Results 71 to 80 of about 14,451 (212)

Research Progress of Ferroptosis in Cerebral Infarction

Brain and Behavior, Volume 16, Issue 1, January 2026.
Cerebral infarction triggers ischemia–reperfusion injury, leading to iron overload, oxidative stress, and mitochondrial dysfunction, which together initiate ferroptosis—an iron‐dependent, lipid peroxidation–driven form of neuronal death. Disruption of the System Xc−/GSH/GPX4 antioxidant axis and ACSL4‐mediated PUFA phospholipid enrichment accelerates ...
Yilan Fei, Qi Leng
wiley   +1 more source

Neuroprotective Effect of Sulforaphane against Methylglyoxal Cytotoxicity [PDF]

Chemical Research in Toxicology, 2015
Glycation, an endogenous process that leads to the production of advanced glycation end products (AGEs), plays a role in the etiopathogenesis of different neurodegenerative diseases, such as Alzheimer's disease (AD). Methylglyoxal is the most potent precursor of AGEs, and high levels of methylglyoxal have been found in the cerebrospinal fluid of AD ...
ANGELONI, CRISTINA, MALAGUTI, MARCO, RIZZO, BENEDETTA, BARBALACE, MARIA CRISTINA, Fabbri, Daniele, HRELIA, SILVANA   +5 more
openaire   +2 more sources

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source

Sulforaphane regulates AngII-induced podocyte oxidative stress injury through the Nrf2-Keap1/ho-1/ROS pathway

Renal Failure
Objective This study aimed to investigate the therapeutic effects of sulforaphane and the role of the Nrf2-Keap1/HO-1/ROS pathway in AngII-induced oxidative stress in podocyte injury.Methods Mouse mpc5 podocytes were divided into four groups: control ...
Wen Lu
doaj   +1 more source

Transcriptome reveals the gene expression patterns of sulforaphane metabolism in broccoli florets.

PLoS ONE, 2019
Sulforaphane is a new and effective anti-cancer component that is abundant in broccoli. In the past few years, the patterns of variability in glucosinolate content and its regulation in A. thaliana have been described in detail. However, the diversity of
Zhansheng Li, Yumei Liu, Lingyun Li, Zhiyuan Fang, Limei Yang, Mu Zhuang, Yangyong Zhang, Honghao Lv   +7 more
doaj   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Sulforaphane as a preventive agent in Oral Cancer- A Systematic Review

Oral Oncology Reports
Background: Cancer is one of the leading causes of death worldwide. Of these, oral cancer is the sixth most common malignancy. Several phytochemicals are emerging these days in prevention of oral cancer. Sulforaphane present in broccoli is one such agent
M. Parasakthi, Kavitha Sanjeev
doaj   +1 more source

Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway

Dose-Response, 2019
Sulforaphane exerts anti-inflammatory activity in inflammatory diseases. The endometriosis (EM) is accompanied by chronic inflammation. The present study aims to explore the therapeutic effects of sulforaphane on EM and its underlying mechanism.
Aixiu Zhou, Yiting Hong, Yuchun Lv
doaj   +1 more source

Elucidation of Sulforaphane‐Mediated Effects on the Cellular Human Metabolome Using Metabolic Profiling

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Sulforaphane (SFN) is an isothiocyanate derived from broccoli and is related to various health‐promoting effects. By using metabolic profiling on the hepatoblastoma cell line HepG2 several effects on pathways such as TCA cycle, urea cycle and redox metabolism through SFN were identified.
Nadine Bieß, Hans‐Ulrich Humpf, Matthias Behrens, Andrea Gerdemann   +3 more
wiley   +1 more source

Albiflorin‐Mediated MAP2K1 Targeting and HIF‐1 Signaling Inhibition Contribute to the Therapeutic Efficacy in Hyperuricemia‐Associated Cognitive Impairment

Human Mutation, Volume 2026, Issue 1, 2026.
This study investigated the therapeutic effects and mechanisms of Paeonia suffruticosa fruit pod extract (EMP) and its main component albiflorin (AF) on hyperuricemia‐associated cognitive impairment (HUA‐CI). A HUA‐CI mouse model was established, with cognitive function evaluated via Morris water maze.
Huimin Xiao, Xinwen Huang, Rui Yao, Jincai Liu, Linrui Duan, Siwang Wang, Jinming Gao, Minghua Ren   +7 more
wiley   +1 more source