Results 121 to 130 of about 2,674,072 (303)

ATP Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-Cell KATP Channels*

Journal of Biological Chemistry, 2010
ATP-sensitive potassium (KATP) channels are regulated by a variety of cytosolic factors (adenine nucleotides, Mg2+, phospholipids, and pH). We previously reported that KATP channels are also regulated by endogenous membrane-bound SNARE protein syntaxin ...
Youhou Kang, Yi Zhang, T. Liang, Y. Leung, Betty Ng, Huanli Xie, Nathan Chang, J. Chan, S. Shyng, R. Tsushima, H. Gaisano   +10 more
semanticscholar   +1 more source

Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis. [PDF]

J Neuroinflammation, 2023
Cummings J, Wu YL, Dixon CE, Henchir J, Simard JM, Panigrahy A, Kochanek PM, Jha RM, Aneja RK.   +8 more
europepmc   +1 more source

Assessing anti oxidant, antidiabetic potential and GCMS profiling of ethanolic root bark extract of Zanthoxylum rhetsa (Roxb.) DC: Supported by in vitro, in vivo and in silico molecular modeling.

PLoS ONE
Zanthoxylum rhetsa (ZR) is used traditionally to manage a variety of ailments, including diabetes. Oxidative stress may accelerate the diabetic condition.
Apurba Kumar Barman, Sumaiya Mahadi, Md Arju Hossain, Rahima Begum, Rabindra Nath Acharyya, Marjana Alam, Md Habibur Rahman, Nripendra Nath Biswas, A S M Monjur Al Hossain   +8 more
doaj   +1 more source

Novel mutations in a patient with KBG syndrome and sulfonylurea unresponsive ABCC8- Maturity onset of the Diabetes in Young

Rare
The proband was a 17-year-old girl born out of non-consanguineous marriage and delivered by vaginal delivery at 32 weeks of gestation. Gross motor skills were slightly delayed. At the age of 13 years, she was diagnosed with diabetes mellitus.
Debaditya Das, Arijit Singha, Anish Kar, Subhasis Neogi, Piyas Gargari, Nitai P. Bhattacharyya, Indira Maisnam, Pranab Kumar Sahana   +7 more
doaj   +1 more source

The Effect of Canagliflozin Dose on Renal and Cardiovascular Outcomes in Type 2 Diabetes and High Cardiovascular Risk

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Pharmacokinetic data suggest a potential dose‐dependent effect of sodium–glucose co‐transporter‐2 (SGLT‐2) inhibitors on surrogate markers of efficacy, but the impact of SGLT‐2 inhibitor dose on renal and cardiovascular outcomes remains uncertain.
Elias John Elenjickal, Frédéric Baroz, Philippe Boileau, Michael A. Tsoukas, Abhinav Sharma, Thomas A. Mavrakanas   +5 more
wiley   +1 more source

Covalent organic framework based cytoprotective therapy after ischemic stroke

Redox Biology
Cytoprotection has emerged as an effective therapeutic strategy for mitigating brain injury following acute ischemic stroke (AIS). The sulfonylurea receptor 1-transient receptor potential M4 (SUR1-TRPM4) channel plays a pivotal role in brain edema and ...
Yuqin Peng, Qingfan Ren, Huanrong Ma, Chuman Lin, Mingjia Yu, Yongchuan Li, Jiancong Chen, Haihao Xu, Peng Zhao, Suyue Pan, Jia Tao, Kaibin Huang   +11 more
doaj   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

<i>Abcc8</i> (Sulfonylurea Receptor-1) Impact on Brain Atrophy after Traumatic Brain Injury Varies by Sex. [PDF]

J Neurotrauma, 2021
Tata S, Zusman BE, Kochanek PM, Gerzanich V, Kwon MS, Woo SK, Clark RSB, Janesko-Feldman K, Vagni VA, Simard JM, Jha RM.   +10 more
europepmc   +1 more source

[Sulfonylurea receptors and their interaction with glimepiride].

Likars'ka sprava, 2003
In the review, data are presented on glymepiride (amaril), a 3-d generation sulphanylamide. The drug interacts with receptors to sulphonylurea--SUR X, that are found only in B-cells of the pancreas, which fact has been shown to be associated with a higher secretion of insulin, an increased sensitivity of peripheral tissues to this hormone and with ...
N A, Zueva, N V, Sologub, A S, Efimov
openaire   +1 more source

Sulfonylurea receptors and ATP-sensitive K+ channels in clonal pancreatic alpha cells. Evidence for two high affinity sulfonylurea receptors

Journal of Biological Chemistry, 1993
We tested for the presence of sulfonylurea receptors in pancreatic alpha cells. Two high affinity sulfonylurea receptors were identified in clonal pancreatic alpha cells (alpha TC-6): a 140-kDa species observed previously in clonal pancreatic beta cells (HIT) and a second 150-kDa protein.
A S, Rajan, L, Aguilar-Bryan, D A, Nelson, C G, Nichols, S W, Wechsler, J, Lechago, J, Bryan   +6 more
openaire   +2 more sources