Results 51 to 60 of about 17,437 (312)

Investigation of the chemoselective and enantioselective oxidation of α-thio-β-chloroacrylamides [PDF]

, 2008
Investigation of the chemoselective and enantioselective oxidation of α-thio-β-chloroacrylamides is described. The α-thio-β-chloroacrylamides can be selectively oxidized to either the racemic sulfoxide or the sulfone very efficiently.
Chopra, Jay, Kissane, Marie, Lawrence, Simon E., Lynch, Denis, Maguire, Anita R.   +4 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Distribution of S-alk(en)yl-l-cysteine Sulfoxides in Garlic (Allium sativum L.)

Czech Journal of Food Sciences, 2009
This study was devoted to distribution of S-alk(en)yl-L-cysteine sulfoxides (particularly alliin, methiin, and isoalliin) in plants of Allium sativum L.
J. Horníčková, J. Velíšek, J. Ovesná, H. Stavělíková   +3 more
doaj   +1 more source

Aetiology and treatment of epidermal depigmentory disorder in humans [PDF]

, 2012
The epidermal depigmentary trigger in humans at post-natal level may occur with the toxification of skin organ with the endogenously produced melanocytotoxic hydrogen peroxide and subsequent formation of hydrogen peroxide- melanolipoprotein conjugate ...
S. S. Sawhney
core   +1 more source

Radical Mechanism in the Elimination of 2-Arylsulfinyl Esters [PDF]

, 2012
The mechanism of the dehydrosulfenylation of 2-arylsulfinyl esters was investigated. The reaction was found to follow a homolytic cleavage mechanism as verified by electrospray ionization tandem mass spectrometry and experimental work.
González, Florenci, Izquierdo Ferrer, Javier, Latorre, Antonio, López Martín, Irakusne, Ramírez, Victoria, Rodríguez Pastor, Santiago, Vicent Barrera, Cristian   +6 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Versatile C(sp2)−C(sp3) ligand couplings of sulfoxides for the enantioselective synthesis of diarylalkanes [PDF]

, 2016
The reaction of chiral (hetero)aryl benzyl sulfoxides with Grignard reagents affords enantiomerically pure diarylalkanes in up to 98% yield and greater than 99.5% enantiomeric excess.
Aggarwal, Andries, Bagutski, Burns, Burns, Capozzi, Carreño, Chausset-Boissarie, Costantino, Crudden, Delouvrié, Eberhart, Eberhart, Eberhart, Evans, Farid, Gianino, Glasspoole, Glasspoole, Han, Hartwig, Hoffmann, Kawai, Khim, Kita, Kopp, Lennox, Li, Liu, Lozada, Matthew, McAllister, McAllister, Melzig, Miller, Moragas, Moriarty, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Procopiou, Pummerer, Robak, Rochette, Roe, Roe, Roe, Roesner, Schmidt, Shang, Smith, Smith, Snyder, Solá, Sonawane, Stymiest, Ting, Tohma, Tolstoy, Trost, Trost, Wakabayashi, Watson, Wittig, Yoshida, Zhong, Çalimsiz   +72 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sulfoxides: potent co-crystal formers [PDF]

, 2013
The design of co-crystals requires knowledge of robust supramol. synthons. The sulfoxide is a potent H bond acceptor and was used as a co-crystal former with a range of NH functional groups, via N-H···O=S H bonds.
Eccles, Kevin S., Elcoate, Curtis J., Lawrence, Simon E., Maguire, Anita R., Stokes, Stephen P.   +4 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source