Results 161 to 170 of about 1,141 (196)

A highly regular fucan sulfate from the sea cucumber Stichopus horrens

Carbohydrate Research, 2018
A highly regular fucan sulfate SHFS was isolated from the sea cucumber Stichopus horrens by extraction of the body walls in the presence of papain followed by ion-exchange and gel permeation chromatography. SHFS had MW of about 140 kDa and contained fucose and sulfate in the molar ratio of about 1:1.
Nadezhda E, Ustyuzhanina, Maria I, Bilan, Andrey S, Dmitrenok, Elizaveta Yu, Borodina, Nikolay E, Nifantiev, Anatolii I, Usov   +5 more
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Conformation of sulfated galactan and sulfated fucan in aqueous solutions: Implications to their anticoagulant activities

Journal of Molecular Graphics and Modelling, 2007
The discovery of sulfated galactans and sulfated fucans in marine invertebrates with simple and ordered structures opened new perspectives to investigate the biological activity of these molecules and to determine whether different structures confer high affinity for a particular protein. We undertook a conformational analysis of a 2-sulfated, 3-linked
Camila F, Becker, Jorge A, Guimarães, Paulo A S, Mourão, Hugo, Verli   +3 more
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Inhibition of complement activation by natural sulfated polysaccharides (fucans) from brown seaweed

Molecular Immunology, 1994
In the present study, we demonstrate that natural sulfated polysaccharides (fucans) isolated from brown seaweed are potent inhibitors of human complement activation. A fucan fraction of chromatographic molecular weight 22,600, termed BS8, was found to inhibit classical and alternative pathway activation in whole serum in a dose-dependent fashion. Fucan
C, Blondin, E, Fischer, C, Boisson-Vidal, M D, Kazatchkine, J, Jozefonvicz   +4 more
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Five distinct fucan sulfates from sea cucumber Pattalus mollis: Purification, structural characterization and anticoagulant activities

International Journal of Biological Macromolecules, 2021
Fucan sulfates from echinoderm possess characteristic structures and various biological activities. Herein, comprehensive methods including enzymolysis, ion-exchange chromatography and size exclusion chromatography lead to the purification of five fucan sulfates (FSI, FSII, FSIII, FSIV, FSV) from the sea cucumber Pattalus mollis.
Yan, Ma, Na, Gao, Zhichuang, Zuo, Shanni, Li, Wenqi, Zheng, Xiang, Shi, Qipei, Liu, Ting, Ma, Ronghua, Yin, Xian, Li, Jinhua, Zhao   +10 more
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Antithrombin activity of a fucan sulfate from the brown seaweed Ecklonia kurome

Thrombosis Research, 1991
The mechanism of antithrombin action of a fucan sulfate (C-II), which was isolated from the brown seaweed Ecklonia kurome, was examined by clotting method using a thrombin-fibrinogen system and by amidolytic method using a chromogenic substrate in the presence and the absence of antithrombin III (AT III) or heparin cofactor II (HC II).
T, Nishino, Y, Aizu, T, Nagumo
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Selective 2-desulfation of tetrasaccharide-repeating sulfated fucans during oligosaccharide production by mild acid hydrolysis

Carbohydrate Polymers, 2023
Sulfated fucans (SFs) from echinoderms, such as sea cucumbers and sea urchins, present linear and regular sulfation patterns within defined oligosaccharide building blocks. The high molecular weights of these polymers pose a problem in advanced structure-activity relationship studies for which derived oligosaccharides are more appropriate tools for ...
Seon Beom, Kim, Marwa, Farrag, Sushil K, Mishra, Sandeep K, Misra, Joshua S, Sharp, Robert J, Doerksen, Vitor H, Pomin   +6 more
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Polysaccharides from the brown seaweed Padina tetrastromatica: Characterization of a sulfated fucan

Carbohydrate Polymers, 2009
Sulfated fucans, the complex polysaccharides from brown seaweeds, possess various biological activities. To understand the structure activity relationship of sulfated fucans, we have investigated the structural features of one such polymer from Padina tetrastromatica using standard methods of carbohydrate structural analysis.
Tuhin Ghosh, Sudipta Saha, Bimalendu Ray
exaly   +2 more sources

A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity

Carbohydrate Polymers, 2021
Marine sulfated polysaccharides have aroused widespread concern for their various structures and bioactivities. Peroxide depolymerization is a common strategy in analysis of structures and structure-activity relationships of polysaccharides. However, confirming the depolymerization process and exact structures of the degradation products is still a ...
Xiaomei, Li, Shanni, Li, Jie, Liu, Lisha, Lin, Huifang, Sun, Wenjiao, Yang, Ying, Cai, Na, Gao, Lutan, Zhou, Hongbo, Qin, Ronghua, Yin, Jinhua, Zhao   +11 more
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Mild acid hydrolysis on Fucan sulfate from Stichopus herrmanni: Structures, depolymerization mechanism and anticoagulant activity

Food Chemistry, 2022
Fucan sulfate (FS) from sea cucumbers possesses linear sequences with repeating units that differ principally in the pattern of sulfation and position of glycosidic linkage. FS from Stichopus herrmanni (ShFS) was preliminarily identified as the relatively simple structure {-3)-L-Fuc2S-(α1-}n.
Xiaomei, Li, Huifang, Sun, Zimo, Ning, Wenjiao, Yang, Ying, Cai, Ronghua, Yin, Jinhua, Zhao   +6 more
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Role of basic amino acids in the interaction of bindin with sulfated fucans

Biochemistry, 1988
Bindin, the acrosomal sperm adhesion protein of the sea urchin Strongylocentrotus purpuratus, binds specifically and with high affinity (Kd = 10(-8) M) to egg sulfated fucans in the high ionic strength milieu of seawater (0.55 M salt). Previous studies indicated that the negatively charged sulfate groups of the polysaccharide are critical for binding ...
P L, DeAngelis, C G, Glabe
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