Results 151 to 160 of about 2,318 (179)
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A colorimetric assay for sulfiredoxin activity using inorganic phosphate measurement
Analytical Biochemistry, 20092-Cys peroxiredoxin (Prx) is the major subgroup of a family of Prx enzymes that reduce peroxide molecules such as hydrogen peroxide (H(2)O(2)). 2-Cys Prxs are inactivated when their active site cysteine residue is hyperoxidized to sulfinic acid. Sulfiredoxin (Srx) is an enzyme that catalyzes reduction of hyperoxidized 2-Cys Prxs in the presence of ATP,
Hojin, Kim +4 more
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Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages
Free Radical Biology and Medicine, 2011Peroxiredoxins (Prx's) are a family of peroxidases that maintain thiol homeostasis by catalyzing the reduction of organic hydroperoxides, H₂O₂, and peroxynitrite. Under conditions of oxidative stress, eukaryotic Prx's can be inactivated by the substrate-dependent oxidation of the catalytic cysteine to sulfinic acid, which may regulate the intracellular
Abbas, Kahina +8 more
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Israa University Journal for Applied Science
Background: Chronic kidney disease (CKD) is a progressive disorder defined by a persistent reduction in glomerular filtration rate below 60 mL/min/1.73 m² for at least three months.
R. I. Atiyah +2 more
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Background: Chronic kidney disease (CKD) is a progressive disorder defined by a persistent reduction in glomerular filtration rate below 60 mL/min/1.73 m² for at least three months.
R. I. Atiyah +2 more
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1H, 15N, and 13C Chemical Shift Assignments of the Human Sulfiredoxin (hSrx)
Journal of Biomolecular NMR, 2005Electronic supplementary material Electronic supplementary material is available for this article at http://dx.doi.org/10.1007/s10858-005-0472-6 and accessible for authorised users.
Duck-Yeon, Lee +3 more
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Biochemical and Biophysical Research Communications - BBRC, 2019
Hyperglycemia-induced podocyte injury plays a vital role in the development of diabetic nephropathy. Sulfiredoxin-1 (Srxn1) is emerging as a cytoprotective protein that protects from various insults in a wide range of cell types.
Yan Shen, Sheng-Nan Chen, Yan Zhao
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Hyperglycemia-induced podocyte injury plays a vital role in the development of diabetic nephropathy. Sulfiredoxin-1 (Srxn1) is emerging as a cytoprotective protein that protects from various insults in a wide range of cell types.
Yan Shen, Sheng-Nan Chen, Yan Zhao
semanticscholar +1 more source
Effective killing of cancer cells and regression of tumor growth by K27 targeting sulfiredoxin
Free Radical Biology and Medicine, 2016Cancer cells have been suggested to be more susceptible to oxidative damages and highly dependent on antioxidant capacity in comparison with normal cells, and thus targeting antioxidant enzymes has been a strategy for effective cancer treatment. Sulfiredoxin (Srx) is an enzyme that catalyzes the reduction of sulfinylated peroxiredoxins and thereby ...
Jiwon, Kim +11 more
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ROLE OF SULFIREDOXIN INTERACTING PROTEINS IN LUNG CANCER DEVELOPMENT
2016Sulfiredoxin (Srx) is an antioxidant enzyme that can be induced by oxidative stress. It promotes oncogenic phenotypes of cell proliferation, colony formation, migration, and metastasis in lung, skin and colon cancers. Srx reduces the overoxidation of 2-cysteine peroxiredoxins in cells, in addition to its role of removing glutathione modification from ...
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Redox signaling in acute pancreatitis: roles of PGC-1α and sulfiredoxin
2020La pancreatitis aguda es un proceso inflamatorio agudo de la glándula pancreática que conduce frecuentemente a complicaciones locales y sistémicas. En la actualidad, es la principal causa de admisión hospitalaria por enfermedad gastrointestinal y su incidencia ha aumentado considerablemente durante la última década.Entre los mecanismos fisiopatológicos
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