Results 141 to 150 of about 2,318 (179)

Sulfiredoxin-1 protects spinal cord neurons against oxidative stress in the oxygen-glucose deprivation/reoxygenation model through the bax/cytochrome c/caspase 3 apoptosis pathway.

Neuroscience Letters, 2021
BACKGROUND Spinal cord ischemia/reperfusion injury is a common clinical, pathophysiological phenomenon with complex molecular mechanisms. Currently, there are no therapeutics available to alleviate the same. This study investigates the protective effects
W.-M. Lan, Jian-Hua Lin, Wei-Nan Liu, Fasheng Wang, Yun Xie   +4 more
semanticscholar   +1 more source

Comparative estimation of sulfiredoxin levels between chronic periodontitis and healthy patients – A case‐control study

The Journal of Periodontology, 2018
BACKGROUND Growing evidence suggests that oxidative stress forms a key component in the etiopathogenesis of periodontitis. Studies have shown potential antioxidants responsible for combating the pro-oxidants which stress the periodontium.
A. Ramesh, S. Varghese, N. Jayakumar, S. Malaiappan   +3 more
semanticscholar   +1 more source

Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression

Free Radical Biology and Medicine, 2012
Peroxiredoxins (Prxs) constitute a family of peroxidases in which cysteine serves as the primary site of oxidation during the reduction of peroxides. Members of the 2-Cys Prx subfamily of Prxs (Prx I to IV in mammals) are inactivated via hyperoxidation of the active-site cysteine to sulfinic acid (Cys-SO(2)H) during catalysis and are reactivated via an
Woojin, Jeong, Soo Han, Bae, Michel B, Toledano, Sue Goo, Rhee   +3 more
openaire   +2 more sources

Peroxiredoxins and Sulfiredoxin at the Crossroads of the NO and H2O2 Signaling Pathways

2013
Peroxiredoxins (Prxs) are a family of peroxidases that maintain thiol homeostasis by catalyzing the reduction of organic hydroperoxides, H2O2, and peroxynitrite. Eukaryotic 2-Cys-Prxs, also referred to as typical Prxs, can be inactivated by oxidation of the catalytic cysteine to sulfinic acid, which may regulate the intracellular messenger function of ...
Abbas, Kahina, Riquier, Sylvie, Drapier, Jean-Claude   +2 more
openaire   +2 more sources

Sulfiredoxin-1 Accelerates Erastin-Induced Ferroptosis in HT-22 Hippocampal Neurons by Driving Heme Oxygenase-1 Activation.

Free Radical Biology & Medicine
Ferroptosis, a recently identified non-apoptotic form of cell death, is strongly associated with neurological diseases and has emerged as a potential therapeutic target. Nevertheless, the fundamental mechanisms are still predominantly unidentified.
Shihui Guo, Dongxu Zhang, Yingying Dong, Yujia Shu, Xuanfu Wu, Y. Ni, Ru-Qian Zhao, Wenqiang Ma   +7 more
semanticscholar   +1 more source

Sulfiredoxin 1 ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the Sirt1/NLRP3 pathway.

International Immunopharmacology
BACKGROUND Doxorubicin (DOX) is limited in clinical use due to its cardiotoxic side effects. Oxidative stress and inflammation are pivotal mechanisms underlying doxorubicin-induced cardiotoxicity (DIC).
Zhao-Xia Zhang, Tingsha Du, Nan Wu, Shu-Wen Yang, Jian Wang, Jian-Ye Peng, Zhenyu Jia, Jiating Dai, Xian-Feng Du, M. Feng, Hui-Min Chu, Cai-Jie Shen   +11 more
semanticscholar   +1 more source

"Candida glabrata peroxiredoxins, Tsa1 and Tsa2, and sulfiredoxin, Srx1, protect against oxidative damage and are necessary for virulence".

Fungal Genetics and Biology, 2020
Candida glabrata is an opportunistic fungal pathogen that can cause life-threatening infections in immunocompromised patients. To ensure a successful infection, C. glabrata has evolved a variety of strategies to avoid killing within the host.
Guadalupe Gutiérrez-Escobedo, Oscar Hernández-Carreón, Brenda Morales-Rojano, Brenda Revuelta-Rodríguez, Norma C. Vázquez-Franco, I. Castaño, A. De Las Peñas   +6 more
semanticscholar   +1 more source

Sulfiredoxin-1 promotes the growth of hepatocellular carcinoma by inhibiting TFEB-mediated autophagy and lysosome biogenesis.

Experimental Cell Research
Advanced hepatocellular carcinoma (HCC) patients have poor prognosis. As an endogenous antioxidant enzyme involved in a variety of bioprocesses, sulfiredoxin-1 (SRXN1) plays an irreplaceable role in promoting the development of tumors.
Qian-Wen Rao, Meng-Zhou Guo, Jia-Lei Sun, Bi-Wei Yang, Xin Cao, Jinglin Xia   +5 more
semanticscholar   +1 more source

Sulfiredoxin involved in the protection of peroxiredoxins against hyperoxidation in the early hyperglycaemia

Experimental Cell Research, 2017
As a direct consequence of hyperglycaemia, the excessive generation of ROS is central to the pathogenesis of diabetic cardiomyopathy. We hypothesize that stimulation of high glucose (HG) results in an increased sulfiredoxin (Srx) expression, which regulates ROS signaling through reducing the hyperoxidized peroxiredoxins (Prxs).
Sa, Shi, Yunqiu, Guo, Yanping, Lou, Quanfeng, Li, Xiaona, Cai, Xin, Zhong, Hong, Li   +6 more
openaire   +2 more sources

Unraveling the role of sulfiredoxin-1 in early-onset preeclampsia: A key player in trophoblast ferroptosis.

Journal of Reproductive Immunology
Preeclampsia (PE) significantly contributes to obstetric complications and maternal mortality, yet its pathogenesis and mechanisms are not well understood.
Jia-Chun Wei, Di Qiu, Xiaofeng Yang, Jian Wang, M. Shi, Lu Sun, Xin-Yao Lu, Caihong Wang, Haizhi Liu, Rui-Man Li   +9 more
semanticscholar   +1 more source