Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum [PDF]
BMC Genomics, 2019 Background Ganoderma lucidum, one of the best-known medicinal mushrooms in the world, produces more than 400 different bioactive compounds. However, the regulation of these bioactive compounds biosynthesis is still unclear.
Guangyuan Wang +4 more
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SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma
Advanced Science, 2023 Mitochondrial dysfunction and abnormal energy metabolism are major features of cancer. However, the mechanisms underlying mitochondrial dysfunction during cancer progression are far from being clarified. Here, it is demonstrated that the expression level
Qifan Hu +10 more
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Comprehensive Succinylome Profiling Reveals the Pivotal Role of Lysine Succinylation in Energy Metabolism and Quorum Sensing of Staphylococcus epidermidis [PDF]
Frontiers in Microbiology, 2021 BackgroundLysine succinylation is a newly identified posttranslational modification (PTM), which exists widely from prokaryotes to eukaryotes and participates in various cellular processes, especially in the metabolic processes.
Yiping Zhao +9 more
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Involvement of the Vitamin D Receptor in Energy Metabolism Revealed by Profiling of Lysine Succinylome of White Adipose Tissue [PDF]
Scientific Reports, 2017 Lysine succinylation, emerging as a novel post-translational modification, is closely related to the regulation of diverse biological processes, including many aspects of metabolism.
Yan Lou +7 more
core +3 more sources
Journal of Proteome Research, 2018 Stem-cell differentiation is a complex biological process controlled by a series of functional protein clusters and signaling transductions, especially metabolism-related pathways.
Qing-bin Zhang (5434250) +8 more
core +5 more sources
Quantitative global proteome and lysine succinylome analyses provide insights into metabolic regulation and lymph node metastasis in gastric cancer [PDF]
Scientific Reports, 2017 With the rapid development of high-throughput quantitative proteomic and transcriptomic approaches, the molecular mechanisms of cancers have been comprehensively explored. However, cancer is a multi-dimensional disease with sophisticated regulations, and
Peng Gao +8 more
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Simultaneous Quantification of the Acetylome and Succinylome by One-Pot Affinity Enrichment. [PDF]
PROTEOMICS, 2018 Protein posttranslational modifications (PTMs) are of increasing interest in biomedical research, yet studies rarely examine more than one PTM. One barrier to multi-PTM studies is the time cost for both sample preparation and data acquisition, which ...
Wei, Lei +4 more
core +6 more sources
Molecular & Cellular Proteomics, 2015 Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, remains one of the most prevalent human pathogens and a major cause of mortality worldwide.
Chen, Chuangbin +11 more
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Proteome-Wide Identification of Lysine Succinylation in the Proteins of Tomato (Solanum lycopersicum). [PDF]
PLoS ONE, 2016 Post-translational modification of proteins through lysine succinylation plays important regulatory roles in living cells. Lysine succinylation was recently identified as a novel post-translational modification in Escherichia coli, yeast, Toxoplasma ...
Weibo Jin, Fangli Wu
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LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer [PDF]
Genomics, Proteomics & Bioinformatics, 2023 Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Around 80% of the patients who developed advanced PCa suffered from bone metastasis, with a sharp drop in the survival rate.
Oh Kwang Kwon +14 more
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