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Depolymerization of sulfated polysaccharides under hydrothermal conditions
Carbohydrate Research, 2014Fucoidan and chondroitin sulfate, which are well known sulfated polysaccharides, were depolymerized under hydrothermal conditions (120-180°C, 5-60min) as a method for the preparation of sulfated polysaccharides with controlled molecular weights. Fucoidan was easily depolymerized, and the change of the molecular weight values depended on the reaction ...
Minoru, Morimoto +11 more
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Induction of Colorectal Tumors in Rats by Sulfated Polysaccharides
CRC Critical Reviews in Toxicology, 1987Some sulfated polysaccharides, such as d-CGN, APS, and DSS, have carcinogenicity to the rat colorectum. These materials first induced colitis, secondly squamous metaplasia, and finally tumors at the colorectum. Initially, colitis was located in the columnar epithelium of the rectum and extended proximally thereafter.
Tomonori Ishioka +4 more
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Sulfated polysaccharides of the red seaweeds
Food Hydrocolloids, 1992Abstract This review is concerned with the latest concepts on the chemical structures of sulfated polysaccharides obtained from the red seaweeds and with some investigations in this field carried out at the Institute of Organic Chemistry in Moscow.
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Comparison of the anticoagulant activity of three polysaccharide sulfates
Archives of Biochemistry and Biophysics, 1963Abstract Amylose, amylopectin, and guaran at different molecular weight levels and at different degrees of sulfation are compared with heparin as anticoagulants for human blood. While molecular weight has only a small effect on in vitro anticoagulant action, activity increases with sulfate ester content and is most pronounced in the branched ...
W M, DOANE, R L, WHISTLER
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Sulfated polysaccharides and nanotechnology
2015Sulfated polysacchar ides (SPs) are a complex group of biomolecules, many of which present relevant biological activities, such as antibiotic, anti-oxidant, anti-mutant, anticoagulant, antiviral, antitumor, anti-inflammatory, immunomodu latory. Additionally, being biocompatible, biodegradable and suitable for processing into membranes, hydrogels and ...
Carvalho, Vera Maria Rego Silva +1 more
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Control of Angiogenesis by Heparin and Other Sulfated Polysaccharides
1992Heparin and its related polysaccharides are revealed to have important new functions as regulators of blood vessel growth and regression. This regulatory activity may be explained in part by at least five mechanisms in which heparin and heparan sulfate interact with peptide growth factors: (1) Heparin and heparan sulfate have a high affinity for ...
J, Folkman, Y, Shing
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[Hypolipidemic effect of sulfated polysaccharides].
Voprosy meditsinskoi khimii, 1997In experiments on hyperlipidemic rats it was observed the hypolipidemic effect of new sulfated polisaccharides-chitosan, lutelan and krilan sulfates, More pronounced decrease was established in VLDL and increase of HDL after sulfated polysaccharides treatment. The most distinct efficiency exhibites preparation with moledular mass of 20-40 x 10(3) D and
V E, Ryzhenkov +3 more
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Biosynthesis of chondroitin sulfate. Sulfation of the polysaccharide chain
Biochemistry, 1973S, DeLuca, M E, Richmond, J E, Silbert
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[Anticoagulant activity of sulfated polysaccharides].
Eksperimental'naia i klinicheskaia farmakologiia, 2007The paper reviews published data on the chemical structure of sulfated polysaccharides of animal, plant, and microbial origin as well as synthetic or semi-synthetic derivatives, and on the anticoagulant activity of these compounds in vitro and in vivo.
N N, Drozd +3 more
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