cell Proteomics
يؤدي استنشاق غبار السيليكا البلوري إلى تلف الرئة غير القابل للشفاء والسحار السيليسي والتليف الرئوي. ومع ذلك، لا تزال آليات إصابة الرئة غير مفهومة بشكل جيد، مع خيارات علاجية محدودة بصرف النظر عن زراعة الرئة. يمكن أن تنظم تعديلات ما بعد الترجمة وظيفة البروتينات وتلعب دورًا مهمًا في دراسة آليات المرض.
Zhang T, Wang Y, Sun Y, Song M, Pang J, Wang M, Zhang Z, Yang P, Chen Y, Qi X, Zhou H, Han Z, Xing Y, Liu Y, Li B, Liu J, Yang J, Wang J.   +17 more
europepmc   +3 more sources

Heat Shock Strengthens the Protective Potential of MSCs in Liver Injury by Promoting EV Release Through Upregulated Autophagosome Formation. [PDF]

J Extracell Vesicles
ABSTRACT Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) show powerful potential in the treatment of multiple diseases. However, the low yield of MSC‐EVs severely restricts their clinical application. Here, heat shock (HS), a moderate external stimulus, can enhance EVs release of MSCs by upregulating autophagosome formation ...
Wang T, Gong Y, Lin H, Li X, Liang J, Yuan X, Li C, Hu Z, Chen H, Xiao J, Zhang J, Liu Y, Yan X, Jiang C, Yao J, Zhang Q, Li R, Zheng J.   +17 more
europepmc   +2 more sources

Multi‐omic analyses and network biology in cardiovascular disease

PROTEOMICS, Volume 23, Issue 21-22, November 2023., 2023
Abstract Heart disease remains a leading cause of death in North America and worldwide. Despite advances in therapies, the chronic nature of cardiovascular diseases ultimately results in frequent hospitalizations and steady rates of mortality. Systems biology approaches have provided a new frontier toward unraveling the underlying mechanisms of cell ...
Cristine J. Reitz, Uros Kuzmanov, Anthony O. Gramolini   +2 more
wiley   +1 more source

Global profiling of lysine succinylation in human lungs

PROTEOMICS, Volume 22, Issue 17, September 2022., 2022
Abstract The lysine succinylation (Ksucc) is involved in many core energy metabolism pathways and affects the metabolic process in mitochondria, making this modification highly valuable for studying diseases related to mitochondrial disorders. In this paper, we used liquid chromatography with tandem mass spectrometry (LC‐MS/MS) to perform the first ...
Ye‐Hong Yang, Song‐Feng Wu, Yun‐Ping Zhu, Jun‐Tao Yang, Jiang‐Feng Liu   +4 more
wiley   +1 more source

Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review

Environmental Microbiology, Volume 24, Issue 7, Page 2857-2881, July 2022., 2022
Summary Post‐translational modifications (PTMs) are important for protein function and regulate multiple cellular processes and secondary metabolites (SMs) in fungi. Aspergillus species belong to a genus renown for an abundance of bioactive secondary metabolites, many important as toxins, pharmaceuticals and in industrial production. The genes required
Kunlong Yang, Jun Tian, Nancy P. Keller
wiley   +1 more source

Additional file 2 of Proteome-wide analyses reveal diverse functions of protein acetylation and succinylation modifications in fast growing stolons of bermudagrass (Cynodon dactylon L.)

, 2022
Additional file 2: Figure S2: Statistics of the matched spectra in acetylome and succinylome profiling data. Distribution of identified peptides according to the peptide length (A, B), precursor ion tolerance (C, D), unique peptide number (E, F) and ...
Bing Zhang (129), Qixue Sun (14015845), Jianxiu Liu (463587), Zhuoting Chen (14015842)   +3 more
core   +1 more source

Oxidative stress‐triggered interactions between the succinyl‐ and acetyl‐proteomes of rice leaves [PDF]

, 2018
Protein lysine acylations, such as succinylation and acetylation, are important post‐translational modification (PTM) mechanisms, with key roles in cellular regulation.
Guan, W, Messens, J, Bo Wei, Wei, B, Huang, Jingjing, Iris Finkemeier, Shen, Wenbiao, Michael H. Wilson, Xie, Yanjie, Zhou, Heng, Finkemeier, Iris, Zhu, J, Yanjie Xie, Heng Zhou, Wenxue Guan, Guan, Wenxue, Finkemeier, I, Xie, Y, Young, D, Wilson, MH, Tossounian, M-A, Zhou, H, Shen, W, Tossounian, Maria-Armineh, Jingjing Huang, Foyer, CH, Christine H. Foyer, Yang, Xibin, Yang, X, Joris Messens, Wei, Bo, Wenbiao Shen, Foyer, Christine H, David Young, Huang, J, Xibin Yang, Jun Zhu, Wilson, Michael H, Messens, Joris, Zhu, Jun, Young, David, Maria-Armineh Tossounian   +41 more
core   +2 more sources

Global analysis of protein lysine succinylation profiles in common wheat

BMC Genomics, 2017
Background Protein lysine succinylation is an important post-translational modification and plays a critical regulatory role in almost every aspects of cell metabolism in both eukaryotes and prokaryotes.
Yumei Zhang, Guangyuan Wang, Limin Song, Ping Mu, Shu Wang, Wenxing Liang, Qi Lin   +6 more
doaj   +1 more source

Dynamic Responses of Barley Root Succinyl-Proteome to Short-Term Phosphate Starvation and Recovery

Frontiers in Plant Science, 2021
Barley (Hordeum vulgare L.)—a major cereal crop—has low Pi demand, which is a distinct advantage for studying the tolerance mechanisms of phosphorus deficiency.
Juncheng Wang, Juncheng Wang, Zengke Ma, Zengke Ma, Chengdao Li, Panrong Ren, Panrong Ren, Lirong Yao, Lirong Yao, Baochun Li, Yaxiong Meng, Yaxiong Meng, Xiaole Ma, Xiaole Ma, Erjing Si, Erjing Si, Ke Yang, Ke Yang, Xunwu Shang, Huajun Wang, Huajun Wang   +20 more
doaj   +1 more source

Sirt5-mediated desuccinylation of OPTN protects retinal ganglion cells from autophagic flux blockade in diabetic retinopathy

Cell Death Discovery, 2022
Retinal neurodegeneration develops early in the course of diabetic retinopathy (DR), and our previous research showed that succinate accumulation results in retinal ganglion cells (RGCs) dysfunction in the retinas of rats with DR.
Ye Zhang, Tingting Li, Xuan Cai, Da Long, Xiangning Wang, Chang Liu, Qiang Wu   +6 more
doaj   +1 more source