Results 91 to 100 of about 50,255 (242)

Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1

Proceedings of the National Academy of Sciences, 1999
Posttranslational modifications such as ubiquitination and phosphorylation play an important role in the regulation of cellular protein function. Homeodomain-interacting protein kinase 2 (HIPK2) is a member of the recently identified family of nuclear protein kinases that act as corepressors for homeodomain transcription factors.
Y H, Kim, C Y, Choi, Y, Kim
openaire   +3 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

MORC3, a component of PML nuclear bodies, has a role in restricting herpes simplex virus type 1 and human cytomegalovirus [PDF]

, 2016
We previously reported that MORC3, a protein associated with promyelocytic leukemia nuclear bodies (PML NBs), is a target of HSV-1 ICP0 mediated degradation.
Everett, Roger, Orr, Anne, Sloan, Elizabeth   +2 more
core   +1 more source

Distinct and Overlapping Sets of SUMO-1 and SUMO-2 Target Proteins Revealed by Quantitative Proteomics

Molecular & Cellular Proteomics, 2006
The small ubiquitin-like modifier (SUMO) family in vertebrates includes three different family members that are conjugated as post-translational modifications to target proteins. SUMO-2 and -3 are nearly identical but differ substantially from SUMO-1.
Vertegaal, Alfred C.O., Andersen, Jens S., Ogg, Stephen C., Hay, Ronald T., Mann, Matthias, Lamond, Angus I.   +5 more
openaire   +5 more sources

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

The PML-nuclear inclusion of human supraoptic neurons: a new compartment with SUMO-1- and ubiquitin–proteasome-associated domains

Neurobiology of Disease, 2006
It is well known that the cell nucleus is organized in structural and functional compartments involved in transcription, RNA processing and protein modifications such as conjugation with SUMO-1 and proteolysis.
Nuria T. Villagra, Joaquin Navascues, Iñigo Casafont, J. Fernando Val-Bernal, Miguel Lafarga, Maria T. Berciano   +5 more
doaj   +1 more source

Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage. [PDF]

PLoS ONE, 2011
We have previously shown that a massive increase in global SUMOylation occurs during torpor in ground squirrels, and that overexpression of Ubc9 and/or SUMO-1 in cell lines and cortical neurons protects against oxygen and glucose deprivation.
Yang-Ja Lee, Yongshan Mou, Dragan Maric, Dace Klimanis, Sungyoung Auh, John M Hallenbeck   +5 more
doaj   +1 more source

Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins [PDF]

, 2008
Background: The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail.
Deshaies, Raymond J., Elsasser, Suzanne, Finley, Daniel, Goh, Amanda M., Howley, Peter M., Verma, Rati, Walters, Kylie J.   +6 more
core   +6 more sources

The Inhibitory Function in Human Progesterone Receptor N Termini Binds SUMO-1 Protein to Regulate Autoinhibition and Transrepression [PDF]

Journal of Biological Chemistry, 2002
Although most studies of progesterone receptors (PR) and their two isoforms, PR-A and PR-B, focus on transcriptional stimulation, the receptors exhibit important inhibitory properties. Autoinhibition refers to an inhibitory function located in the PR N terminus, whose deletion increases transcriptional activity at least 6-10-fold.
Hany, Abdel-Hafiz, Glenn S, Takimoto, Lin, Tung, Kathryn B, Horwitz   +3 more
openaire   +2 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source