Results 51 to 60 of about 25,287 (258)

Targeting crosstalk between Nrf-2, NF-κB and androgen receptor signaling in prostate cancer [PDF]

, 2018
Oxidative stress, inflammation and androgen receptor (AR) signaling play a pivotal role in the initiation, development and progression of prostate cancer (PCa).
Khurana, Namrata, Sikka, Suresh C
core   +2 more sources

Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma [PDF]

BMB Reports, 2012
Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane), belongingto a family of natural compounds that are abundant in broccoli,has received significant therapeutic interest in recent years.However, the molecular basis of its effects remains to ...
Jun Ho Park, Jong Won Kim, Chang-Min Lee, Yeong Dae Kim, Sung Woon Chung, In Duk Jung, Kyung Tae Noh, Jin Wook Park, Deok Rim Heo, Yong Kyoo Shin, Jong Keun Seo, Yeong-Min Park   +11 more
doaj   +1 more source

Bioavailability of Glucoraphanin and Sulforaphane From High-Glucoraphanin Broccoli [PDF]

, 2018
Scope: Broccoli accumulates 4-methylsulphinylbutyl glucosinolate (glucoraphanin) which is hydrolyzed to the isothiocyanate sulforaphane. Through the introgression of novel alleles of the Myb28 transcription factor from Brassica villosa, broccoli ...
Al Janobi, Aune, Clarke, Clarke, Cotton, Covault, Fuentes, Gasper, Gigolashvili, Juge, Kassahun, Liu, Liu, Luang-In, Mithen, Saha, Sonderby, Thomson, Traka, Tse, Vermeulen, Wu, Zhang   +22 more
core   +1 more source

Genetic regulation of glucoraphanin accumulation in Beneforté® broccoli [PDF]

, 2013
Diets rich in broccoli (Brassica oleracea var italica) have been associated with maintenance of cardiovascular health and reduction in risk of cancer. These health benefits have been attributed to glucoraphanin that specifically accumulates in broccoli ...
Anon, Frans den Bosch, Gene Mero, Guy C Barker, Hans Schepers, Howard Constant, Jonathan Moore, Leo Kelly, Maria H Traka, Peter G Walley, R Development Core Team., Richard F Mithen, Rozen S, Sekhar Boddupalli, Seow A, Shikha Saha, Stanislav Kopriva, Stine Huseby   +17 more
core   +1 more source

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner [PDF]

, 2021
BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of cellular homeostasis, among which are those regulated by the stress response ...
Ahn, Clarke, Cornblatt, Dibble, Dinkova-Kostova, Fang, Ferreira de Oliveira, Hawley, Iaconelli, Jeong, Kim, Kumar, Matsui, Matsui, Morales, Moreno-Gonzalo, Myzak, Nave, Nishioka, Rozengurt, Sawai, Saxton, Shawky, Shen, Torrente, Wiczk, Wu, Yang, Zhang, Zhang, Zhang, Zhang, Zhang   +32 more
core   +3 more sources

Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota

Frontiers in Physiology
Glucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Tetiana R. Dmytriv, Tetiana R. Dmytriv, Oleh Lushchak, Oleh Lushchak, Volodymyr I. Lushchak, Volodymyr I. Lushchak   +5 more
doaj   +1 more source

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane:Targeting the NRF2 Pathway with Sulforaphane [PDF]

, 2017
Background: Since the re-discovery of sulforaphane in 1992 and the recognition of the bioactivity of this phytochemical, many studies have examined its mode of action in cells, animals and humans.
Dinkova-Kostova, Albena T., Fahey, Jed W., Kensler, Thomas W., Kostov, Rumen V.   +3 more
core   +2 more sources

Microwave cooking increases sulforaphane level in broccoli [PDF]

Food Science & Nutrition, 2020
AbstractSulforaphane (SFR), an anticarcinogenic compound, forms from the hydrolysis of glucoraphanin (GLR) in broccoli. Cooking methods have been shown to affect broccoli GLR and SFR levels, but little is known about the effect of lightly cooking processes on them.
Yingjian Lu, Xinyi Pang, Tianbao Yang
openaire   +3 more sources

Sulforaphane attenuates EGFR signaling in NSCLC cells [PDF]

Journal of Biomedical Science, 2015
EGFR, a receptor tyrosine kinase (RTK), is frequently overexpressed and mutated in non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitors (TKIs) have been widely used in the treatment of many cancers, including NSCLC. However, intrinsic and acquired resistance to TKI remains a common obstacle.
Chen, Chi-Yuan, Yu, Zhu-Yun, Chuang, Yen-Shu, Huang, Rui-Mei, Wang, Tzu-Chien V   +4 more
openaire   +2 more sources

Alginate Oligosaccharides Attenuate Ochratoxin A‐Induced Liver Injury through Regulating the Interaction of Nrf2 and NF‐κB Signaling Pathways

Food Frontiers, EarlyView.
A schematic illustration for the protective effects of AOS on OTA‐induced liver injury in mice. AOS, alginate oligosaccharides; CAT, catalase; GSTT1, glutathione S‐transferase theta 1; HO‐1, heme oxygenase 1; IκBα, inhibitor kappa B alpha; IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; Keap1, kelch‐like ech‐associated protein 1; NF‐κB, nuclear factor ...
Yue Zhao, Xueqing Ye, Yan Guo, Zhongxiang Zhao, Qinghua Yao, Yaoyao Wang, Huimei Liu, Ziwei Lin, Wenchao Liu   +8 more
wiley   +1 more source