Results 41 to 50 of about 25,287 (258)

Stability of sulforaphane for topical formulation [PDF]

Drug Development and Industrial Pharmacy, 2013
Sulforaphane (SFN) is a natural compound that has been investigated as a chemopreventive agent. SFN has been shown to inhibit the activator-protein-1 (AP-1) transcription factor and may be effective for inhibition of ultraviolet (UV) induced skin carcinogenesis.
Stephen J, Franklin, Sally E, Dickinson, Kelly L, Karlage, G T, Bowden, Paul B, Myrdal   +4 more
openaire   +2 more sources

Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]

, 2016
Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P., Chen, Fen, Chen, Shi Y, Fu, Jian F, Shan, Yu J, Wang, An S, Yao, An J, Zhang, Hui Q, Zhang, Xiao H, Zhao, Jin S, Zhou, Zu Q   +10 more
core   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source

Quantitative determination of sulforaphane from broccoli extract tablets and its role in the protection of acute liver injury induced by ethanol

浙江大学学报. 农业与生命科学版, 2013
Sulforaphane (SFN) is an isothiocyanate (ITC) which exists as a precursor of glucosinolate (GS) in various cruciferous vegetables especially in broccoli. Sulforaphane has been regarded as a potential of anti-cancer agent derived from diet, mostly because
LI Baolong, TIAN Sicong, TAN Jie, LI Bing, CHEN Jingyu, SHAN Yujuan   +5 more
doaj   +1 more source

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

Exploring the anti‐inflammatory activity of sulforaphane

Immunology & Cell Biology, 2023
AbstractDysregulation of innate immune responses can result in chronic inflammatory conditions. Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but come with a trade‐off of cumulative and serious side effects. Therefore, alternative drug options with improved safety profiles are urgently needed.
Katie Treasure, James Harris, Gary Williamson   +2 more
openaire   +3 more sources

Sulforaphane - role in aging and neurodegeneration [PDF]

GeroScience, 2019
In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables.
Santín-Márquez R., Alarcón-Aguilar A., López-Diazguerrero N.E., Königsberg M., Chondrogianni, Niki   +4 more
openaire   +3 more sources

Sulforaphane improves cognitive function administered following traumatic brain injury. [PDF]

, 2009
Recent studies have shown that sulforaphane, a naturally occurring compound that is found in cruciferous vegetables, offers cellular protection in several models of brain injury.
Dash, Pramod K, Moore, Anthony N, Orsi, Sara A, Zhang, Min, Zhao, Jing   +4 more
core   +1 more source

Anticancer properties of sulforaphane: current insights at the molecular level

Frontiers in Oncology, 2023
Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature ...
Muhammad Asif Ali, Noohela Khan, Nabeeha Kaleem, Waqas Ahmad, Salem Hussain Alharethi, Bandar Alharbi, Hassan H. Alhassan, Maher M. Al-Enazi, Ahmad Faizal Abdull Razis, Ahmad Faizal Abdull Razis, Babagana Modu, Babagana Modu, Daniela Calina, Javad Sharifi-Rad   +13 more
doaj   +1 more source

Stimulation of Suicidal Erythrocyte Death by Sulforaphane [PDF]

Basic & Clinical Pharmacology & Toxicology, 2014
AbstractSulforaphane, an isothiocyanate from cruciferous vegetable, counteracts malignancy. The effect is at least in part due to the stimulation of suicidal death or apoptosis of tumour cells. Mechanisms invoked in sulforaphane‐induced apoptosis include mitochondrial depolarization and altered gene expression.
Alzoubi K., Calabrò S., FAGGIO, Caterina, Lang F.   +3 more
openaire   +4 more sources