Results 71 to 80 of about 3,243 (149)

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

In Situ Structural Characterization of Glycerophospholipids and Sulfatides in Brain Tissue Using MALDI-MS/MS [PDF]

open access: yes, 2007
Lipids are major structural components of biomembranes. Negatively charged species such as phosphatidylinositol, phosphatidylserine, sulfatides, and the zwitterionic phosphatidylethanolamines are major components of the cytoplasmic surface of the ...
Woods, Amina S.   +2 more
core   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

open access: yeseFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy   +7 more
wiley   +1 more source

PREPARATION OF SPIN-LABELED SULFATIDES FOR ELECTRON-PARAMAGNETIC-RES STUDIES ON MODEL MEMBRANES

open access: yes, 1987
Using the N-hydroxysuccinimide ester of the fatty acids, galactosylceramide I3-sulfate containing a 5-or 16-doxyl-stearoyl residue was prepared in good yield by acylation of the galactosylsphingosine I3-sulfate (lysosulfatide) obtained from the ...
D. MONTI   +5 more
core   +2 more sources

Metachromatic Leucodystrophy: A Case Report

open access: yesJournal of Karnali Academy of Health Sciences, 2021
Metachromatic leukodystrophy (MLD) is a rare autosomal recessive inherited disease, which is caused by a deficiency in the enzyme activity of Arylsulfatase A (ARSA). Deficiency of this enzyme results in intralysosomal storage of sphingolipid cerebroside
Ramchandra Bastola   +3 more
doaj   +2 more sources

Metachromatic leukodystrophy: A case report

open access: yesBangabandhu Sheikh Mujib Medical University Journal, 2016
Metachromatic leuk:odystrophy (MLD) is a rare neurometabolic disease caused by the deficiency of the enzyme arylsulfa­tase A .Deficiency of this enzyme results in intralysosomal storage ofsphingolipid , cerebroside 3-sulfates (sulfatides), which are ...
Gopen Kumar Kundu   +2 more
doaj   +1 more source

Altered Plasma, Urine, and Tissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma

open access: yes, 2022
Purpose: RCC, the most common type of kidney cancer, is associated with high mortality. A non-invasive diagnostic test remains unavailable due to the lack of RCC-specific biomarkers in body fluids.
Hana Študentová   +19 more
core   +1 more source

AAV-Mediated Gene Delivery in a Feline Model of Sandhoff Disease Corrects Lysosomal Storage in the Central Nervous System

open access: yesASN Neuro, 2015
Sandhoff disease (SD) is an autosomal recessive neurodegenerative disease caused by a mutation in the gene for the β-subunit of β-N-acetylhexosaminidase (Hex), resulting in the inability to catabolize ganglioside GM2 within the lysosomes.
Hannah E. Rockwell   +13 more
doaj   +1 more source

Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis

open access: yesTH Open, 2019
The contributions of coagulation factor XI (FXI) and FXII to human clot formation is not fully known. Patients with deficiency in FXI have a variable mild bleeding risk, whereas FXII deficiency is not associated with bleeding.
José W. P. Govers-Riemslag   +7 more
doaj   +1 more source

Central Precocious Puberty in a Child With Metachromatic Leukodystrophy

open access: yesFrontiers in Endocrinology, 2018
Metachromatic leucodystrophy (MLD) is a rare inherited lysosomal disorder caused by reduced activity of the enzyme arylsulfatase A with accumulation of sulfatides in the nervous system.
Gilda Belli   +6 more
doaj   +1 more source

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