Results 101 to 110 of about 2,674,072 (303)

Trends in Pharmacological Treatment of Patients With New Onset Type 2 Diabetes: Usage Patterns in an Evolving Guideline Landscape

Journal of Diabetes
Aims In patients with new onset type 2 diabetes, this study aimed to analyze glucose‐lowering medication use patterns between 2014 and 2022. Materials and Methods This retrospective study included adults with incident type 2 diabetes in the University of
William Hou, Katherine R. Tuttle, Weining Shen, Andrew Reikes, Jonathan H. Watanabe   +4 more
doaj   +1 more source

Recognition of Sulfonylurea Receptor (ABCC8/9) Ligands by the Multidrug Resistance Transporter P-glycoprotein (ABCB1)

Journal of Biological Chemistry, 2010
ATP-sensitive K+ (KATP) channels are the target of a number of pharmacological agents, blockers like hypoglycemic sulfonylureas and openers like the hypotensive cromakalim and diazoxide.
A. Bessadok, E. García, H. Jacquet, Solenne Martin, A. Garrigues, N. Loiseau, F. André, S. Orlowski, M. Vivaudou   +8 more
semanticscholar   +1 more source

The sulfonylurea glimepiride regulates intracellular routing of the insulin-receptor complexes through their interaction with specific protein kinase C isoforms

, 2001
Sulfonylureas may stimulate glucose metabolism by protein kinase C (PKC) activation. Because interaction of insulin receptors with PKC plays an important role in controlling the intracellular sorting of the insulin-receptor complex, we investigated the ...
SESTI G, D'ALFONSO, ROSSELLA, Barbara Giovannone, Lauro, D, Liu, YY, FEDERICI, MASSIMO, BORBONI, PATRIZIA, LIU YY, Federici, M, GIOVANNONE B, D'Alfonso, R, Borboni, P, BORBONI P, Yong Yu Liu, Davide Lauro, Hribal, ML, Marta Letizia Hribal, Renato Lauro, HRIBAL ML, Sesti, G., Patrizia Borboni, Massimo Federici, Lauro, R, LAURO R, LAURO, DAVIDE, Rossella D'Alfonso, LAURO D, Giovannone, B, Sesti, G, Giorgio Sesti, D'ALFONSO R, FEDERICI M, LAURO, RENATO   +32 more
core   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Timing and duration of glucagon‐like peptide‐1 receptor agonist use and risk of nonarteritic anterior ischaemic optic neuropathy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate the association between glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) use and nonarteritic anterior ischaemic optic neuropathy (NAION) in type 2 diabetes, examining treatment recency and cumulative duration. Methods This nationwide registry‐based nested case–control study utilizedz Danish health registries (1996 ...
Siar Niazi, Filip Gnesin, Baker Nawfal Jawad, Zia Niazi, Puriya Daniel Wuertz Yazdanfard, Anne P. Toft‐Petersen, Kathrine Kold Sørensen, Amani Meaidi, Yousif Subhi, Christian Torp‐Pedersen   +9 more
wiley   +1 more source

Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date

Drug Design, Development and Therapy, 2018
Zachary A King,1 Kevin N Sheth,1 W Taylor Kimberly,2 J Marc Simard3 1Department of Neurology, Division of Neurocritical Care and Emergency Neurology, Yale University School of Medicine, New Haven, CT, USA; 2Department of Neurology, Division of ...
King ZA, Sheth KN, Kimberly WT, Simard JM   +3 more
doaj  

β2-Adrenergic ion-channel coupled receptors as conformational motion detectors.

PLoS ONE, 2011
Ion Channel-Coupled Receptors (ICCRs) are artificial proteins comprised of a G protein-coupled receptor and a fused ion channel, engineered to couple channel gating to ligand binding.
Lydia N Caro, Christophe J Moreau, Jean Revilloud, Michel Vivaudou   +3 more
doaj   +1 more source

Secular Trend in Glycaemic Management in Type 2 Diabetes Patients With and Without Cirrhosis Between 2000 and 2023: A Territory‐Wide Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In this territory‐wide cohort study, improving glycemic control can be observed regardless of cirrhosis status. Oral antidiabetic medication was more often used in the non‐cirrhosis group, and insulin was preferred in patients with decompensated cirrhosis, who exhibited an increasing incidence of hypoglycemia over the years and need individualized ...
Mary Yue Wang, Sherlot Juan Song, Nana Peng, Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Jimmy Che‐To Lai, Terry Cheuk‐Fung Yip   +6 more
wiley   +1 more source

Minoxidil-Induced Hair Growth is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

, 2001
The mechanism by which minoxidil, an adenosine-triphosphate-sensitive potassium channel opener, induces hypertrichosis remains to be elucidated. Minoxidil has been reported to stimulate the production of vascular endothelial growth factor, a possible ...
Nakaya, Yutaka, Li, Ming, Marubayashi, Azusa, Arase, Seiji, Fukui, Kiyoshi   +4 more
core   +1 more source

Expert considerations to guide the development and delivery of an exercise intervention in people with type 2 diabetes‐related foot ulcer disease

Diabetic Medicine, EarlyView.
Abstract Objective Engaging in exercise presents unique challenges for those with type 2 diabetes (T2D) and diabetes‐related foot ulcer disease (DFUD). This brief report describes the development of practical considerations aiming to support exercise in people with T2D and DFUD.
Vicki L. Johnson, Vicky Hall, Rachel Berrington, Julia Burdon, Sally Schreder, Matthew McCarthy, Chris Brough, Patrick J. Highton, Michelle Hadjiconstantinou, Frances L. Game, Lisa J. Keogh, Solomon Tesfaye, Jonathan Valabhji, John R. Petrie, Ketan K. Dhatariya, Tom Yates, Melanie J. Davies, Kamlesh Khunti   +17 more
wiley   +1 more source