Results 51 to 60 of about 9,711 (311)

Dramatic Influence of Ionic Liquid and Ultrasound Irradiation on the Electrophilic Sulfinylation of Aromatic Compounds by Sulfinic Esters

Molecules, 2017
The sulfinylation reaction of aromatic and hetero-aromatic compounds with sulfinic esters as electrophiles has been investigated in different ionic liquids and by means of different Lewis acid salts in order to get moderate to good yields of asymmetrical
Ngoc-Lan Thi Nguyen, Hong-Thom Vo, Fritz Duus, Thi Xuan Thi Luu   +3 more
doaj   +1 more source

Dearomative di- and trifunctionalization of aryl sulfoxides via [5,5]-rearrangement

Nature Communications, 2022
In contrast with well-established dearomatization protocols such as the Birch reduction, sigmatropic rearrangement-based dearomatizations are a less-explored but potentially effective route to saturated compounds.
Mengjie Hu, Yanping Liu, Yuchen Liang, Taotao Dong, Lichun Kong, Ming Bao, Zhi-Xiang Wang, Bo Peng   +7 more
doaj   +1 more source

Chemoenzymatic synthesis of enantiopure hydroxy sulfoxides derived from substituted arenes

, 2016
Enantiopure β-hydroxy sulfoxides and catechol sulfoxides were obtained, by chemoenzymatic synthesis, involving dioxygenase-catalysed benzylic hydroxylation or arene cis-dihydroxylation and cis-diol dehydrogenase-catalysed dehydrogenation.
Ljubez, Vera, Sharma, Narain D., Murphy, Deirdre, Allen, Christopher C R, Boyd, Derek R., Malone, John F., Shepherd, Steven D.   +6 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Benzyl 2,4-dichlorophenyl sulfoxide

Molbank
Benzyl 2,4-dichlorophenyl sulfoxide was synthesized both in racemic and in an enantiopure form. This enantiopure sulfoxide is a further successful confirmation of our straightforward protocol to yield easily chiral aryl benzyl sulfoxides.
Maria Annunziata M. Capozzi, Joan F. Piniella Febrer, Cosimo Cardellicchio   +2 more
doaj   +1 more source

Advancements in Asymmetric Synthesis of Esomeprazole and Chiral Sulfoxide Drugs: A Comprehensive Review and Future Perspectives [PDF]

E3S Web of Conferences
Chiral sulfoxides are widely present in biologically active molecules and pharmaceuticals, and their efficient and green synthesis has been a hot research topic.
Yu Jingwen
doaj   +1 more source

Chalcogen bond-guided conformational isomerization enables catalytic dynamic kinetic resolution of sulfoxides

Nature Communications, 2022
Conformational isomerization of organic molecules can be guided by noncovalent interactions. Here, the authors report the synthesis of chiral sulfoxides catalyzed by N-heterocyclic carbenes; intramolecular chalcogen bonding interactions are key for ...
Jianjian Liu, Mali Zhou, Rui Deng, Pengcheng Zheng, Yonggui Robin Chi   +4 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Selective dehydrogenation of tetrahydroisoquinolines in the presence of sulfoxides

1,2,3,4-Tetrahydroisoquinolines undergo selective dehydrogenation in the presence of compounds with a highly polar X=O bond, particularly sulfoxides, under aerobic conditions to give the corresponding 3,4-dihydroisoquinolines. The reaction can be carried
Spagna, Francesca, Moody, Christopher J.
core   +1 more source