Results 21 to 30 of about 86,041 (331)

Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases

open access: yesBiomolecules, 2022
Most neurodegenerative diseases are multifactorial, and the discovery of several molecular mechanisms related to their pathogenesis is constantly advancing.
Thayssa Tavares da Silva Cunha   +7 more
doaj   +1 more source

Point Mutations in the folP Gene Partly Explain Sulfonamide Resistance of Streptococcus mutans

open access: yesInternational Journal of Microbiology, 2013
Cotrimoxazole inhibits dhfr and dhps and reportedly selects for drug resistance in pathogens. Here, Streptococcus mutans isolates were obtained from saliva of HIV/AIDS patients taking cotrimoxazole prophylaxis in Uganda.
W. Buwembo   +4 more
doaj   +1 more source

Novel Coumarin 7-Carboxamide/Sulfonamide Derivatives as Potential Fungicidal Agents: Design, Synthesis, and Biological Evaluation

open access: yesMolecules, 2022
Coumarin compounds have a variety of biological activities such as anti-tumor, anti-coagulation, anti-HIV, anti-fungal, and insecticidal. Amide and sulfonamide compounds have been used as fungicides for half a century, and dozens of varieties have been ...
Shu-Guang Zhang   +3 more
doaj   +1 more source

Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols

open access: yesJournal of the American Chemical Society, 2019
Sulfonamides are key motifs in pharmaceuticals and agrochemicals, spurring the continuous development of novel and efficient synthetic methods to access these functional groups.
G. Laudadio   +6 more
semanticscholar   +1 more source

Xác định gen kháng kháng sinh nhóm sulfonamide của Escherichia coli sinh beta-lactamases phổ rộng phân lập trên cá

open access: yesTạp chí Khoa học Đại học Cần Thơ, 2018
Escherichia coli sinh enzyme beta-lactamases phổ rộng (ESBL-E. coli) là loài vi khuẩn gây nhiều bệnh nguy hiểm cho người và những loài động vật trên cạn. Một số nghiên cứu đã ghi nhận ESBL-E. coli xuất hiện trên cá nuôi và cá tự nhiên, điều đáng quan tâm
Phan Như Ý, Trần Thị Tuyết Hoa
doaj   +1 more source

Analytical Detection of Sulfonamides and Organophosphorus Insecticide Residues in Fish in Taiwan

open access: yesMolecules, 2020
Exposure to residues of antibiotics (e.g., sulfonamides) and insecticides (e.g., organophosphorus insecticides) in aquacultured food can adversely affect humans and animals and thus affect public health globally.
Chung-Pei Chang   +10 more
doaj   +1 more source

Sulfonamides and trimethoprim [PDF]

open access: yesExpert Review of Anti-infective Therapy, 2009
Sulfonamides and trimethoprim are inexpensive and effective antibacterial drugs that have been used extensively. The use of sulfonamides for systemic use has, however, decreased dramatically for several years, mainly because of resistance development in pathogenic bacteria and allergic side effects. Also the clinical efficiency of trimethoprim has been
openaire   +2 more sources

Review of the existing maximum residue levels for amisulbrom according to Article 12 of Regulation (EC) No 396/2005

open access: yesEFSA Journal, 2020
According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance amisulbrom.
European Food Safety Authority (EFSA)   +20 more
doaj   +1 more source

Hydrochlorothiazide Sensitised Acetazolamide induced Bilateral Angle Closure Glaucoma with Choroidal Detachment after Cataract Surgery [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2018
Sulfonamide (Sulfa) derived medications causing bilateral secondary angle closure glaucoma with choroidal effusion is a known but rare clinical entity.
Chitaranjan Mishra   +4 more
doaj   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

open access: yesAngewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu   +16 more
wiley   +2 more sources

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