Results 141 to 150 of about 17,627 (184)

Characterization of a sulfated fucan-specific carbohydrate-binding module: A promising tool for investigating sulfated fucans

Carbohydrate Polymers, 2022
Sulfated fucans are important polysaccharides with diverse biological and biomedical activities. Carbohydrate-binding modules (CBMs) could serve as beneficial tools for the investigation of polysaccharides. Nevertheless, no sulfated fucan-binding CBM has been hitherto discovered.
Xuanwei, Mei, Yaoguang, Chang, Jingjing, Shen, Yuying, Zhang, Guangning, Chen, Yanyan, Liu, Changhu, Xue   +6 more
openaire   +2 more sources

Structure and Anticoagulant Activity of a Sulfated Fucan From the Sea Cucumber Acaudina Leucoprocta

International Journal of Biological Macromolecules, 2020
A sulfated fucan was extracted, purified, and characterized from Acaudina leucoprocta (a low value sea cucumber) to better understand and utilize this species. The structure of the sulfated fucan was elucidated using chemical and modern spectroscopic analyses including HPGPC, IR, AFM, GC-MS, and NMR, and its bioactivity was investigated.
Laijin Su, Shanggui Deng, Yin Chen
exaly   +3 more sources

In Vitro and in Vivo Immunoregulatory Activity of Sulfated Fucan From the Sea Cucumber a. Leucoprocta

International Journal of Biological Macromolecules, 2021
The in vitro and in vivo immunoregulatory activity of a water-soluble sulfated fucan AL1-1 from the sea cucumber A. leucoprocta was elucidated. In vitro experiments showed that AL1-1 up-regulated immunostimulatory activities in RAW264.7 cells and that it could successfully promote ROS production and phagocytic activity, increase secretion levels of ...
Shoudong Guo, Laijin Su
exaly   +3 more sources

A sulfated α-l-fucan from sea cucumber

Carbohydrate Research, 1994
A purified sulfated alpha-L-fucan from the sea cucumber body wall was studied, before and after almost complete desulfation, using methylation analysis and NMR spectroscopy. NMR analysis indicates that 2,4-di-O-sulfo-L-fucopyranose and unsubstituted fucopyranose are present in equal proportions, and that 2-O-sulfo-L-fucopyranose is present in twice ...
A C, Ribeiro, R P, Vieira, P A, Mourão, B, Mulloy   +3 more
openaire   +2 more sources

Relationship between Sulfate Groups and Biological Activities of Fucans

Thrombosis Research, 2000
The anticoagulant and antiproliferative effects of low molecular weight fucans with different sulfate content were examined. The anticoagulant activity was determined by activated partial thromboplastin time and the antiproliferative one was achieved in vitro on CCL39 fibroblast cell line.
F, Haroun-Bouhedja, M, Ellouali, C, Sinquin, C, Boisson-Vidal   +3 more
openaire   +2 more sources

A Comprehensive Review of Sulfated Fucan From Sea Cucumber: Antecedent and Prospect

Carbohydrate Polymers
Sulfated fucan from sea cucumber is mainly consists of L-fucose and sulfate groups. Recent studies have confirmed that the structure of sulfated fucan mainly consists of repeating units, typically tetrasaccharides. However, there is growing evidence indicating the presence of irregular domains with heterogeneous units that have not been extensively ...
Guangning Chen, Xuanwei Mei, Jingjing Shen   +2 more
exaly   +3 more sources

Conformation of sulfated galactan and sulfated fucan in aqueous solutions: Implications to their anticoagulant activities

Journal of Molecular Graphics and Modelling, 2007
The discovery of sulfated galactans and sulfated fucans in marine invertebrates with simple and ordered structures opened new perspectives to investigate the biological activity of these molecules and to determine whether different structures confer high affinity for a particular protein. We undertook a conformational analysis of a 2-sulfated, 3-linked
Camila F, Becker, Jorge A, Guimarães, Paulo A S, Mourão, Hugo, Verli   +3 more
openaire   +2 more sources

Searching for Alternatives to Heparin Sulfated Fucans from Marine Invertebrates

Trends in Cardiovascular Medicine, 1999
We describe a variety of sulfated polysaccharides with regular and well-defined structures which are useful tools for elucidating structure/biological function relationship. Several of these compounds have anticoagulant and antithrombotic activities.
P A, Mourão, M S, Pereira
openaire   +2 more sources

Role of basic amino acids in the interaction of bindin with sulfated fucans

Biochemistry, 1988
Bindin, the acrosomal sperm adhesion protein of the sea urchin Strongylocentrotus purpuratus, binds specifically and with high affinity (Kd = 10(-8) M) to egg sulfated fucans in the high ionic strength milieu of seawater (0.55 M salt). Previous studies indicated that the negatively charged sulfate groups of the polysaccharide are critical for binding ...
P L, DeAngelis, C G, Glabe
openaire   +2 more sources

Antithrombin activity of a fucan sulfate from the brown seaweed Ecklonia kurome

Thrombosis Research, 1991
The mechanism of antithrombin action of a fucan sulfate (C-II), which was isolated from the brown seaweed Ecklonia kurome, was examined by clotting method using a thrombin-fibrinogen system and by amidolytic method using a chromogenic substrate in the presence and the absence of antithrombin III (AT III) or heparin cofactor II (HC II).
T, Nishino, Y, Aizu, T, Nagumo
openaire   +2 more sources