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Sulfiredoxin: a potential therapeutic agent? [PDF]
Biomedicine and Pharmacotherapy, 2005 The importance of antioxidants in maintaining homeostasis has long been accepted and includes antioxidant proteins such as, peroxiredoxin (Prx), superoxide dismutase and glutathione S transferases. Sulfiredoxin (Srx) is a recently identified antioxidant protein with a role in signaling through catalytic reduction of oxidative modifications.
Victoria Findlay, Haim Tapiero
exaly +3 more sources
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin [PDF]
Molecules and Cells, 2009 "Two-cysteine" peroxiredoxins are antioxidant enzymes that exert a cytoprotective effect in many models of oxidative stress. However, under highly oxidizing conditions they can be inactivated through hyperoxidation of their peroxidatic active site cysteine residue. Sulfiredoxin can reverse this hyperoxidation, thus reactivating peroxiredoxins.
Lyndsay M Murray +2 more
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Journal of Molecular Graphics and Modelling, 2019
When intracellular reactive oxygen species (ROS) increase, cancer cells are more vulnerable to oxidative stress compared to normal cells; thus, the collapse of redox homeostasis can lead to selective death of cancer cells.
Minsup Kim +4 more
semanticscholar +3 more sources
When intracellular reactive oxygen species (ROS) increase, cancer cells are more vulnerable to oxidative stress compared to normal cells; thus, the collapse of redox homeostasis can lead to selective death of cancer cells.
Minsup Kim +4 more
semanticscholar +3 more sources
Reversal of 2-Cys peroxiredoxin oligomerization by sulfiredoxin
Biochemical and Biophysical Research Communications, 2013Hydrogen peroxide (H(2)O(2)) regulates the structure and function of 2-Cys peroxiredoxins (Prxs). Upon oxidation by excess H(2)O(2), Prxs become overoxidized to a sulfinic acid of its peroxidatic cysteine residue, resulting in a structural change from a small oligomer with peroxidase function to a large oligomer with chaperone function.
Sang Yeol Lee +2 more
exaly +6 more sources
The Journal of Periodontology, 2022
BACKGROUND The delicate balance between oxidative stress and its antioxidant system can be disrupted in diabetes mellitus (DM) making the tissue susceptible to injury.
Fayiz Tk +5 more
semanticscholar +1 more source
BACKGROUND The delicate balance between oxidative stress and its antioxidant system can be disrupted in diabetes mellitus (DM) making the tissue susceptible to injury.
Fayiz Tk +5 more
semanticscholar +1 more source
Biophysical Chemistry, 2022
Human peroxiredoxin (PRX) family of antioxidant enzymes reduces hydrogen peroxide and alkyl hydroperoxide involved in the redox signaling, among which the widely documented PRX1 is a versatile molecule regulating cell growth, differentiation and ...
Xiaoqiong Wu +6 more
semanticscholar +1 more source
Human peroxiredoxin (PRX) family of antioxidant enzymes reduces hydrogen peroxide and alkyl hydroperoxide involved in the redox signaling, among which the widely documented PRX1 is a versatile molecule regulating cell growth, differentiation and ...
Xiaoqiong Wu +6 more
semanticscholar +1 more source
P53 triggers necroptosis through loss of sulfiredoxin in acute pancreatitis
Free Radical Biology and Medicine, 2022S. Rius-Pérez +3 more
semanticscholar +2 more sources
International Immunopharmacology, 2021
Sulfiredoxin-1 (Srxn1) has been acknowledged as a remarkable pro-survival factor in the protection of cells against stress-induced damage. The persistent exposure of retinal ganglion cells (RGCs) to high glucose (HG) in diabetes induces cellular damage ...
Fei-yun Zhu +3 more
semanticscholar +1 more source
Sulfiredoxin-1 (Srxn1) has been acknowledged as a remarkable pro-survival factor in the protection of cells against stress-induced damage. The persistent exposure of retinal ganglion cells (RGCs) to high glucose (HG) in diabetes induces cellular damage ...
Fei-yun Zhu +3 more
semanticscholar +1 more source
The FASEB Journal, 2022
Lung adenocarcinoma is the most common type of lung cancer and has a strong association with tobacco smoking. Smoking leads to the accumulation of reactive oxygen species (ROS) and oxidative stress damages to macromolecules, leading to abnormal cell ...
Yi Hao
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Lung adenocarcinoma is the most common type of lung cancer and has a strong association with tobacco smoking. Smoking leads to the accumulation of reactive oxygen species (ROS) and oxidative stress damages to macromolecules, leading to abnormal cell ...
Yi Hao
semanticscholar +1 more source