Results 31 to 40 of about 423 (139)

Sirtuin 5-mediated desuccinylation of Slc25a4 inhibits osteoporosis by enhancing mitochondrial respiration [PDF]

Bone Research
Osteoporosis is a prevalent metabolic bone disorder that develops when osteoclast-mediated bone resorption chronically exceeds osteoblast-driven bone formation.
Jun Chen, Xinquan Jiang
doaj   +2 more sources

Comprehensive analysis of the lysine acetylome in Aeromonas hydrophila reveals cross-talk between lysine acetylation and succinylation in LuxS

Emerging Microbes and Infections, 2019
Lysine acetylation and succinylation are both prevalent protein post-translational modifications (PTMs) in bacteria species, whereas the effect of the cross-talk between both PTMs on bacterial biological function remains largely unknown.
Lina Sun, Zujie Yao, Zhuang Guo, Lishan Zhang, Yuqian Wang, Ranran Mao, Yuexu Lin, Yuying Fu, Xiangmin Lin   +8 more
doaj   +2 more sources

Sirtuin 5‐Mediated Desuccinylation of ALDH2 Alleviates Mitochondrial Oxidative Stress Following Acetaminophen‐Induced Acute Liver Injury

Advanced Science
Acetaminophen (APAP) overdose is a major cause of drug‐induced liver injury. Sirtuins 5 (SIRT5) has been implicated in the development of various liver diseases. However, its involvement in APAP‐induced acute liver injury (AILI) remains unclear.
Qiwen Yu, Jiakai Zhang, Jiye Li, Yaodong Song, Jie Pan, Chaopeng Mei, Mengwei Cui, Qianqian He, Haifeng Wang, Huihui Li, Bo Cheng, Yan Zhang, Wenzhi Guo, Changju Zhu, Sanyang Chen   +14 more
doaj   +2 more sources

The crotonylated and succinylated proteins of jujube involved in phytoplasma-stress responses [PDF]

BMC Biology
Background Protein posttranslational modifications (PTMs) are fast and early responses to environmental changes, including pathogen infection. Jujube witches’ broom (JWB) is a phytoplasma disease causing great economic loss in jujube production.
Liman Zhang, Huibin Wang, Chaoling Xue, Yin Liu, Yao Zhang, Zhiguo Liu, Xiangrui Meng, Mengjun Liu, Jin Zhao   +8 more
doaj   +2 more sources

Proteome and Acetyl-Proteome Profiling of Camellia sinensis cv. ‘Anji Baicha’ during Periodic Albinism Reveals Alterations in Photosynthetic and Secondary Metabolite Biosynthetic Pathways

Frontiers in Plant Science, 2017
Tea leaf color is not only important from an aesthetics standpoint but is also related to tea quality. To investigate the molecular mechanisms that determine tea leaf color, we examined Camellia sinensis cv.
Yan-Xia Xu, Wei Chen, Chun-Lei Ma, Si-Yan Shen, Yan-Yan Zhou, Lian-Qi Zhou, Liang Chen   +6 more
doaj   +2 more sources

Systematic identification of mitochondrial lysine succinylome in silkworm ( Bombyx mori ) midgut during the larval gluttonous stage

Journal of Proteomics, 2018
Lysine succinylation is a newly identified protein post-translational modification (PTM) of lysine residues. Increasing evidences demonstrate that this modification is prevalent in mitochondria and regulates many vital cellular processes, especially metabolism. Here, we determined the succinylome of the silkworm (Bombyx mori) midgut mitochondria during
Yan Liu, Xin Du, Zhiqi Meng, Jine Chen, Weifeng Shen, Lihua He, Fengbo Li, Yongqiang Wang, Xianliang Ma   +8 more
core   +3 more sources

DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling. [PDF]

Cancer Commun (Lond), 2023
Cancer Communications, Volume 43, Issue 7, Page 838-843, July 2023.
Mellid S, García F, Leandro-García LJ, Díaz-Talavera A, Martínez-Montes ÁM, Gil E, Calsina B, Monteagudo M, Letón R, Roldán-Romero JM, Santos M, Lanillos J, Valdivia C, Martínez-Puente N, de Nicolás-Hernández J, Jiménez S, Pérez-Martínez M, Honrado E, Coloma J, Cerezo A, Santiveri CM, Esteller M, Campos-Olivas R, Caleiras E, Montero-Conde C, Rodríguez-Antona C, Muñoz J, Robledo M, Cascón A.   +28 more
europepmc   +2 more sources

Protein Succinylation and Malonylation as Potential Biomarkers in Schizophrenia. [PDF]

J Pers Med, 2022
Two protein post-translational modifications, lysine succinylation and malonylation, are implicated in protein regulation, glycolysis, and energy metabolism.
Smith BJ, Brandão-Teles C, Zuccoli GS, Reis-de-Oliveira G, Fioramonte M, Saia-Cereda VM, Martins-de-Souza D.   +6 more
europepmc   +2 more sources

Additional file 1: of Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum

, 2019
Three mass spectrometry examples of the succinylpeptides (Figure S1); Western blotting analysis with GAPDH antibody and succinyllysine antibody (Figure S2); GO-based enrichment analysis (Figure S3); Domain enrichment analysis of the succinylproteins ...
Guangyuan Wang (3938942), Jie Gao (10266), Hao Yu (157186), Lili Xu (257856), Lizhong Guo (4021547)   +4 more
core   +2 more sources

SIRT5-Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate-Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis. [PDF]

Adv Sci (Weinh)
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Jiang Q, Dong C, Liu Y, Lou Y, Lin W, Li S, He Z.   +6 more
europepmc   +2 more sources