Results 61 to 70 of about 9,711 (311)
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Palladium-Catalyzed Direct Arylation of Methyl Sulfoxides with Aryl Halides
, 2016 The palladium-catalyzed α-arylation of unactivated sulfoxides has been developed. The weakly acidic α-protons of sulfoxides are reversibly deprotonated by LiOtBu, and a palladium phosphine complex facilitates the arylation.
Tiezheng Jia (1317159) +4 more
core +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Sulfoxides. V. The Ionization of Sulfoxides in Sulfuric Acid [PDF]
Bulletin of the Chemical Society of Japan, 1965 Abstract Contrary to the earlier claim that diphenyl sulfoxide ionizes in nearly 100% sulfuric acid to give a “diphenyl sulfidonium” ion, which can then return to the original sulfoxide when quenched with water, the 18O tracer experiment and a new set of cryoscopic determinations of a few sulfoxides have revealed that the dissociation of
Shigeru Oae +2 more
openaire +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Diastereoselective reduction of protein‐bound methionine sulfoxide by methionine sulfoxide reductase [PDF]
FEBS Letters, 1999 Methionine sulfoxide (MetSO) in calmodulin (CaM) was previously shown to be a substrate for bovine liver peptide methionine sulfoxide reductase (pMSR, EC 1.8.4.6), which can partially recover protein structure and function of oxidized CaM in vitro. Here, we report for the first time that pMSR selectively reduces the D‐sulfoxide diastereomer of CaM ...
Sharov, Victor S. +3 more
openaire +2 more sources
Synthesis Of Enantiomerically Pure (Z)-2-Haloalkenyl Sulfoxides
, 1992 Efficient procedures to prepare enantiomerically pure (Z)-2-haloalkenyl sulfoxides from alkynyl sulfoxides are ...
De La Pradilla, R. F. +2 more
core +1 more source
The conformation of alkyl sulfoxides [PDF]
, 1981 Parameters for sulfoxides used in force field MM1 were modified to be incorporated into force field MM2. The conformations of ten alkyl sulfoxides were then calculated using MM2 with these new parameters.
Tai, Julia C.
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Nickel-Catalyzed Oxidative Coupling Reaction of Phenyl Benzyl Sulfoxides
, 2018 A novel method to produce disulfoxides diastereoselectively from phenyl benzyl sulfoxides is reported. The Ni(PnBu3)2Cl2]/NIXANTPHOS catalyst system successfully promotes an oxidative coupling reaction of aryl benzylic sulfoxides to disulfoxides.
Patrick J. Walsh (304213) +3 more
core +2 more sources