Results 11 to 20 of about 423 (139)

Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome [PDF]

Biomolecules
Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC12) that can be chain-shortened four ...
Yuxun Zhang, Bob B. Zhang, Sivakama S. Bharathi, Joanna Bons, Jacob P. Rose, Samah Shah, Steven F. Dobrowolski, Sunder Sims-Lucas, Birgit Schilling, Eric S. Goetzman   +9 more
doaj   +5 more sources

Comprehensive succinylome analyses reveal that hyperthermia upregulates lysine succinylation of annexin A2 by downregulating sirtuin7 in human keratinocytes [PDF]

Journal of Translational Internal Medicine, 2023
Background and Objectives: Local hyperthermia at 44°C can clear multiple human papillomavirus (HPV)-infected skin lesions (warts) by targeting a single lesion, which is considered as a success of inducing antiviral immunity in the human body ...
Zhendong Wei
exaly   +6 more sources

Changes in the Acetylome and Succinylome of Bacillus subtilis in Response to Carbon Source. [PDF]

PLoS ONE, 2015
Lysine residues can be post-translationally modified by various acyl modifications in bacteria and eukarya. Here, we showed that two major acyl modifications, acetylation and succinylation, were changed in response to the carbon source in the Gram ...
Saori Kosono, Masaru Tamura, Shota Suzuki, Yumi Kawamura, Ayako Yoshida, Makoto Nishiyama, Minoru Yoshida   +6 more
doaj   +5 more sources

Quantitative Analysis of the Proteome and the Succinylome in the Thyroid Tissue of High-Fat Diet-Induced Hypothyroxinemia in Rats [PDF]

International Journal of Endocrinology, 2020
Hypothyroidism is a common disease, and its molecular mechanism still needs further investigation. Lysine succinylation is found to be involved in various metabolic processes associated with hypothyroidism.
Baoxiang Hu, Meng Zhao, Dandan Luo, Chunxiao Yu, Shanshan Shao, Lifang Zhao, Yashuang Yang, Xiaohan Zhang, Jiajun Zhao, Ling Gao   +9 more
doaj   +4 more sources

First Succinylome Profiling of Vibrio alginolyticus Reveals Key Role of Lysine Succinylation in Cellular Metabolism and Virulence [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Recent studies have shown that a key strategy of many pathogens is to use post-translational modification (PTMs) to modulate host factors critical for infection.
Fuyuan Zeng, Fuyuan Zeng, Fuyuan Zeng, Huanying Pang, Huanying Pang, Huanying Pang, Huanying Pang, Ying Chen, Ying Chen, Hongwei Zheng, Hongwei Zheng, Wanxin Li, Srinivasan Ramanathan, Rowena Hoare, Sean J. Monaghan, Xiangmin Lin, Jichang Jian, Jichang Jian, Jichang Jian, Jichang Jian   +19 more
doaj   +7 more sources

The first succinylome profile of Trichophyton rubrum reveals lysine succinylation on proteins involved in various key cellular processes [PDF]

BMC Genomics, 2017
Background Dermatophytes, the most common cause of fungal infections, affect millions of individuals worldwide. They pose a major threat to public health because of the severity and longevity of infections caused by dermatophytes and their refractivity ...
Xingye Xu, Tao Liu, Jian Yang, Lihong Chen, Bo Liu, Candong Wei, Lingling Wang, Qi Jin   +7 more
doaj   +4 more sources

The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids [PDF]

Journal of Biological Chemistry, 2021
Acylation modifications, such as the succinylation of lysine, are post-translational modifications and a powerful means of regulating protein activity. Some acylations occur nonenzymatically, driven by an increase in the concentration of acyl group donors.
Vladimír Pevala, Peter Barath, Eva Kutejova   +2 more
exaly   +5 more sources

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity. [PDF]

FEBS J
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Yu D, Gao Y, Luzarowski M, Seebach E, Heitkamp T, Börsch M, Ruppert T, Kubatzky KF.   +7 more
europepmc   +4 more sources

In-depth analysis of the Sirtuin 5-regulated mouse brain malonylome and succinylome using library-free data-independent acquisitions. [PDF]

Proteomics, 2023
Abstract Post‐translational modifications (PTMs) dynamically regulate proteins and biological pathways, typically through the combined effects of multiple PTMs. Lysine residues are targeted for various PTMs, including malonylation and succinylation. However, PTMs offer specific challenges to mass spectrometry‐based proteomics during data acquisition ...
Bons J, Rose J, Zhang R, Burton JB, Carrico C, Verdin E, Schilling B.   +6 more
europepmc   +4 more sources

Conjoint analysis of succinylome and phosphorylome reveals imbalanced HDAC phosphorylation-driven succinylayion dynamic contibutes to lung cancer [PDF]

Briefings in Bioinformatics
Abstract Cancerous genetic mutations result in a complex and comprehensive post-translational modification (PTM) dynamics, in which protein succinylation is well known for its ability to reprogram cell metabolism and is involved in the malignant evolution.
Di Ge, Ronghua Liu, Yifan Guo
exaly   +5 more sources