Results 91 to 100 of about 2,674,072 (303)

Comparative cardiovascular safety of GLP-1 receptor agonists versus other glucose-lowering agents in real-world patients with type 2 diabetes: a nationwide population-based cohort study

Cardiovascular Diabetology, 2020
Background Current evidence about the cardiovascular safety of glucagon-like peptide-1 receptor agonist (GLP-1ra) possesses limited generalizability to real-world patients with type 2 diabetes (T2D) in usual practice.
Chun-Ting Yang, Chen-Yi Yang, Huang-Tz Ou, Shihchen Kuo   +3 more
doaj   +1 more source

A novel mutation of gene in a patient with diazoxide-unresponsive congenital hyperinsulinism [PDF]

Korean Journal of Pediatrics, 2016
Congenital hyperinsulinism (CHI) is a rare condition that can cause irreversible brain damage during the neonatal period owing to the associated hypoglycemia. Hypoglycemia in CHI occurs secondary to the dysregulation of insulin secretion.
Ji Sook Park, Hong-Jun Lee, Chan-Hoo Park   +2 more
doaj   +1 more source

Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations

, 2010
Objective: The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY).
Shield, JPH, Kapoor, RR, Hussain, K., Rubio-Cabezas, O., Kapoor, R. R., Banerjee, I, Sianhanidou, T, Siahanidou, T., Flanagan, SE, Akcay, T, Akcay, T., Cody, D., Siahanidou, T, Hussain, K, Ellard, S., Mali, G, Cody, D, Shield, JP, Shield, J. P. H., Rubio-Cabezas, O, Mali, G., Schwahn, B., Flanagan, S. E., Murphy, N, Murphy, N., Banerjee, I., Ellard, S, Schwahn, B   +27 more
core   +1 more source

A Trp574–Leu substitution confers resistance to three classes of acetolactate synthase inhibitors in Australian brome grass (Bromus diandrus)

Pest Management Science, EarlyView.
Target‐site based imidazolinone resistance in brome grass was found to be conferred by a mutation at position 574 in the ALS gene and to severely impact the efficacy of the herbicide Intervix®, a co‐formulation of imazamox and imazapyr. Abstract BACKGROUND Brome grass (Bromus diandrus) is a prevalent weed in southern Australian cropping regions which ...
Roberto Busi, Danica Goggin, Nick Eyres, Fabian Runge, Aimone Porri, Ken Flower   +5 more
wiley   +1 more source

A Short-activating RNA Oligonucleotide Targeting the Islet β-cell Transcriptional Factor MafA in CD34+ Cells

Molecular Therapy: Nucleic Acids, 2013
Upon functional loss of insulin producing islet β-cells, some patients with diabetes become dependent on life-long insulin supplementation therapy. Bioengineering surrogate insulin producing cells is an alternative replacement strategy. We have developed
Vikash Reebye, Pål Sætrom, Paul J Mintz, John J Rossi, Noriyuki Kasahara, Georgios Nteliopoulos, Joanna Nicholls, Abdelali Haoudi, Myrtle Gordon, Nagy A Habib   +9 more
doaj   +1 more source

Pro‐197 mutations confer resistance to thiencarbazone but not to foramsulfuron in ALS‐resistant Poa annua populations

Pest Management Science, EarlyView.
Foramsulfuron remains effective on Pro‐197 Poa annua, but co‐formulation with thiencarbazone reduces efficacy due to limited activity and antagonism. Therefore, foramsulfuron + thiencarbazone should be used in fields without ALS‐resistant weeds to ensure effective in‐crop control.
Vijaya Bhaskar Alwarnaidu Vijayarajan, Iniya Vijayakumar, Rafa Ruiz‐Partida, Fabian Runge, Joel Torra, Jorge Lozano‐Juste, Patrick Dermot Forristal   +6 more
wiley   +1 more source

Sulfonylurea and neuroprotection: The bright side of the moon

Journal of Advanced Pharmaceutical Technology & Research, 2018
Sulfonylurea (SUR) agents are the second and most used oral hypoglycemic drugs after metformin and they still as an imperative tool for most favorable of glucose control.
Nawar R Hussien, Marwa S Al-Naimi, Huda A Rasheed, Hayder M Al-kuraishy, Ali I Al-Gareeb   +4 more
doaj   +1 more source

Update of mutations in the genes encoding the pancreatic beta‐cell KATP channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism

Human Mutation, 2009
The beta‐cell ATP‐sensitive potassium (KATP) channel is a key component of stimulus‐secretion coupling in the pancreatic beta‐cell. The channel couples metabolism to membrane electrical events bringing about insulin secretion.
S. Flanagan, Séverine Clauin, C. Bellanné-Chantelot, P. de Lonlay, L. Harries, A. Gloyn, S. Ellard   +6 more
semanticscholar   +1 more source

The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes

, 2004
OBJECTIVE - The aim of this study was to investigate whether diabetic patients carrying the Arg(972) insulin receptor substrate-1 (IRS-1) variant are at increased risk for secondary failure to sulfonylurea.
Andreozzi, F, Lauro, D, Cardellini, M, Gnasso A, Irace C, FEDERICI, MASSIMO, FRONTONI, SIMONA, CARDELLINI, MARINA, Sesti G, Frontoni S, Irace, C, Marini MA, Federici, M, Lauro, R., Perticone F, Frontoni, S, Sciacqua A, Sciacqua, A, Perticone, F, Marini, MA, Lauro D, Gnasso, A, Cardellini M, Lauro R, Federici M, Lauro, R, LAURO, DAVIDE, Sesti, G, Andreozzi F, MARINI, MARIA ADELAIDE   +29 more
core   +1 more source

Peri‐operative management of diabetes mellitus: a multidisciplinary consensus statement from the Association of Anaesthetists and the Joint British Diabetes Societies for Inpatient Care group

Anaesthesia, EarlyView.
Summary Introduction Surgery in patients with diabetes mellitus is associated with increased morbidity and mortality compared with those who do not have diabetes mellitus. This is likely multifactorial and could be attributed to organisational issues; dysglycaemia; hospital‐acquired diabetic ketoacidosis; errors with insulin prescribing and ...
Nicholas A. Levy, Kariem El‐Boghdadly, Dileep N. Lobo, Daniel J. Stubbs, Parizad Avari, Donal Buggy, Claire Frank, Kim Howson, Jinty Moffett, Emma Morris, Omar G. Mustafa, Glynn Nash, Pádraig Ó Scanaill, Sarah Procter, Gerry Rayman, Kim Russon, Caroline Thomas, Sarah Tinsley, Allan Xu, Ketan Dhatariya   +19 more
wiley   +1 more source