Results 51 to 60 of about 14,451 (212)

Sulforaphane is anticonvulsant and improves mitochondrial function [PDF]

Journal of Neurochemistry, 2015
AbstractThe nuclear factor erythroid 2‐related factor 2 pathway (Nrf2) has been previously identified to protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator sulforaphane in various seizure models and hippocampal mitochondrial bioenergetics.
Carrasco Pozo, Catalina, Tan, Kah Ni, Borges, Karin   +2 more
openaire   +3 more sources

Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase. [PDF]

PLoS ONE, 2015
Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that potently inhibits neoplastic cellular processes and prevents a number of disease states ...
Jed W Fahey, W David Holtzclaw, Scott L Wehage, Kristina L Wade, Katherine K Stephenson, Paul Talalay   +5 more
doaj   +1 more source

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, EarlyView.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

Novel targets of sulforaphane in primary cardiomyocytes identified by proteomic analysis. [PDF]

PLoS ONE, 2013
Cardiovascular diseases represent the main cause of mortality in the industrialized world and the identification of effective preventive strategies is of fundamental importance.
Cristina Angeloni, Silvia Turroni, Laura Bianchi, Daniele Fabbri, Elisa Motori, Marco Malaguti, Emanuela Leoncini, Tullia Maraldi, Luca Bini, Patrizia Brigidi, Silvana Hrelia   +10 more
doaj   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Sulforaphane Target Protein Prediction: A Bioinformatics Analysis

Applied Sciences
Sulforaphane, a phytochemical found in cruciferous vegetables and various nutraceutical foods, plays a crucial role in promoting well-being and combating various diseases.
Francisco Alejandro Lagunas-Rangel
doaj   +1 more source

Therapeutic effects of sulforaphane in ulcerative colitis: effect on antioxidant activity, mitochondrial biogenesis and DNA polymerization

Redox Report, 2022
Objectives Ulcerative colitis (UC), an inflammatory bowel disease, affects mucosal lining of colon leading to inflammation and ulcers. Sulforaphane is a natural compound obtained from cruciferous vegetables.
Abdullah Alattar, Reem Alshaman, Mohammed M. H. Al-Gayyar   +2 more
doaj   +1 more source

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez, Camila Leiva‐Castro, Ana M. Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana T. Carmona, Soledad López‐Enríquez, Francisca Palomares   +6 more
wiley   +1 more source

BoMyrosinase plays an essential role in sulforaphane accumulation in response to selenite treatment in broccoli

Horticultural Plant Journal
Sulforaphane, a naturally specialized metabolite, plays significant roles in human disease prevention and plant defense. Myrosinase (MY) is a key gene responsible for the catalysis of sulforaphane formation, but the molecular mechanisms through which MY ...
Qiuyun Wu, Qi Wu, Yuxiao Tian, Chunyan Zhou, Shuxiang Mao, Junwei Wang, Ke Huang   +6 more
doaj   +1 more source

Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate

Journal of Pharmacological Sciences, 2011
Oxidative stress plays pivotal roles in aging, neurodegenerative disease, and pathological conditions such as ischemia. We investigated the effect of sulforaphane and 6-(methysulfinyl) hexyl isothiocyanate (6-HITC), a naturally occurring isothiocyanate ...
Keita Mizuno, Toshiaki Kume, Chie Muto, Yuki Takada-Takatori, Yasuhiko Izumi, Hachiro Sugimoto, Akinori Akaike   +6 more
doaj   +1 more source