Results 41 to 50 of about 4,952 (265)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecules, 2017 The sulfinylation reaction of aromatic and hetero-aromatic compounds with sulfinic esters as electrophiles has been investigated in different ionic liquids and by means of different Lewis acid salts in order to get moderate to good yields of asymmetrical
Ngoc-Lan Thi Nguyen +3 more
doaj +1 more source
Dearomative di- and trifunctionalization of aryl sulfoxides via [5,5]-rearrangement
Nature Communications, 2022 In contrast with well-established dearomatization protocols such as the Birch reduction, sigmatropic rearrangement-based dearomatizations are a less-explored but potentially effective route to saturated compounds.
Mengjie Hu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Benzyl 2,4-dichlorophenyl sulfoxide
MolbankBenzyl 2,4-dichlorophenyl sulfoxide was synthesized both in racemic and in an enantiopure form. This enantiopure sulfoxide is a further successful confirmation of our straightforward protocol to yield easily chiral aryl benzyl sulfoxides.
Maria Annunziata M. Capozzi +2 more
doaj +1 more source
Advancements in Asymmetric Synthesis of Esomeprazole and Chiral Sulfoxide Drugs: A Comprehensive Review and Future Perspectives [PDF]
E3S Web of ConferencesChiral sulfoxides are widely present in biologically active molecules and pharmaceuticals, and their efficient and green synthesis has been a hot research topic.
Yu Jingwen
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Nature Communications, 2022 Conformational isomerization of organic molecules can be guided by noncovalent interactions. Here, the authors report the synthesis of chiral sulfoxides catalyzed by N-heterocyclic carbenes; intramolecular chalcogen bonding interactions are key for ...
Jianjian Liu +4 more
doaj +1 more source
Sulfoxides. V. The Ionization of Sulfoxides in Sulfuric Acid [PDF]
Bulletin of the Chemical Society of Japan, 1965 Abstract Contrary to the earlier claim that diphenyl sulfoxide ionizes in nearly 100% sulfuric acid to give a “diphenyl sulfidonium” ion, which can then return to the original sulfoxide when quenched with water, the 18O tracer experiment and a new set of cryoscopic determinations of a few sulfoxides have revealed that the dissociation of
Shigeru Oae +2 more
openaire +1 more source